Mammalian target of rapamycin is activated in human gastric cancer and serves as a target for therapy in an experimental model (Q40182123)

18 September 2017

title

Mammalian target of rapamycin is activated in human gastric cancer and serves as a target for therapy in an experimental model (English)

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18 September 2017

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Edward K Geissler

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18 September 2017

Sven A Lang

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18 September 2017

Andreas Gaumann

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18 September 2017

Gudrun E Koehl

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18 September 2017

Ulrike Seidel

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18 September 2017

Frauke Bataille

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18 September 2017

Dagmar Klein

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18 September 2017

Lee M Ellis

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18 September 2017

Ulrich Bolder

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18 September 2017

Ferdinand Hofstaedter

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18 September 2017

Hans-Jürgen Schlitt

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18 September 2017

Oliver Stoeltzing

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18 September 2017

language of work or name

English

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publication date

1 April 2007

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International Journal of Cancer

18 September 2017

published in

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18 September 2017

volume

120

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18 September 2017

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18 September 2017

page(s)

1803-1810

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Optimal locoregional treatment in gastric cancer

18 September 2017

cites work

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Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer

21 January 2018

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Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer

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Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer

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Role of hypoxia-inducible factor 1alpha in gastric cancer cell growth, angiogenesis, and vessel maturation

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BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin.

21 January 2018

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Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway

21 January 2018

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Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model

21 January 2018

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Akt phosphorylation associates with LOH of PTEN and leads to chemoresistance for gastric cancer

21 January 2018

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The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

21 January 2018

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Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

21 January 2018

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Rapamycin-induced endothelial cell death and tumor vessel thrombosis potentiate cytotoxic therapy against pancreatic cancer

21 January 2018

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Effect of rapamycin alone and in combination with antiangiogenesis therapy in an orthotopic model of human pancreatic cancer

21 January 2018

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Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer

21 January 2018

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Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin.

21 January 2018

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Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma

21 January 2018

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Induction of neuropilin-1 and vascular endothelial growth factor by epidermal growth factor in human gastric cancer cells

21 January 2018

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mTOR and P70 S6 kinase expression in primary liver neoplasms

21 January 2018

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Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers

21 January 2018

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Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer

21 January 2018

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Insulinlike growth factor-I-mediated migration and invasion of human colon carcinoma cells requires activation of c-Met and urokinase plasminogen activator receptor

21 January 2018

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Multistep tumorigenesis and the microenvironment

21 January 2018

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Antitumor activity of rapamycin in a transgenic mouse model of ErbB2-dependent human breast cancer

21 January 2018

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PI3K/Akt/mTOR pathway as a target for cancer therapy

21 January 2018

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Degradation of PKB/Akt protein by inhibition of the VEGF receptor/mTOR pathway in endothelial cells

21 January 2018

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The role of pericytes in blood-vessel formation and maintenance

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IJC.22442

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18 September 2017

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