Early-Life Social Isolation Stress Increases Kappa Opioid Receptor Responsiveness and Downregulates the Dopamine System (Q40010691)

16 September 2017

Early-Life Social Isolation Stress Increases Kappa Opioid Receptor Responsiveness and Downregulates the Dopamine System (English)

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16 September 2017

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12 June 2020

Anushree N Karkhanis

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12 June 2020

Jamie H Rose

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12 June 2020

Jeffrey L Weiner

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12 June 2020

language of work or name

English

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publication date

10 February 2016

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16 September 2017

Neuropsychopharmacology

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12 June 2020

volume

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12 June 2020

issue

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12 June 2020

page(s)

2263-2274

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Supersensitive Kappa Opioid Receptors Promotes Ethanol Withdrawal-Related Behaviors and Reduce Dopamine Signaling in the Nucleus Accumbens.

12 June 2020

cites work

1 reference

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Social isolation rearing increases dopamine uptake and psychostimulant potency in the striatum

22 September 2017

1 reference

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Relative Timing Between Kappa Opioid Receptor Activation and Cocaine Determines the Impact on Reward and Dopamine Release

22 September 2017

1 reference

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Effects of acute and chronic social defeat stress are differentially mediated by the dynorphin/kappa-opioid receptor system

22 September 2017

1 reference

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Adolescent social isolation increases anxiety-like behavior and ethanol intake and impairs fear extinction in adulthood: Possible role of disrupted noradrenergic signaling.

22 September 2017

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Chronic intermittent ethanol exposure reduces presynaptic dopamine neurotransmission in the mouse nucleus accumbens.

22 September 2017

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Salvinorin A regulates dopamine transporter function via a kappa opioid receptor and ERK1/2-dependent mechanism.

22 September 2017

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Dopamine transporters govern diurnal variation in extracellular dopamine tone.

22 September 2017

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The role of kappa opioid receptors in stress-induced reinstatement of alcohol seeking in rats

22 September 2017

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Disrupted social development enhances the motivation for cocaine in rats

22 September 2017

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Long-term antagonism of κ opioid receptors prevents escalation of and increased motivation for heroin intake

22 September 2017

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22 September 2017

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The one-two punch of alcoholism: role of central amygdala dynorphins/kappa-opioid receptors

22 September 2017

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Effects of alcohol dependence and withdrawal on stress responsiveness and alcohol consumption

22 September 2017

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Examining the complex regulation and drug-induced plasticity of dopamine release and uptake using voltammetry in brain slices

22 September 2017

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The long-term impact of early adversity on late-life psychiatric disorders

22 September 2017

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Enduring increases in anxiety-like behavior and rapid nucleus accumbens dopamine signaling in socially isolated rats

22 September 2017

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Affective cue-induced escalation of alcohol self-administration and increased 22-kHz ultrasonic vocalizations during alcohol withdrawal: role of kappa-opioid receptors

22 September 2017

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Adolescent rearing conditions influence the relationship between initial anxiety-like behavior and ethanol drinking in male Long Evans rats

22 September 2017

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Increased dopamine receptor activity in the nucleus accumbens shell ameliorates anxiety during drug withdrawal

22 September 2017

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Targeting dynorphin/kappa opioid receptor systems to treat alcohol abuse and dependence

22 September 2017

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Demon voltammetry and analysis software: analysis of cocaine-induced alterations in dopamine signaling using multiple kinetic measures

22 September 2017

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How Addictive Drugs Disrupt Presynaptic Dopamine Neurotransmission

22 September 2017

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Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats

22 September 2017

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Extracellular fluctuations of dopamine and glutamate in the nucleus accumbens core and shell associated with lever-pressing during cocaine self-administration, extinction, and yoked cocaine administration

22 September 2017

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Depressive-like effects of the kappa opioid receptor agonist salvinorin A are associated with decreased phasic dopamine release in the nucleus accumbens

22 September 2017

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Ethanol-induced hyperactivity is associated with hypodopaminergia in the 22-TNJ ENU-mutated mouse

22 September 2017

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Footshock stress potentiates cue-induced cocaine-seeking in an animal model of relapse

22 September 2017

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The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors

22 September 2017

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Early social isolation in male Long-Evans rats alters both appetitive and consummatory behaviors expressed during operant ethanol self-administration.

