Validation of the p21-activated kinases as targets for inhibition in neurofibromatosis type 2. (Q40040209)

16 September 2017

Validation of the p21-activated kinases as targets for inhibition in neurofibromatosis type 2. (English)

1 reference

16 September 2017

Anat Stemmer-Rachamimov

object named as

Anat Stemmer-Rachamimov

1 reference

16 September 2017

Chunling Yi

1 reference

16 September 2017

Erik W Wilker

1 reference

16 September 2017

Michael B Yaffe

1 reference

16 September 2017

Joseph L Kissil

1 reference

16 September 2017

language of work or name

English

0 references

publication date

1 October 2008

1 reference

16 September 2017

1 reference

16 September 2017

1 reference

16 September 2017

1 reference

16 September 2017

7932-7937

1 reference

Merlin/neurofibromatosis type 2 suppresses growth by inhibiting the activation of Ras and Rac.

16 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707059

Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707059

The genetic and molecular pathogenesis of NF1 and NF2.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707059

In vivo application of RNA interference: from functional genomics to therapeutics

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707059

The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707059

A clue to the therapy of neurofibromatosis type 2: NF2/merlin is a PAK1 inhibitor

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707059

Cyclic AMP-dependent protein kinase phosphorylates merlin at serine 518 independently of p21-activated kinase and promotes merlin-ezrin heterodimerization

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707059

Merlin, the Product of the Nf2 Tumor Suppressor Gene, Is an Inhibitor of the p21-Activated Kinase, Pak1

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707059

A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707059

p21-activated kinase links Rac/Cdc42 signaling to merlin

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707059

Conformational switch and role of phosphorylation in PAK activation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707059

The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707059

Kinase-Deficient Pak1 Mutants Inhibit Ras Transformation of Rat-1 Fibroblasts

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707059

Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707059

Cellular transformation by a FERM domain mutant of the Nf2 tumor suppressor gene

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707059

The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707059

Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707059

Regulatable Expression of p21-activated Kinase-1 Promotes Anchorage-independent Growth and Abnormal Organization of Mitotic Spindles in Human Epithelial Breast Cancer Cells

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707059

Upregulation of the Rac1/JNK signaling pathway in primary human schwannoma cells

2 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18829550

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Temporal control of Rac in Schwann cell-axon interaction is disrupted in NF2-mutant schwannoma cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18829550

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/0008-5472.CAN-08-0866

1 reference

16 September 2017

1 reference

16 September 2017

PubMed publication ID

18829550

1 reference