Short amyloid-beta (Abeta) immunogens reduce cerebral Abeta load and learning deficits in an Alzheimer's disease mouse model in the absence of an Abeta-specific cellular immune response. (Q40328434)

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scientific article published on May 2006

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English	Short amyloid-beta (Abeta) immunogens reduce cerebral Abeta load and learning deficits in an Alzheimer's disease mouse model in the absence of an Abeta-specific cellular immune response.	scientific article published on May 2006

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20 January 2020

Short amyloid-beta (Abeta) immunogens reduce cerebral Abeta load and learning deficits in an Alzheimer's disease mouse model in the absence of an Abeta-specific cellular immune response (English)

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20 January 2020

Alzheimer's disease

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3

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20 January 2020

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Marcel Maier

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20 January 2020

Timothy J Seabrook

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20 January 2020

Liying Jiang

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20 January 2020

Pritam Das

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20 January 2020

Christopher Janus

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20 January 2020

Cynthia A Lemere

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20 January 2020

language of work or name

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publication date

1 May 2006

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20 January 2020

Journal of Neuroscience

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20 January 2020

26

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20 January 2020

18

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20 January 2020

4717-4728

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20 January 2020

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunization against Alzheimer's beta -amyloid plaques via EFRH phage administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of amino acid spacers on the antigenicity of dimeric peptide--inducing cross-reacting antibodies to a cell surface protein antigen of Streptococcus mutans

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nasal A beta treatment induces anti-A beta antibody production and decreases cerebral amyloid burden in PD-APP mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of murine immunoglobulin G antibodies against human amyloid-beta1-42.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: implications for the pathogenesis and treatment of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebral hemorrhage after passive anti-Abeta immunotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intranasal immunotherapy for the treatment of Alzheimer's disease: Escherichia coli LT and LT(R192G) as mucosal adjuvants

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proinflammatory and vasoactive effects of Abeta in the cerebrovasculature

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Passage of amyloid beta protein antibody across the blood-brain barrier in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A$beta;1-15 is less immunogenic than A$beta;1-40/42 for intranasal immunization of wild-type mice but may be effective for ?boosting?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RGD motif enhances immunogenicity and adjuvanicity of peptide antigens following intranasal immunization

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Search strategies used by APP transgenic mice during navigation in the Morris water maze

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An attenuated immune response is sufficient to enhance cognition in an Alzheimer's disease mouse model immunized with amyloid-beta derivatives.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Species-specific immune response to immunization with human versus rodent A beta peptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Strategies for disease modification in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deciphering the molecular basis of memory failure in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lifelong immunization with human beta-amyloid (1-42) protects Alzheimer's transgenic mice against cognitive impairment throughout aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prototype Alzheimer's disease vaccine using the immunodominant B cell epitope from beta-amyloid and promiscuous T cell epitope pan HLA DR-binding peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment with an amyloid-beta antibody ameliorates plaque load, learning deficits, and hippocampal long-term potentiation in a mouse model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of the humoral and cellular immune response in Abeta immunotherapy by the adjuvants monophosphoryl lipid A (MPL), cholera toxin B subunit (CTB) and E. coli enterotoxin LT(R192G).

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta42 immunization in Alzheimer's disease generates Abeta N-terminal antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Risk factors associated with beta-amyloid(1-42) immunotherapy in preimmunization gene expression patterns of blood cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Laminin Receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developing novel immunogens for an effective, safe Alzheimer's disease vaccine

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthetic peptides containing T and B cell epitopes from human immunodeficiency virus envelope gp120 induce anti-HIV proliferative responses and high titers of neutralizing antibodies in rhesus monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein secondary structure and circular dichroism: a practical guide

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Helper T-cell antigenic site identification in the acquired immunodeficiency syndrome virus gp120 envelope protein and induction of immunity in mice to the native protein using a 16-residue synthetic peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fibronectin and its receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Place navigation impaired in rats with hippocampal lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conversion of an immunogenic human immunodeficiency virus (HIV) envelope synthetic peptide to a tolerogen in chimpanzees by the fusogenic domain of HIV gp41 envelope protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dissociation of Escherichia coli heat-labile enterotoxin adjuvanticity from ADP-ribosyltransferase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RGD and other recognition sequences for integrins

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced immunogenicity of HIV-1 vaccine construct by modification of the native peptide sequence

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial response to amyloid plaques in APPsw transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16672644

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.0381-06.2006

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16672644%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

PMC publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16672644%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16672644%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

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