Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis. (Q40453661)

20 September 2017

title

Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis. (English)

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20 September 2017

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Eileen J McMahon

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20 September 2017

Samantha L Bailey

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20 September 2017

Carol Vanderlugt Castenada

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20 September 2017

Hanspeter Waldner

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20 September 2017

Stephen D Miller

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20 September 2017

language of work or name

English

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publication date

27 February 2005

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20 September 2017

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20 September 2017

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20 September 2017

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20 September 2017

page(s)

335-339

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Epitope spreading in immune-mediated diseases: implications for immunotherapy

20 September 2017

cites work

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Spontaneous regression of primary autoreactivity during chronic progression of experimental autoimmune encephalomyelitis and multiple sclerosis

21 January 2018

1 reference

Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen

21 January 2018

1 reference

Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis

21 January 2018

1 reference

A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: a basis for peptide-specific therapy after onset of clinical disease

21 January 2018

1 reference

Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading

21 January 2018

1 reference

Temporal development of autoreactive Th1 responses and endogenous presentation of self myelin epitopes by central nervous system-resident APCs in Theiler's virus-infected mice

21 January 2018

1 reference

Myelin-specific tolerance attenuates the progression of a virus-induced demyelinating disease: implications for the treatment of MS.

21 January 2018

1 reference

Immune response in draining lymph nodes and Spleen After Intraventricular Injection of Antigen

21 January 2018

1 reference

In situ processing and distribution of intracerebrally injected OVA in the CNS.

21 January 2018

1 reference

Initiation of immune responses in brain is promoted by local dendritic cells

21 January 2018

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Transfer of central nervous system autoantigens and presentation in secondary lymphoid organs

21 January 2018

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Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo

21 January 2018

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Microglia are activated to become competent antigen presenting and effector cells in the inflammatory environment of the Theiler's virus model of multiple sclerosis

21 January 2018

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Intracerebral recruitment and maturation of dendritic cells in the onset and progression of experimental autoimmune encephalomyelitis

21 January 2018

1 reference

Brain dendritic cells and macrophages/microglia in central nervous system inflammation

21 January 2018

1 reference

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo.

21 January 2018

1 reference

Lymphatic efflux of intracerebrally injected cells

21 January 2018

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Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen

21 January 2018

1 reference

Trafficking of superparamagnetic iron oxide particles (Combidex) from brain to lymph nodes in the rat.

21 January 2018

1 reference

Two subsets of dendritic cells are present in human cerebrospinal fluid

21 January 2018

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CD83-positive dendritic cells are present in occasional perivascular cuffs in multiple sclerosis lesions.

21 January 2018

1 reference

Expression of CCR7 in multiple sclerosis: implications for CNS immunity

21 January 2018

1 reference

Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis.

21 January 2018

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Fulminant spontaneous autoimmunity of the central nervous system in mice transgenic for the myelin proteolipid protein-specific T cell receptor

21 January 2018

1 reference

De novo central nervous system processing of myelin antigen is required for the initiation of experimental autoimmune encephalomyelitis.

21 January 2018

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Naive T lymphocytes traffic to inflamed central nervous system, but require antigen recognition for activation

21 January 2018

1 reference

Pathologic role and temporal appearance of newly emerging autoepitopes in relapsing experimental autoimmune encephalomyelitis

21 January 2018

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Dendritic cells and differential usage of the MHC class II transactivator promoters in the central nervous system in experimental autoimmune encephalitis

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NM1202

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20 September 2017

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