The HTLV-I Tax oncoprotein targets the retinoblastoma protein for proteasomal degradation (Q40484581)

20 September 2017

title

The HTLV-I Tax oncoprotein targets the retinoblastoma protein for proteasomal degradation (English)

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Human T-lymphotropic virus 1

20 September 2017

main subject

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Renaud Mahieux

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Maria Elena Bottazzi

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20 September 2017

Fatah Kashanchi

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20 September 2017

Kylene Kehn

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20 September 2017

Cynthia de la Fuente

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20 September 2017

Katharine Strouss

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20 September 2017

Reem Berro

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20 September 2017

Hua Jiang

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20 September 2017

John Brady

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20 September 2017

Anne Pumfery

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20 September 2017

language of work or name

English

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publication date

1 January 2005

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20 September 2017

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20 September 2017

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20 September 2017

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20 September 2017

page(s)

525-540

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The proteasome: structure, function, and role in the cell

20 September 2017

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Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300

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The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

21 January 2018

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Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product

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Inhibition of retinoblastoma protein degradation by interaction with the serpin plasminogen activator inhibitor 2 via a novel consensus motif

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Overexpression of p21(waf1) in human T-cell lymphotropic virus type 1-infected cells and its association with cyclin A/cdk2.

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Paradoxical effects of a stress signal on pro- and anti-apoptotic machinery in HTLV-1 Tax expressing cells

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Protein Phosphatase 1 binds strongly to the retinoblastoma protein but not to p107 or p130 in vitro and in vivo

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Degradation of the retinoblastoma tumor suppressor by the human papillomavirus type 16 E7 oncoprotein is important for functional inactivation and is separable from proteasomal degradation of E7.

21 January 2018

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Transcriptional activation of RNA polymerase III-dependent genes by the human T-cell leukemia virus type 1 tax protein

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Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I.

21 January 2018

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Physical interaction of human T-cell leukemia virus type 1 Tax with cyclin-dependent kinase 4 stimulates the phosphorylation of retinoblastoma protein

21 January 2018

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Human T-cell leukemia virus-I tax oncoprotein functionally targets a subnuclear complex involved in cellular DNA damage-response

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Human T-cell leukemia virus type 1 Tax protein binds to assembled nuclear proteasomes and enhances their proteolytic activity

21 January 2018

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Pleiotropic effects of HTLV type 1 Tax protein on cellular metabolism: mitotic checkpoint abrogation and NF-kappaB activation

21 January 2018

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Molecular mechanism of cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I.

21 January 2018

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PCAF interacts with tax and stimulates tax transactivation in a histone acetyltransferase-independent manner

21 January 2018

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Role of E2F in cell cycle control and cancer

21 January 2018

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Destabilization of the RB tumor suppressor protein and stabilization of p53 contribute to HPV type 16 E7-induced apoptosis

21 January 2018

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Human cytomegalovirus pp71 stimulates cell cycle progression by inducing the proteasome-dependent degradation of the retinoblastoma family of tumor suppressors

21 January 2018

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Proteasome-dependent, ubiquitin-independent degradation of the Rb family of tumor suppressors by the human cytomegalovirus pp71 protein

21 January 2018

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The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells

21 January 2018

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Cyclin A is a functional target of retinoblastoma tumor suppressor protein-mediated cell cycle arrest

21 January 2018

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Cell-cycle-dependent changes in ceramide levels preceding retinoblastoma protein dephosphorylation in G2/M.

21 January 2018

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Clinical update: proteasome inhibitors in solid tumors

21 January 2018

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Direct binding of the N-terminus of HTLV-1 tax oncoprotein to cyclin-dependent kinase 4 is a dominant path to stimulate the kinase activity

21 January 2018

1 reference

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Human T-lymphotropic virus type 1 oncoprotein tax promotes unscheduled degradation of Pds1p/securin and Clb2p/cyclin B1 and causes chromosomal instability

21 January 2018

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Human T-cell leukemia virus type I and adult T-cell leukemia

21 January 2018

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Retinoblastoma protein partners

21 January 2018

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Direct coupling of the cell cycle and cell death machinery by E2F.

21 January 2018

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Expression and phosphorylation status of retinoblastoma protein in adult T-cell leukemia/lymphoma

21 January 2018

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Human T-cell leukemia virus type 1 Tax and cell cycle progression: role of cyclin D-cdk and p110Rb

21 January 2018

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The Rb/E2F pathway and cancer

21 January 2018

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Cell type-specific E2F activation and cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I.

21 January 2018

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The proteasome in cancer biology and treatment

21 January 2018

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Association between HTLV-1 Tax and I kappa B alpha is dependent on the I kappa B alpha phosphorylation state

21 January 2018

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21 January 2018

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Identification of a growth suppression domain within the retinoblastoma gene product

21 January 2018

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Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

21 January 2018

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Effects on NF-kappa B1/p105 processing of the interaction between the HTLV-1 transactivator Tax and the proteasome

21 January 2018

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Cellular transcription factors and regulation of IL-2 receptor gene expression by HTLV-I tax gene product.

21 January 2018

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The susceptibility to Fas-induced apoptosis in normal enterocytes is regulated on the level of cIAP1 and 2.

21 January 2018

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Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Regulation of RNA polymerase III transcription during cell cycle entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

HTLV-I Tax is a zinc-binding protein: role of zinc in Tax structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Human papillomavirus types 16 E6 and E7 contribute differently to carcinogenesis

21 January 2018

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Howard Temin memorial lectureship. Molecular biology of HTLV-1: deregulation of host cell gene expression and cell cycle

21 January 2018

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A single BIR domain of XIAP sufficient for inhibiting caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Human T cell leukemia virus type I (HTLV-I) and human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Both the PPPY and PTAP motifs are involved in human T-cell leukemia virus type 1 particle release

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Both Rb and E7 are regulated by the ubiquitin proteasome pathway in HPV-containing cervical tumor cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Mechanism of active transcriptional repression by the retinoblastoma protein

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Cellular targets for transformation by the adenovirus E1A proteins

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Protein profile of tax-associated complexes

21 January 2018

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Multiple viral strategies of HTLV-1 for dysregulation of cell growth control

21 January 2018

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What is the restriction point?

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

Transdominant human T-cell lymphotropic virus type I TAX1 mutant that fails to localize to the nucleus

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

7 January 2021

Extensive analysis of the retinoblastoma gene in adult T cell leukemia/lymphoma (ATL)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

7 January 2021

Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

7 January 2021

Human T-cell leukemia virus type 1 Tax releases cell cycle arrest induced by p16INK4a

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

7 January 2021

Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

7 January 2021

Stimulation of Cyclin-Dependent Kinase Activity and G1- to S-Phase Transition in Human Lymphocytes by the Human T-Cell Leukemia/Lymphotropic Virus Type 1 Tax Protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

7 January 2021

Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1208105

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1208105

1 reference

Dimensions Publication ID

20 September 2017

1049188802

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1 reference