Sex Differences in Abdominal Aortic Aneurysms (Q49921149)

1 July 2019

title

Sex Differences in Abdominal Aortic Aneurysms (English)

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1 July 2019

author name string

Lin Chang

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1 July 2019

Ke-Jie Yin

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1 July 2019

Y Eugene Chen

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1 July 2019

Jean-Pyo Lee

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1 July 2019

Milton H Hamblin

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1 July 2019

Austin C Boese

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1 July 2019

publication date

19 January 2018

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1 July 2019

American Journal of Physiology Heart and Circulatory Physiology

published in

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1 July 2019

volume

314

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1 July 2019

issue

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1 July 2019

page(s)

H1137-H1152

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1 July 2019

Androgen-dependent angiotensinogen and renin messenger RNA expression in hypertensive rats

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Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation

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Estrogen regulates the IFN-gamma promoter

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Influence of contraceptive and other sex steroids on aortic collagen and elastin

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Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers.

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Gender difference in bioassayable endothelium-derived nitric oxide from isolated rat aortae

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Estrogen modulation of JE/monocyte chemoattractant protein-1 mRNA expression in murine macrophages

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Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung

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Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells

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Abdominal aortic aneurysm

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Enhanced production of the chemotactic cytokines interleukin-8 and monocyte chemoattractant protein-1 in human abdominal aortic aneurysms.

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Physiological concentration of 17 beta-estradiol inhibits chemotaxis of human monocytes in response to monocyte chemotactic protein 1

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Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic human pregnancy

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Gender differences in abdominal aortic aneurysm prevalence, treatment, and outcome

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Arterial expansive remodeling induced by high flow rates.

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Oxidative stress: oxidants and antioxidants

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Prostaglandin E2 synthesis and cyclooxygenase expression in abdominal aortic aneurysms

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Inflammation, metalloproteinases, and increased proteolysis: an emerging pathophysiological paradigm in aortic aneurysm

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12 December 2020

Elevated circulating levels of inflammatory cytokines in patients with abdominal aortic aneurysm

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12 December 2020

Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study

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Estrogen modulates AT1 receptor gene expression in vitro and in vivo

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Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors

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Aortic aneurysm formation: lessons from human studies and experimental models

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Evidence for a difference in nitric oxide biosynthesis between healthy women and men.

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Impact of gender on the renal response to angiotensin II.

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Estrogen regulates angiotensin AT1 receptor expression via cytosolic proteins that bind to the 5' leader sequence of the receptor mRNA

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Atherosclerosis is an inflammatory disease

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Endothelium-derived relaxing factor: discovery, early studies, and identification as nitric oxide

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Androgen receptor expression is greater in macrophages from male than from female donors. A sex difference with implications for atherogenesis

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The in situ conformation and axial location of the intermolecular cross-linked non-helical telopeptides of type I collagen

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12 December 2020

Abdominal aortic aneurysm: the role of clinical examination and opportunistic detection

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12 December 2020

The aneurysm detection and management study screening program: validation cohort and final results. Aneurysm Detection and Management Veterans Affairs Cooperative Study Investigators

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12 December 2020

Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice

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12 December 2020

Consistent production of a higher TH1:TH2 cytokine ratio by stimulated T cells in men compared with women

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12 December 2020

Estrogens and glucocorticoids inhibit endothelial vascular cell adhesion molecule-1 expression by different transcriptional mechanisms

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12 December 2020

A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase

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12 December 2020

17beta-estradiol prevents oxidative stress and decreases blood pressure in ovariectomized rats

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12 December 2020

Activity of matrix metalloproteinase-2 and -9 in abdominal aortic aneurysms. Relation to size and rupture

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12 December 2020

Postmenopausal changes in production of type 1 and type 2 cytokines and the effects of hormone replacement therapy

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12 December 2020

Ubiquitous Elevation of Matrix Metalloproteinase-2 Expression in the Vasculature of Patients With Abdominal Aneurysms

