Ras transformation mediates reovirus oncolysis by enhancing virus uncoating, particle infectivity, and apoptosis-dependent release (Q40141506)

17 September 2017

title

Ras transformation mediates reovirus oncolysis by enhancing virus uncoating, particle infectivity, and apoptosis-dependent release (English)

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17 September 2017

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Paola Marcato

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17 September 2017

Maya Shmulevitz

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17 September 2017

Da Pan

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17 September 2017

Don Stoltz

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17 September 2017

Patrick Wk Lee

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17 September 2017

language of work or name

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24 April 2007

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17 September 2017

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17 September 2017

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17 September 2017

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17 September 2017

page(s)

1522-1530

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Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity

17 September 2017

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Defective translational control facilitates vesicular stomatitis virus oncolysis

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Negative regulation of the alpha interferon-induced antiviral response by the Ras/Raf/MEK pathway

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The preferential cytotoxicity of reovirus for certain transformed cell lines

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The molecular basis of viral oncolysis: usurpation of the Ras signaling pathway by reovirus

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Species- and cell type-specific requirements for cellular transformation

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Reovirus: evidence for a second step in the intracellular uncoating and transcriptase activation process

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Putative autocleavage of reovirus mu1 protein in concert with outer-capsid disassembly and activation for membrane permeabilization

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Enhanced cathepsin L expression is mediated by different Ras effector pathways in fibroblasts and epithelial cells

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7 January 2021

Addition of exogenous protease facilitates reovirus infection in many restrictive cells

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Nonstructural proteins involved in genome packaging and replication of rotaviruses and other members of the Reoviridae

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Protein sigma 1 is the reovirus cell attachment protein

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Reovirus therapy of tumors with activated Ras pathway

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Unshackling the links between reovirus oncolysis, Ras signaling, translational control and cancer

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Increased expression of cathepsins L and B and decreased activity of their inhibitors in metastatic, ras-transformed NIH 3T3 cells

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Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells

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Infectious entry pathway for canine parvovirus

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Stepwise dismantling of adenovirus 2 during entry into cells

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Intermediates in influenza induced membrane fusion.

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KRAS(D13) Promotes apoptosis of human colorectal tumor cells by ReovirusT3D and oxaliplatin but not by tumor necrosis factor-related apoptosis-inducing ligand

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7 January 2021

Sensitization to apoptosis underlies KrasD12-dependent oncolysis of murine C26 colorectal carcinoma cells by reovirus T3D.

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7 January 2021

JNK regulates the release of proapoptotic mitochondrial factors in reovirus-infected cells.

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7 January 2021

Reovirus-induced apoptosis requires activation of transcription factor NF-kappaB.

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7 January 2021

Raf-independent deregulation of p38 and JNK mitogen-activated protein kinases are critical for Ras transformation

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7 January 2021

Oncogenic Ha-Ras-induced Signaling Activates NF-κB Transcriptional Activity, Which Is Required for Cellular Transformation

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7 January 2021

Endogenous inhibitors of the dsRNA-dependent eIF-2 alpha protein kinase PKR in normal and ras-transformed cells

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7 January 2021

Involvement of Double-stranded RNA-activated Protein Kinase in the Synergistic Activation of Nuclear Factor-κB by Tumor Necrosis Factor-α and γ-Interferon in Preneuronal Cells

1 reference

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7 January 2021

NF-kappaB activation by double-stranded-RNA-activated protein kinase (PKR) is mediated through NF-kappaB-inducing kinase and IkappaB kinase

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7 January 2021

Reovirus oncolysis: the Ras/RalGEF/p38 pathway dictates host cell permissiveness to reovirus infection

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7 January 2021

Polypeptide components of virions, top component and cores of reovirus type 3

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7 January 2021

Identifiers

DOI

10.1038/SJ.MT.6300179

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17 September 2017

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