Diphosphonates: History and mechanisms of action (Q40133991)

17 September 2017

1 reference

title

Diphosphonates: history and mechanisms of action (English)

1 reference

17 September 2017

Diphosphonates: History and mechanisms of action (English)

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

21 September 2023

H. Fleisch

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6300612

21 September 2023

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=6300612

21 September 2023

publication date

1 January 1981

1 reference

full work available at URL

17 September 2017

https://api.elsevier.com/content/article/PII:0221874781900448?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

https://api.elsevier.com/content/article/PII:0221874781900448?httpAccept=text/plain

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Metabolic bone disease & related research

21 September 2023

published in

1 reference

17 September 2017

1 reference

17 September 2017

issue

4-5

1 reference

17 September 2017

page(s)

279-287

1 reference

Fate and toxicity of orally administered polyethylene polyphosphonates

17 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Inhibition of vitamin D metabolism by ethane-1-hydroxyl-1, 1-diphosphonate.

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Effect of ethane-1-hydroxy-1,1-diphosphonate and vitamin D on bone mineralization

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

APD in Paget's disease of bone. Role of the mononuclear phagocyte system?

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Disaggregation of hydroxyapatite crystals

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The comparative effects of vitamin d deficiency and ethane-1-hydroxy-1,1-diphosphonate administration on the histology and glycolysis of chick epiphyseal and articular cartilage

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Influence of a Diphosphonate on Serum Calcium Homeostasis

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Reversal of the EHDP inhibition of calcium absorption by 1,25-dihydroxycholecalciferol

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Action of 1,25-dihydroxyvitamin D3 and a diphosphonate on calcium metabolism in rats

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Parathyroid hormone and renal handling of Pi: effect of dietary Pi and diphosphonates

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Inhibition of diphosphonate-blocked bone mineralization. Evidence that calcitonin promotes mineralization

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Evidence for the Promotion of Bone Mineralization by 1α,25-Dihydroxycholecalciferol in the Rat Unrelated to the Correction of Deficiencies in Serum Calcium and Phosphorus

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Effect of diphosphonates on hydroxyapatite formation induced by calcium-phospholipid-phosphate complexes

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The effects of phosphonates on experimental osteoporosis

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The effect of polyphloretin phosphate, polyoestradiol phosphate, a diphosphonate and a polyphosphate on calcification induced by dihydrotachysterol in skin, aorta and kidney of rats

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The cellular basis of bone resorption

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Influence of pyrophosphate and diphosphonates on rat liver adenylate cyclase

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Pyrophosphate analogues as inhibitors of herpes simplex virus type 1 DNA polymerase

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Effects of pyrophosphate and diphosphonates on the dissolution of hydroxyapatites using a flow system

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The effects of diphosphonates on the growth and glycolysis of connective-tissue cells in culture

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The effect of several diphosphonates on acid phosphohydrolases and other lysosomal enzymes

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Aggregation of calcium oxalate crystals: Effect of urine and various inhibitors

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Increase in alkaline phosphatase activity in calvaria cells cultured with diphosphonates

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Effect of diphosphonates on glycogen content of rabbit ear cartilage cells in culture

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Increase in fatty acid oxidation in calvaria cells cultured with diphosphonates

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Effect of diphosphonates on the synthesis of prostaglandins in cultured calvaria cells

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Mechanisms of calcification: role of collagen, polyphosphates, and phosphatase

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Isolation from urine of pyrophosphate, a calcification inhibitor

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Mechanism of calcification: inhibitory role of pyrophosphate

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Role of nucleation and inhibition in calcification

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The inhibitory effect of pyrophosphate on calcium oxalate precipitation and its relation to urolithiasis.

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

EFFECT OF ORTHOPHOSPHATE ON URINARY PYROPHOSPHATE EXCRETION AND THE PREVENTION OF UROLITHIASIS

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Inhibition of aortic calcification by means of pyrophosphate and polyphosphates

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Effect of condensed phosphates on calcification of chick embryo femurs in tissue culture

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Effect of pyrophosphate on hydroxyapatite and its implications in calcium homeostasis

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The inhibitory effect of phosphonates on the formation of calcium phosphate crystals in vitro and on aortic and kidney calcification in vivo.

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Comparative antiinflammatory and bone protective effects of two diphosphonates in adjuvant arthritis

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The inhibition of calcium hydroxypatite crystal growth by polyphosphonates and polyphosphates

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Diphosphonates inhibit formation of calcium phosphate crystals in vitro and pathological calcification in vivo.

