Proliferation and Cdk4 expression in microsatellite unstable colon cancers with TGFBR2 mutations (Q40383884)

20 September 2017

title

Proliferation and Cdk4 expression in microsatellite unstable colon cancers with TGFBR2 mutations (English)

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20 September 2017

William M Grady

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20 September 2017

Joseph E Willis

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20 September 2017

Patty Trobridge

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20 September 2017

Judith Romero-Gallo

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20 September 2017

Nina Munoz

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20 September 2017

Joseph Olechnowicz

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20 September 2017

Kelly Ferguson

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20 September 2017

Shiva Gautam

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20 September 2017

Sanford D Markowitz

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20 September 2017

language of work or name

English

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publication date

1 February 2006

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International Journal of Cancer

20 September 2017

published in

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20 September 2017

volume

118

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20 September 2017

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20 September 2017

page(s)

600-608

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A benign cultured colon adenoma bears three genetically altered colon cancer oncogenes, but progresses to tumorigenicity and transforming growth factor-beta independence without inactivating the p53 tumor suppressor gene

20 September 2017

cites work

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Differential sensitivity of subclasses of human colon carcinoma cell lines to the growth inhibitory effects of transforming growth factor-beta 1.

21 January 2018

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Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

21 January 2018

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MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling

21 January 2018

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Mad-related genes in the human

21 January 2018

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Microsatellite instability in cancer of the proximal colon

21 January 2018

1 reference

Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers.

21 January 2018

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Demonstration That Mutation of the Type II Transforming Growth Factor β Receptor Inactivates Its Tumor Suppressor Activity in Replication Error-positive Colon Carcinoma Cells

21 January 2018

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Autocrine and exogenous transforming growth factor beta control cell cycle inhibition through pathways with different sensitivity.

21 January 2018

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Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer

21 January 2018

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Tumor suppressor activity of the TGF-beta pathway in human cancers

21 January 2018

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TGF-beta stimulation and inhibition of cell proliferation: new mechanistic insights

21 January 2018

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p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest

21 January 2018

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Truncation of the TGF-beta type II receptor gene results in insensitivity to TGF-beta in human gastric cancer cells

21 January 2018

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TGF-beta1 effects on proliferation of rat intestinal epithelial cells are due to inhibition of cyclin D1 expression

21 January 2018

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Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta

21 January 2018

1 reference

Transforming growth factor beta stabilizes p15INK4B protein, increases p15INK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cells

21 January 2018

1 reference

Transforming growth factor-beta and breast cancer: Cell cycle arrest by transforming growth factor-beta and its disruption in cancer

21 January 2018

1 reference

E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression

21 January 2018

1 reference

Transforming growth factor: signal transduction pathways, cell cycle mediation, and effects on hematopoiesis

21 January 2018

1 reference

Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15

21 January 2018

1 reference

To cycle or not to cycle: a critical decision in cancer.

21 January 2018

1 reference

The prognostic significance of p34cdc2 and cyclin D1 protein expression in prostate adenocarcinoma

21 January 2018

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The functional relationship between in vivo bromodeoxyuridine labeling index and Ki-67 proliferation index in human breast cancer

21 January 2018

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Down-regulation of p27 is associated with development of colorectal adenocarcinoma metastases

21 January 2018

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Aberrant expression of G1-phase cell cycle regulators in flat and exophytic adenomas of the human colon

21 January 2018

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Gastric cancers of the microsatellite mutator phenotype display characteristic genetic and clinical features

21 January 2018

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Correlative immunohistochemistry and molecular genetic study of the inactivation of the p16INK4A genes in astrocytomas

21 January 2018

1 reference

Increased expression of cyclin D1 is an early event in multistage colorectal carcinogenesis

21 January 2018

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Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

21 January 2018

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CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis

21 January 2018

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Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.

21 January 2018

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Colorectal carcinomas with high microsatellite instability: defining a distinct immunologic and molecular entity with respect to prognostic markers.

21 January 2018

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BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer

21 January 2018

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Mutations of BRAF are associated with extensive hMLH1 promoter methylation in sporadic colorectal carcinomas.

21 January 2018

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The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer

21 January 2018

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TGF beta inhibition of Cdk4 synthesis is linked to cell cycle arrest

21 January 2018

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Transforming growth factor beta enhances epithelial cell survival via Akt-dependent regulation of FKHRL1

21 January 2018

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PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

21 January 2018

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RAF/RAS oncogenes and mismatch-repair status

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IJC.21399

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release_ou7iw2i6hvhfjdxvegby23usea

20 September 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/ou7iw2i6hvhfjdxvegby23usea

mapped directly with Wikidata item

24 November 2022

based on heuristic

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