Epac, in synergy with cAMP-dependent protein kinase (PKA), is required for cAMP-mediated mitogenesis (Q40038631)

16 September 2017

title

Epac, in synergy with cAMP-dependent protein kinase (PKA), is required for cAMP-mediated mitogenesis (English)

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16 September 2017

Daniel Hochbaum

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16 September 2017

Kyoungja Hong

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16 September 2017

Guillermo Barila

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16 September 2017

Fernando Ribeiro-Neto

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16 September 2017

Daniel L Altschuler

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16 September 2017

language of work or name

English

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publication date

6 December 2007

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Journal of Biological Chemistry

16 September 2017

published in

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16 September 2017

volume

283

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16 September 2017

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16 September 2017

page(s)

4464-4468

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Inherited diseases involving g proteins and g protein-coupled receptors.

16 September 2017

cites work

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cAMP effector mechanisms. Novel twists for an 'old' signaling system

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Protein kinase A-dependent and -independent signaling pathways contribute to cyclic AMP-stimulated proliferation.

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Activation of Cyclic AMP-Dependent Kinase Is Required but May Not Be Sufficient To Mimic Cyclic AMP-Dependent DNA Synthesis and Thyroglobulin Expression in Dog Thyroid Cells

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Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

21 January 2018

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A family of cAMP-binding proteins that directly activate Rap1

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A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.

21 January 2018

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21 January 2018

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21 January 2018

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Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs

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Dynamic interaction of cAMP with the Rap guanine-nucleotide exchange factor Epac1.

21 January 2018

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Communication between the regulatory and the catalytic region of the cAMP-responsive guanine nucleotide exchange factor Epac

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Ligand-mediated activation of the cAMP-responsive guanine nucleotide exchange factor Epac

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Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state

21 January 2018

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Regulation of thyroid cell proliferation by TSH and other factors: a critical evaluation of in vitro models

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cAMP-dependent oncogenic action of Rap1b in the thyroid gland

21 January 2018

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On the mitogenic properties of Rap1b: cAMP-induced G(1)/S entry requires activated and phosphorylated Rap1b

21 January 2018

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Thyrotropin-dependent proliferation of in vitro rat thyroid cell systems

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Coordinated regulation of Rap1 and thyroid differentiation by cyclic AMP and protein kinase A.

21 January 2018

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cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension

21 January 2018

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21 January 2018

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The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.

21 January 2018

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Pleckstrin's repeat performance: a novel domain in G-protein signaling?

21 January 2018

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Structure and dynamics of the human pleckstrin DEP domain: distinct molecular features of a novel DEP domain subfamily

21 January 2018

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Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway

21 January 2018

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Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.C700171200

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16 September 2017

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