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The effects of disodium ethane-1-hydroxy-1, 1-diphosphonate on adjuvant induced arthritis in rats

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The influence of disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) on the development of experimentally induced urinary stones in rats

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Effect of phosphates upon experimental skin calcinosis

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The effect of prostaglandin synthesis inhibitors and diphosphonates on tumour-mediated osteolysis

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The influence of two diphosphonates on calcium metabolism in the rat

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Molecular Biology of Mineralized Tissues with Particular Reference to Bone

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Diminished urinary excretion of cycle AMP by rats given disodium ethane-1-hydroxy-1,1-diphosphonate

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Comparison of effects of parathyroidectomy and ethane-1-hydroxy-1,1-diphosphonate (EHDP) administration upon bone synthesis of hydroxyproline and urinary excretion of hydroxyproline in rats

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The effect of two diphosphonates on the handling of calcium by rat kidney mitochondria in vitro.

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The effect of in vivo treatment with EHDP and/or 1,25-DHCC on calcium uptake and release in isolated kidney mitochondria.

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Effects of 1-hydroxyethane-1,1-diphosphonate and dichloromethanediphosphonate on rabbit articular chondrocytes in culture

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The effects of 1-hydroxyethane-1,1-diphosphonate and dichloromethanediphosphonate on collagen synthesis by rabbit articular chondrocytes and rat bone cells

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The influence of 1-hydroxyethane-1,1-diphosphonate and dichloromethanediphosphonate on lysine hydroxylation and cross-link formation in rat bone, cartilage and skin collagen

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Aggregation of hydroxyapatite crystals

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The concentration of inorganic pyrophosphate in human saliva and dental calculus

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Lipopolysaccharide-diphosphonate interaction on bone in tissue culture

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Indirect inhibition of the biosynthesis of 1,25-dihydroxycholecalciferol in rats treated with a diphosphonate

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Comparative effects of cetaben (PHB) and dichlormethylene diphosphonate (Cl2MDP) on the development of atherosclerosis in the cynomolgus monkey

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Effects of anticalcifying and antifibrobrotic drugs on pre-established atherosclerosis in the rabbit

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Role of proteoglycans in calcification of cartilage

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The binding of pyrophosphate and two diphosphonates by hydroxyapatite crystals

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Effect of sodium etidronate in adult cats

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Influence of diphosphonates on progress of experimentally induced osteoporosis

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Effect of Disodium Ethane-l-Hydroxy-1, 1 - Diphosphonate on Bone Formation

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The effect of agents interfering with soft tissue calcification and cell proliferation on calcific fibrous-fatty plaques in rabbits

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The short-term effects of high doses of ethylene-1-hydroxy-1, 1-diphosphonate upon early dentin formation

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The metabolic heterogeneity of glycosaminoglycans of the different zones of the epiphyseal growth plate and the effect of ethane-1-hydroxy-1, 1-diphosphonate (EHDP) upon glycosaminoglycan synthesis in vivo

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

In vitro distribution of 14C-labeled ethylene-1-hydroxy-1,1-diphosphonate in normal and treated young rats. An autoradiographic and ultrastructural study

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

A New Diphosphonate: Dissociation Between Effects on Cells and Mineral in Rats and a Preliminary Trial in Paget’s Disease

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Comparison of the effects of ethane-1-hydroxy-1,1-diphosphonate and dichloromethylene diphosphonate upon periodontal bone resorption in rice rats (Oryzomys palustris)

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The influence of multidentate organic phosphonates on the crystal growth of hydroxyapatite

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The inhibition of calcium oxalate crystal growth by multidentate organic phosphonates

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Effectiveness of Diphosphonates in Preventing ???Osteoporosis??? of Disuse in the Rat

21 September 2023

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Metabolism of disodium ethane-1-hydroxy-1,1-diphosphonate (disodium etidronate) in the rat, rabbit, dog and monkey

21 September 2023

100

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Ethane-1-hydroxy-1, 1-diphosphonate (EHDP). Effects on growth and modeling of the rat tibia

21 September 2023

101

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Ethane-1-hydroxy-1,1-diphosphonate (EHDP) effects on incorporation and accumulation of osteoclast nuclei

21 September 2023

102

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The effect of dichloromethylene diphosphonate, a pyrophosphate analog, on bone and bone cell structure in the growing rat

21 September 2023

103

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Boen remodelingin vitro: The effects of two diphosphonates on osteoid synthesis and bone resorption in mouse calvaria