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12 December 2020

Nitric oxide synthases: structure, function and inhibition

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12 December 2020

Prevalence of and risk factors for abdominal aortic aneurysms in a population-based study : The Tromsø Study

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12 December 2020

Sex differences in autoimmune disease

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12 December 2020

Transient increase in the levels of T-helper 1 cytokines in postmenopausal women and the effects of hormone replacement therapy

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12 December 2020

Interferon-gamma levels are upregulated by 17-beta-estradiol and diethylstilbestrol

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12 December 2020

17beta-estradiol inhibition of NADPH oxidase expression in human endothelial cells

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12 December 2020

Critical role of tumor necrosis factor-alpha and NF-kappa B in interferon-gamma -induced CD40 expression in microglia/macrophages

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12 December 2020

The role of the renin-angiotensin system in the development of cardiovascular disease

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12 December 2020

In vivo evidence for antioxidant potential of estrogen in microvessels of female spontaneously hypertensive rats.

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12 December 2020

Abdominal aortic aneurysms: basic mechanisms and clinical implications

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12 December 2020

Natural killer cells express estrogen receptor-alpha and estrogen receptor-beta and can respond to estrogen via a non-estrogen receptor-alpha-mediated pathway

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12 December 2020

Oxidative stress in human abdominal aortic aneurysms: a potential mediator of aneurysmal remodeling.

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12 December 2020

Raloxifene improves endothelial dysfunction in hypertension by reduced oxidative stress and enhanced nitric oxide production

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12 December 2020

Estrogen alters thresholds for B cell apoptosis and activation

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12 December 2020

Abdominal aortic aneurysms: fresh insights from a novel animal model of the disease.

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12 December 2020

T(H)2 predominant immune responses prevail in human abdominal aortic aneurysm

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12 December 2020

Oxidative stress is involved in the development of experimental abdominal aortic aneurysm: a study of the transcription profile with complementary DNA microarray

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12 December 2020

Increased local angiotensin II formation in aneurysmal aorta

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12 December 2020

Androgen receptor-mediated inhibition of cutaneous wound healing.

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12 December 2020

Mechanical properties of adult vertebral cancellous bone: correlation with collagen intermolecular cross-links

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12 December 2020

Integration of the non-genomic and genomic actions of estrogen. Membrane-initiated signaling by steroid to transcription and cell biology

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12 December 2020

Possible roles of angiotensin II-forming enzymes, angiotensin converting enzyme and chymase-like enzyme, in the human aneurysmal aorta

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12 December 2020

Down-regulation of Rac-1 GTPase by Estrogen

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12 December 2020

Mechanism of endothelial cell NADPH oxidase activation by angiotensin II. Role of the p47phox subunit

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12 December 2020

Interactions between gender and the angiotensin type 1 receptor gene polymorphism

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12 December 2020

Estradiol enhances primary antigen-specific CD4 T cell responses and Th1 development in vivo. Essential role of estrogen receptor alpha expression in hematopoietic cells

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12 December 2020

Aortic dissection precedes formation of aneurysms and atherosclerosis in angiotensin II-infused, apolipoprotein E-deficient mice

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12 December 2020

17 Beta-estradiol attenuates development of angiotensin II-induced aortic abdominal aneurysm in apolipoprotein E-deficient mice

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12 December 2020

Inducible nitric oxide synthase is present in human abdominal aortic aneurysm and promotes oxidative vascular injury

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12 December 2020

Characterisation of T and B lymphocytes infiltrating abdominal aortic aneurysms.

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12 December 2020

[Effects of macrophage infiltration and related gene expression on the pathogenesis of early abdominal aortic aneurysm].

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12 December 2020

Gender differences in superoxide generation in microvessels of hypertensive rats: role of NAD(P)H-oxidase.

