Suppression of human colon cancer tumors in nude mice by siRNA CD44 gene therapy (Q40065941)

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English	Suppression of human colon cancer tumors in nude mice by siRNA CD44 gene therapy	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

17 September 2017

Suppression of human colon cancer tumors in nude mice by siRNA CD44 gene therapy (English)

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Europe PubMed Central

PubMed publication ID

17 September 2017

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author name string

Venkateswaran Subramaniam

1

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Europe PubMed Central

PubMed publication ID

17 September 2017

Isabella Regina Vincent

2

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Europe PubMed Central

PubMed publication ID

17 September 2017

Maliheh Gilakjan

3

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17 September 2017

Serge Jothy

4

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17 September 2017

publication date

7 September 2007

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17 September 2017

Experimental and Molecular Pathology

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17 September 2017

83

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Europe PubMed Central

PubMed publication ID

17 September 2017

3

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Europe PubMed Central

PubMed publication ID

17 September 2017

332-340

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Europe PubMed Central

PubMed publication ID

17 September 2017

CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion

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Effect of cationic carriers on the pharmacokinetics and tumor localization of nucleic acids after intravenous administration

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siRNA-based approaches in cancer therapy

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CD44 potentiates the adherence of metastatic prostate and breast cancer cells to bone marrow endothelial cells

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

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Disruption of epithelial cell-matrix interactions induces apoptosis

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Hyaluronan constitutively regulates ErbB2 phosphorylation and signaling complex formation in carcinoma cells.

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RNA interference-mediated gene silencing of pleiotrophin through polyethylenimine-complexed small interfering RNAs in vivo exerts antitumoral effects in glioblastoma xenografts

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A small interfering RNA targeting vascular endothelial growth factor inhibits Ewing's sarcoma growth in a xenograft mouse model

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A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells

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Post-transcriptional gene silencing by double-stranded RNA

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Introduction of antisense CD44S CDNA down-regulates expression of overall CD44 isoforms and inhibits tumor growth and metastasis in highly metastatic colon carcinoma cells

1 reference

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Potent siRNA inhibitors of ribonucleotide reductase subunit RRM2 reduce cell proliferation in vitro and in vivo

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Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA.

1 reference

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Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma

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Short interfering RNAs as a tool for cancer gene therapy

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Eradication of osteosarcoma lung metastases following intranasal interleukin-12 gene therapy using a nonviral polyethylenimine vector

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Targeting of CD44 eradicates human acute myeloid leukemic stem cells

1 reference

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RNA interference and potential therapeutic applications of short interfering RNAs

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Antiangiogenic gene therapy with systemically administered sFlt-1 plasmid DNA in engineered gelatin-based nanovectors

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Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells

1 reference

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CD44 negatively regulates apoptosis in murine colonic epithelium via the mitochondrial pathway

1 reference

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CD44 promotes resistance to apoptosis in human colon cancer cells

1 reference

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CD44 promotes resistance to apoptosis in murine colonic epithelium.

1 reference

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Small interfering RNA targeting Raf-1 inhibits tumor growth in vitro and in vivo

1 reference

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In vivo imaging of siRNA delivery and silencing in tumors

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A novel antiapoptotic mechanism based on interference of Fas signaling by CD44 variant isoforms

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CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain.

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Prostate cancer invasion is influenced more by expression of a CD44 isoform including variant 9 than by Muc18.

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PEI-alginate nanocomposites as efficient in vitro gene transfection agents

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CD44: from adhesion molecules to signalling regulators

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Emerging roles of caspase-3 in apoptosis

1 reference

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Short interfering RNA (siRNA) targeting the Lyn kinase induces apoptosis in primary, and drug-resistant, BCR-ABL1(+) leukemia cells

1 reference

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RANTES (CCL5) uses the proteoglycan CD44 as an auxiliary receptor to mediate cellular activation signals and HIV-1 enhancement

1 reference

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Changes in CD44 Expression during Carcinogenesis of the Mouse Colon

1 reference

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Butyrate mediates Caco-2 cell apoptosis via up-regulation of pro-apoptotic BAK and inducing caspase-3 mediated cleavage of poly-(ADP-ribose) polymerase (PARP).

1 reference

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Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons

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Molecular definition of breast tumor heterogeneity

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Altered growth of human colon cancer cell lines disrupted at activated Ki-ras

1 reference

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Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors

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Generation of artificial proteoglycans containing glycosaminoglycan-modified CD44. Demonstration of the interaction between rantes and chondroitin sulfate

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Motility of colon cancer cells: modulation by CD44 isoform expression

1 reference

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CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling

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RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

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Identifiers

10.1016/J.YEXMP.2007.08.013

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

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