c-Jun-deficient cells undergo premature senescence as a result of spontaneous DNA damage accumulation. (Q40025608)

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3 January 2020

title

c-Jun-deficient cells undergo premature senescence as a result of spontaneous DNA damage accumulation (English)

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3 January 2020

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3 January 2020

Ann MacLaren

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3 January 2020

Elizabeth J Black

series ordinal

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3 January 2020

William Clark

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3 January 2020

language of work or name

English

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publication date

1 October 2004

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Molecular and Cellular Biology

3 January 2020

published in

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3 January 2020

volume

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3 January 2020

issue

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3 January 2020

page(s)

9006-9018

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AP-1: a double-edged sword in tumorigenesis

3 January 2020

cites work

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Permanent cell cycle exit in G2 phase after DNA damage in normal human fibroblasts.

22 September 2017

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Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

22 September 2017

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Werner syndrome protein limits MYC-induced cellular senescence

22 September 2017

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Roles of BRCA1 in DNA damage repair: a link between development and cancer

22 September 2017

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c-Myc directly regulates the transcription of the NBS1 gene involved in DNA double-strand break repair

22 September 2017

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Transcriptional activators stimulate DNA repair.

22 September 2017

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Toward maintaining the genome: DNA damage and replication checkpoints

22 September 2017

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ATM phosphorylates histone H2AX in response to DNA double-strand breaks

22 September 2017

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Dominant negative c-jun inhibits activation of the cyclin D1 and cyclin E kinase complexes

22 September 2017

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Cellular senescence: mitotic clock or culture shock?

22 September 2017

1 reference

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Inactivation of mouse Hus1 results in genomic instability and impaired responses to genotoxic stress

22 September 2017

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DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway

22 September 2017

1 reference

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Growth retardation, DNA repair defects, and lack of spermatogenesis in BRCA1-deficient mice

22 September 2017

1 reference

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Transcription-coupled repair of DNA damage: unanticipated players, unexpected complexities

22 September 2017

1 reference

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Control of cell cycle progression by c-Jun is p53 dependent

22 September 2017

1 reference

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c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms

22 September 2017

1 reference

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Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm-/- mice

22 September 2017

1 reference

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DNA damage induces phosphorylation of the amino terminus of p53

22 September 2017

1 reference

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Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

22 September 2017

1 reference

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Avian sarcoma virus 17 carries the jun oncogene

22 September 2017

1 reference

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Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun

22 September 2017

1 reference

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Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=517871

The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest

22 September 2017

1 reference

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Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF.

25 September 2017

1 reference

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p53 and c-Jun functionally synergize in the regulation of the DNA repair gene hMSH2 in response to UV.

25 September 2017

1 reference

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Mutagenesis by 8-oxoguanine: an enemy within

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=517871

v-Jun stimulates both cdk2 kinase activity and G1/S progression via transcriptional repression of p21 CIP1.

25 September 2017

1 reference

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Transient deactivation of ERK signalling is sufficient for stable entry into G0 in primary avian fibroblasts

15 June 2018

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Inhibition of the Jun kinase pathway blocks DNA repair, enhances p53-mediated apoptosis and promotes gene amplification

15 June 2018

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MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence.

15 June 2018

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Oxidative stress in cell culture: an under-appreciated problem?

20 August 2018

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The activation of c-Jun NH2-terminal kinase (JNK) by DNA-damaging agents serves to promote drug resistance via activating transcription factor 2 (ATF2)-dependent enhanced DNA repair

20 August 2018

1 reference

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Protective role for c-Jun in the cellular response to DNA damage

20 August 2018

1 reference

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The Jun kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin

20 August 2018

1 reference

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A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture

20 August 2018

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12 December 2020

Transformation by v-Jun prevents cell cycle exit and promotes apoptosis in the absence of serum growth factors

1 reference

12 December 2020

v-Jun sensitizes cells to apoptosis by a mechanism involving mitochondrial cytochrome C release

1 reference

12 December 2020

Recommendations for conducting the in vivo alkaline Comet assay. 4th International Comet Assay Workshop

1 reference

12 December 2020

10.1128/MCB.24.20.9006-9018.2004

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15456874%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15456874%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

PubMed publication ID

15456874

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15456874%20AND%20SRC:MED&resulttype=core&format=json