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12 December 2020

Key roles of CD4+ T cells and IFN-gamma in the development of abdominal aortic aneurysms in a murine model

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12 December 2020

Androgens augment proximal tubule transport

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12 December 2020

Orchidectomy, but not ovariectomy, regulates angiotensin II-induced vascular diseases in apolipoprotein E-deficient mice

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12 December 2020

A lower ratio of AT1/AT2 receptors of angiotensin II is found in female than in male spontaneously hypertensive rats

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12 December 2020

Gender differences in experimental aortic aneurysm formation

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12 December 2020

Estrogen modulates inflammatory mediator expression and neutrophil chemotaxis in injured arteries

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12 December 2020

Role of oxidative modifications in atherosclerosis

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12 December 2020

Enhanced expression of CD44 variants in human atheroma and abdominal aortic aneurysm: possible role for a feedback loop in endothelial cells

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12 December 2020

17beta-estradiol downregulates tissue angiotensin-converting enzyme and ANG II type 1 receptor in female rats

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12 December 2020

Treatment with 17-beta-estradiol reduces superoxide production in aorta of ovariectomized rats

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12 December 2020

Differential estrogen receptor gene expression in human peripheral blood mononuclear cell populations

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12 December 2020

Inhibitory effects of AT1 receptor blocker, olmesartan, and estrogen on atherosclerosis via anti-oxidative stress

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12 December 2020

MMP-12 has a role in abdominal aortic aneurysms in mice.

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12 December 2020

Suppression of experimental abdominal aortic aneurysms in mice by treatment with pyrrolidine dithiocarbamate, an antioxidant inhibitor of nuclear factor-kappaB.

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12 December 2020

Sex steroids modulate human aortic smooth muscle cell matrix protein deposition and matrix metalloproteinase expression

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12 December 2020

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12 December 2020

Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase

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12 December 2020

Predominance of type 1 CD4+ T cells in human abdominal aortic aneurysm.

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12 December 2020

Targeting prostaglandin E2 receptors as an alternative strategy to block cyclooxygenase-2-dependent extracellular matrix-induced matrix metalloproteinase-9 expression by macrophages

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12 December 2020

Matrix metalloproteinase-8 and -9 are increased at the site of abdominal aortic aneurysm rupture

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12 December 2020

Androgens modulate the inflammatory response during acute wound healing

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12 December 2020

Selective cyclooxygenase-2 inhibition with celecoxib decreases angiotensin II-induced abdominal aortic aneurysm formation in mice

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12 December 2020

Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases

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12 December 2020

Estrogen therapy replenishes vascular tetrahydrobiopterin and reduces oxidative stress in ovariectomized rats.

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12 December 2020

Early increased MT1-MMP expression and late MMP-2 and MMP-9 activity during Angiotensin II induced aneurysm formation

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12 December 2020

Gender differences in relative dilatation of abdominal aortic aneurysms

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12 December 2020

Conjugated equine estrogens and peripheral arterial disease risk: The Women's Health Initiative

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12 December 2020

Deletion of p47phox attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice

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12 December 2020

Effects of hormone replacement therapy on plasma pro-inflammatory and anti-inflammatory cytokines and some bone turnover markers in postmenopausal women

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12 December 2020

Angiotensin-converting enzyme inhibitors and aortic rupture: a population-based case-control study

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12 December 2020

IFN-gamma-inducing transcription factor, T-bet is upregulated by estrogen in murine splenocytes: role of IL-27 but not IL-12

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12 December 2020

Genetic deficiency of cyclooxygenase-2 attenuates abdominal aortic aneurysm formation in mice

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12 December 2020

Role of the renin-angiotensin system in the development of abdominal aortic aneurysms in animals and humans

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12 December 2020

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12 December 2020

Effect of oestrogen on reactive oxygen species production in the aortas of ovariectomized Dahl salt-sensitive rats

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12 December 2020

Role of oxidative stress in the pathogenesis of abdominal aortic aneurysms.