22 September 2017

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Intermittent access to 20% ethanol induces high ethanol consumption in Long-Evans and Wistar rats

22 September 2017

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The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system

22 September 2017

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Effects of immobilization stress on neurochemical markers in the motivational system of the male rat

22 September 2017

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Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence

22 September 2017

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Voltammetric characterization of the effect of monoamine uptake inhibitors and releasers on dopamine and serotonin uptake in mouse caudate-putamen and substantia nigra slices.

22 September 2017

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Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs cocaine primes and its antidepressant-like effects in rats

22 September 2017

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Prior activation of kappa opioid receptors by U50,488 mimics repeated forced swim stress to potentiate cocaine place preference conditioning

22 September 2017

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A single injection of the kappa opioid antagonist norbinaltorphimine increases ethanol consumption in rats

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946054

Major coexpression of kappa-opioid receptors and the dopamine transporter in nucleus accumbens axonal profiles

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946054

The selective kappa-opioid receptor agonist U50,488H attenuates voluntary ethanol intake in the rat.

22 September 2017

1 reference

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Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946054

Social isolation rearing increases nucleus accumbens dopamine and norepinephrine responses to acute ethanol in adulthood.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946054

Repeated cycles of chronic intermittent ethanol exposure in mice increases voluntary ethanol drinking and ethanol concentrations in the nucleus accumbens

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946054

Comparison of local and systemic ethanol effects on extracellular dopamine concentration in rat nucleus accumbens by microdialysis

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946054

Dynorphin Is a Specific Endogenous Ligand of the κ Opioid Receptor

17 June 2018

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Exogenous tyrosine potentiates the methylphenidate-induced increase in extracellular dopamine in the nucleus accumbens: a microdialysis study

17 June 2018

1 reference

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Stress-induced changes in brain Met-enkephalin, Leu-enkephalin and dynorphin concentrations

17 June 2018

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Associations between adverse childhood experiences, psychological distress, and adult alcohol problems

17 June 2018

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Endogenous kappa-opioid mediation of stress-induced potentiation of ethanol-conditioned place preference and self-administration.

20 August 2018

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Effects of chronic alcohol exposure on dopamine uptake in rat nucleus accumbens and caudate putamen.

20 August 2018

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A microdialysis profile of dynorphin A(1-8) release in the rat nucleus accumbens following alcohol administration

20 August 2018

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Effects of subchronic methamphetamine exposure on basal dopamine and stress-induced dopamine release in the nucleus accumbens shell of rats

20 August 2018

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Voltammetric study of extracellular dopamine near microdialysis probes acutely implanted in the striatum of the anesthetized rat.

20 August 2018

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Enhanced dopamine uptake in the striatum following repeated restraint stress

20 August 2018

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Chronic ethanol exposure alters presynaptic dopamine function in the striatum of monkeys: a preliminary study

20 August 2018

1 reference

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Influence of postweaning social isolation in the rat on brain development, conditioned behavior, and neurotransmission

20 August 2018

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Adverse childhood experiences, alcoholic parents, and later risk of alcoholism and depression

20 August 2018

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Repeated ethanol administration induces short- and long-term changes in enkephalin and dynorphin tissue concentrations in rat brain

20 August 2018

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Kappa receptor regulation of dopamine release from striatum and cortex of rats and guinea pigs

20 August 2018

1 reference

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Voluntary ethanol intake in rats following exposure to ethanol on various schedules

20 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNPP.2016.21

31 March 2020

Identifiers

DOI

10.1038/NPP.2016.21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26860203%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

12 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26860203%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

PubMed publication ID

26860203

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26860203%20AND%20SRC:MED&resulttype=core&format=json