21 September 2023

104

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Influence of dichloromethylene diphosphonate (Cl2MDP) and calcitonin on bone resorption, lactate production and phosphatase and pyrophosphatase content of mouse calvaria treated with parathyroid hormone in vitro

21 September 2023

105

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Effects of a diphophonate on calcium metabolism in calcium-deprived rats

21 September 2023

106

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The effects of diphosphonates, polyphosphates, and calcitonin on "immobilisation osteoporosis" in rats

21 September 2023

107

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Effect of diphosphonate on human supragingival calculus

21 September 2023

108

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Effects of pyrophosphate and diphosphonates on parathyroid hormone- and fluoride-stimulated adenylate cyclase activity

21 September 2023

110

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Influence of a diphosphonate on the cellular aspect of young bone tissue

21 September 2023

111

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The inhibitory effect of new diphosphonic acids on aortic and kidney calcification in vivo

21 September 2023

112

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Intestinal absorption of disodium ethane-1-hydroxy-1,1-diphosphonate (disodium etidronate) using a deconvolution technique.

21 September 2023

115

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Kinetic studies of bone and mineral metabolism during treatment with (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate (APD) in rats

21 September 2023

117

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The effect of two diphosphonates on the resorption of mouse calvaria in vitro

21 September 2023

118

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Inhibition by diphosphonates of bone resorption in mice and comparison with grey-lethal osteopetrosis

21 September 2023

119

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The effects of diphosphonates on the exchangeable and non-exchangeable calcium and phosphate of hydroxyapatite

21 September 2023

120

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Inhibitors of the growth and aggregation of calcium oxalate crystals in vitro

21 September 2023

121

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The effects of disodium ethane-1-hydroxy-1, 1-diphosphonate (EHDP)on bone and serum chemistry in rabbits

21 September 2023

122

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The effect of disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) on a rabbit model of athero-arteriosclerosis

21 September 2023

123

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The effects of various diphosphonates on a rat model of cardiac calciphylaxis

21 September 2023

124

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Resorption of bone implants. The effect of in vivo incorporation of a diphosphonate and fluoride on resorption

21 September 2023

125

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The alteration of osteoclast morphology by diphosphonates in bone organ culture

21 September 2023

126

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

URINARY PYROPHOSPHATE AND UROLITHIASIS

21 September 2023

127

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

EXCRETION OF INORGANIC PYROPHOSPHATE IN HYPOPHOSPHATASIA.

21 September 2023

128

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Inorganic pyrophosphate in plasma, urine, and synovial fluid of patients with pyrophosphate arthropathy (chondrocalcinosis or pseudogout).

21 September 2023

129

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

The influence of pyrophosphate, condensed phosphates, phosphonates and other phosphate compounds on the dissolution of hydroxyapatite in vitro and on bone resorption induced by parathyroid hormone in tissue culture and in thyroparathyroidectomised r

21 September 2023

130

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Inorganic pyrophosphate in plasma in normal persons and in patients with hypophosphatasia, osteogenesis imperfecta, and other disorders of bone

21 September 2023

131

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Effect of diphosphonates and calcitonin on the chemistry and quantitative histology of rat bone

21 September 2023

132

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Experimental renal osteodystrophy. The response to 25-hydroxycholecalciferol and dicholomethylene diphosphate therapy

21 September 2023

133

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Inhibition of skin calcification (calciphylaxis) by polyphosphates

21 September 2023

134

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Effect of ethane-1-hydroxy-1,1-diphosphonate (EHDP) and dichloromethylene diphosphonate (Cl 2 MDP) on the calcification and resorption of cartilage and bone in the tibial epiphysis and metaphysis of rats

21 September 2023

136

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Relation between bone mineralization, Ca absorption, and plasma Ca in phosphonate-treated rats

21 September 2023

138

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Regulation of the metabolism of 25-hydroxyvitamin D3 in primary cultures of chick kidney cells

21 September 2023

139

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Renal secretion of diphosphonates in rats

21 September 2023

141

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Ileal absorption of disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) and disodium dichloromethylene diphosphonate(C12 MDP) in the chick

21 September 2023

143

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

Effect of dichloromethylene diphosphonate on morphology, enzyme activity, and ash content of bones of thyroparathyroidectomized rats

21 September 2023

144

1 reference

https://api.crossref.org/works/10.1016/0221-8747(81)90044-8

21 September 2023

Identifiers

1 reference

17 September 2017

1 reference