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12 December 2020

Estrogen modulates TNF-alpha-induced inflammatory responses in rat aortic smooth muscle cells through estrogen receptor-beta activation

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12 December 2020

Influence of sex on expansion rate of abdominal aortic aneurysms

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12 December 2020

The pro-inflammatory and chemotactic cytokine microenvironment of the abdominal aortic aneurysm wall: a protein array study

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12 December 2020

Sex differences in angiotensin II- induced hypertension

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12 December 2020

Differential regulation of thioredoxin and NAD(P)H oxidase by angiotensin II in male and female mice

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12 December 2020

MF-tricyclic inhibits growth of experimental abdominal aortic aneurysms

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12 December 2020

Mechanism of gender-specific differences in aortic stiffness with aging in nonhuman primates

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12 December 2020

Differential secretion of prostaglandin E(2), thromboxane A(2) and interleukin-6 in intact and ruptured abdominal aortic aneurysms

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12 December 2020

Type IV collagenases (MMP-2 and MMP-9) and their substrates--intracellular proteins, hormones, cytokines, chemokines and their receptors

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12 December 2020

Variant estrogen receptor-c-Src molecular interdependence and c-Src structural requirements for endothelial NO synthase activation

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12 December 2020

Orchidectomy increases the formation of prostanoids and modulates their role in the acetylcholine-induced relaxation in the rat aorta

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12 December 2020

Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction

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12 December 2020

Aortic aneurysms: an immune disease with a strong genetic component

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12 December 2020

NADPH oxidases, reactive oxygen species, and hypertension: clinical implications and therapeutic possibilities

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12 December 2020

Sex-differences in circadian blood pressure variations in response to chronic angiotensin II infusion in rats

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12 December 2020

Estrogen potentiates constrictor prostanoid function in female rat aorta by upregulation of cyclooxygenase-2 and thromboxane pathway expression

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12 December 2020

Androgen increases AT1a receptor expression in abdominal aortas to promote angiotensin II-induced AAAs in apolipoprotein E-deficient mice

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12 December 2020

Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies

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12 December 2020

Inhibition of reactive oxygen species attenuates aneurysm formation in a murine model

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12 December 2020

Raloxifene protects endothelial cell function against oxidative stress

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12 December 2020

The role of estrogen in the formation of experimental abdominal aortic aneurysm.

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12 December 2020

CD4 T cells: fates, functions, and faults

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12 December 2020

Abdominal aortic aneurysm events in the women's health initiative: cohort study

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12 December 2020

Dihydrotestosterone stimulates cerebrovascular inflammation through NFkappaB, modulating contractile function

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12 December 2020

Differential effect of 17-beta-estradiol on smooth muscle cell and aortic explant MMP2.

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12 December 2020

Biomarkers of AAA progression. Part 1: extracellular matrix degeneration

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12 December 2020

Delivery of sry1, but not sry2, to the kidney increases blood pressure and sns indices in normotensive wky rats

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12 December 2020

Circulating matrix metalloproteinase-9 concentrations and abdominal aortic aneurysm presence: a meta-analysis

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12 December 2020

Gender-dependent differential phosphorylation in the ERK signaling pathway is associated with increased MMP2 activity in rat aortic smooth muscle cells

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12 December 2020

Human mast cells express androgen receptors but treatment with testosterone exerts no influence on IgE-independent mast cell degranulation elicited by neuromuscular blocking agents

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12 December 2020

Decreased collagen and increased matrix metalloproteinase-13 in experimental abdominal aortic aneurysms in males compared with females

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12 December 2020

Nitric oxide induces the progression of abdominal aortic aneurysms through the matrix metalloproteinase inducer EMMPRIN.

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12 December 2020

Regulation of multiple renin-angiotensin system genes by Sry.

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12 December 2020

Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNF-alpha expression

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12 December 2020

Associations of total testosterone, sex hormone-binding globulin, calculated free testosterone, and luteinizing hormone with prevalence of abdominal aortic aneurysm in older men.

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12 December 2020

Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE-/- mice

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12 December 2020

Dihydrotestosterone alters cyclooxygenase-2 levels in human coronary artery smooth muscle cells

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12 December 2020

Androgen receptor-dependent activation of endothelial nitric oxide synthase in vascular endothelial cells: role of phosphatidylinositol 3-kinase/akt pathway

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12 December 2020

Nitric oxide and oxidative stress in vascular disease

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12 December 2020

Testosterone and coronary artery disease in men.

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12 December 2020

17beta-estradiol down-regulates lipopolysaccharide-induced MCP-1 production and cell migration in vascular smooth muscle cells.

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12 December 2020

Gender and the renin-angiotensin-aldosterone system

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12 December 2020

Increased levels of thioredoxin in patients with abdominal aortic aneurysms (AAAs). A potential link of oxidative stress with AAA evolution

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12 December 2020

Novel aspects of the pathogenesis of aneurysms of the abdominal aorta in humans

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12 December 2020

Tumor necrosis factor-α signaling in macrophages.

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12 December 2020

Estrogen, hormonal replacement therapy and cardiovascular disease

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12 December 2020

Sex differences in renal angiotensin converting enzyme 2 (ACE2) activity are 17β-oestradiol-dependent and sex chromosome-independent

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12 December 2020

Management of abdominal aortic aneurysms clinical practice guidelines of the European society for vascular surgery.

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12 December 2020

Analysis of aortic wall stress and rupture risk in patients with abdominal aortic aneurysm with a gender perspective

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12 December 2020

Circulating matrix metalloproteinases and their inhibitors in inguinal hernia and abdominal aortic aneurysm

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12 December 2020

Inhibition of Renin-Angiotensin System Reverses Endothelial Dysfunction and Oxidative Stress in Estrogen Deficient Rats

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12 December 2020

Resveratrol prevents the development of abdominal aortic aneurysm through attenuation of inflammation, oxidative stress, and neovascularization

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12 December 2020

Reproductive history in women with abdominal aortic aneurysms

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12 December 2020

Local and Systemic Alterations in Signal Transducers and Activators of Transcription (STAT) Associated with Human Abdominal Aortic Aneurysms

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12 December 2020

Complex pathologies of angiotensin II-induced abdominal aortic aneurysms

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12 December 2020

Estrogen receptor α signaling in T lymphocytes is required for estradiol-mediated inhibition of Th1 and Th17 cell differentiation and protection against experimental autoimmune encephalomyelitis.

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12 December 2020

The arterial depressor response to chronic low-dose angiotensin II infusion in female rats is estrogen dependent

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12 December 2020

Role of uncoupled endothelial nitric oxide synthase in abdominal aortic aneurysm formation: treatment with folic acid

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12 December 2020

Sex differences in the pressor and tubuloglomerular feedback response to angiotensin II.

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12 December 2020

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12 December 2020

Tetrahydrobiopterin improves endothelial function and decreases arterial stiffness in estrogen-deficient postmenopausal women

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12 December 2020

ACE2 gene polymorphism and essential hypertension: an updated meta-analysis involving 11,051 subjects

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12 December 2020

Increased JNK in males compared with females in a rodent model of abdominal aortic aneurysm

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12 December 2020

Transient exposure of neonatal female mice to testosterone abrogates the sexual dimorphism of abdominal aortic aneurysms

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12 December 2020

Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system

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12 December 2020

Biomarkers for Abdominal Aortic Aneurysms From a Sex Perspective

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12 December 2020

Estrogen modulates NFκB signaling by enhancing IκBα levels and blocking p65 binding at the promoters of inflammatory genes via estrogen receptor-β.

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12 December 2020

Src kinase-mediates androgen receptor-dependent non-genomic activation of signaling cascade leading to endothelial nitric oxide synthase

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12 December 2020

The role of extracellular signal-related kinase during abdominal aortic aneurysm formation

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12 December 2020

Androgen receptor influences on body defense system via modulation of innate and adaptive immune systems: lessons from conditional AR knockout mice

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12 December 2020

CD16(+) monocyte subsets are increased in large abdominal aortic aneurysms and are differentially related with circulating and cell-associated biochemical and inflammatory biomarkers

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12 December 2020

Gender differences in biomechanical properties, thrombus age, mass fraction and clinical factors of abdominal aortic aneurysms

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12 December 2020

The timing hypothesis and hormone replacement therapy: a paradigm shift in the primary prevention of coronary heart disease in women. Part 2: comparative risks

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12 December 2020

Is there a new target in the renin-angiotensin system for aortic aneurysm therapy?

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12 December 2020

Increased estrogen receptor alpha in experimental aortic aneurysms in females compared with males

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12 December 2020

Th1 cytokines are more effective than Th2 cytokines at licensing anti-tumour functions in CD40-activated human macrophages in vitro

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12 December 2020

Microvascular COX-2/mPGES-1/EP-4 axis in human abdominal aortic aneurysm.

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12 December 2020

eNOS uncoupling in cardiovascular diseases--the role of oxidative stress and inflammation

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12 December 2020

Phosphorylation of AKT and abdominal aortic aneurysm formation

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12 December 2020

Heart disease and stroke statistics--2014 update: a report from the American Heart Association

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12 December 2020

Castration of male mice prevents the progression of established angiotensin II-induced abdominal aortic aneurysms

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12 December 2020

Recoupling of eNOS with folic acid prevents abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E null mice

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12 December 2020

Monocyte activity is linked with abdominal aortic aneurysm diameter.

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12 December 2020

Gender differences in autoimmune disease

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12 December 2020

Estrogen effects on vascular inflammation are age dependent: role of estrogen receptors.

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12 December 2020

Androgens alter T-cell immunity by inhibiting T-helper 1 differentiation

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12 December 2020

Targets for medical therapy to limit abdominal aortic aneurysm progression.

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12 December 2020

TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord

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12 December 2020

Matrix metalloproteinase interactions with collagen and elastin

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12 December 2020

Association of testosterone with estrogen abolishes the beneficial effects of estrogen treatment by increasing ROS generation in aorta endothelial cells.

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12 December 2020

Testosterone induces leucocyte migration by NADPH oxidase-driven ROS- and COX2-dependent mechanisms.

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12 December 2020

Angiotensin II increases matrix metalloproteinase 2 expression in human aortic smooth muscle cells via AT1R and ERK1/2.

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12 December 2020

Aortic iron overload with oxidative stress and inflammation in human and murine abdominal aortic aneurysm

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12 December 2020

Androgen receptor modulates Foxp3 expression in CD4+CD25+Foxp3+ regulatory T-cells

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12 December 2020

Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation

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12 December 2020

Interleukin-12: Functional activities and implications for disease

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12 December 2020

Resveratrol inhibits TIGAR to promote ROS induced apoptosis and autophagy.

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12 December 2020

Reconsidering gender relative to risk of rupture in the contemporary management of abdominal aortic aneurysms

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12 December 2020

Differences in Elastin and Elastolytic Enzymes between Men and Women with Abdominal Aortic Aneurysm

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12 December 2020

The endothelial cyclooxygenase pathway: Insights from mouse arteries

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12 December 2020

Vascular Effects of Early versus Late Postmenopausal Treatment with Estradiol

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12 December 2020

Elastin-Derived Peptides Promote Abdominal Aortic Aneurysm Formation by Modulating M1/M2 Macrophage Polarization.

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12 December 2020

The composition of collagen in the aneurysm wall of men and women

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12 December 2020

Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System: A Scientific Statement From the American Heart Association

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12 December 2020

D-series resolvins inhibit murine abdominal aortic aneurysm formation and increase M2 macrophage polarization

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12 December 2020

10.1152/AJPHEART.00519.2017

Identifiers

DOI

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1 July 2019

PMC publication ID

6032079

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1 July 2019

PubMed publication ID

29350999

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1 July 2019