Bone morphogenetic protein 5 (Q4941570)

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mammalian protein found in Homo sapiens

• bone morphogenetic protein 5
• uniprot:P22003
• BMP5

edit

Language	Label	Description	Also known as
English	Bone morphogenetic protein 5	mammalian protein found in Homo sapiens	bone morphogenetic protein 5 uniprot:P22003 BMP5

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P22003

part of

Transforming growth factor-beta-related

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P22003

Cystine-knot cytokine

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P22003

Transforming growth factor-beta, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

TGF-beta, propeptide family

1 reference

based on heuristic

inferred from protein domain or family

Transforming growth factor beta, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P22003

encoded by

BMP5

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P22003

molecular function

cytokine activity

determination method or standard

IBA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P22003

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IBA

BMP receptor binding

determination method or standard

IDA

1 reference

retrieved

27 March 2018

stated in

A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22003&geneProductId=UniProtKB:P22003

determination method or standard

IDA

transforming growth factor beta receptor binding

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IBA

growth factor activity

determination method or standard

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P22003

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IEA

BMP receptor binding

determination method or standard

IBA

IDA

2 references

retrieved

8 April 2019

stated in

A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IBA

cell component

extracellular region

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P22003

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IEA

extracellular space

determination method or standard

IBA

IEA

ISS

4 references

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

ISS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P22003

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IBA

vesicle

determination method or standard

IEA

ISS

2 references

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

ISS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IEA

cellular component

determination method or standard

ND

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P22003

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

ND

biological process

regulation of apoptotic process

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IBA

pattern specification process

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IEA

skeletal system development

determination method or standard

NAS

IEA

2 references

retrieved

8 April 2019

stated in

Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone

GOA

curator

UniProt

UniProt protein ID

P22003

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

NAS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IEA

cell differentiation

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P22003

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IEA

male genitalia development

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IEA

regulation of MAPK cascade

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IBA

SMAD protein signal transduction

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IBA

ossification

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P22003

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IEA

positive regulation of epithelial cell proliferation

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IDA

negative regulation of mononuclear cell migration

determination method or standard

NAS

1 reference

retrieved

8 April 2019

stated in

The role of bone morphogenetic protein-5 (BMP-5) in human nephrosclerosis

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

NAS

negative regulation of cortisol biosynthetic process

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Bone morphogenetic proteins 2 and 5 are down-regulated in adrenocortical carcinoma and modulate adrenal cell proliferation and steroidogenesis

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IDA

positive regulation of pathway-restricted SMAD protein phosphorylation

determination method or standard

IDA

1 reference

retrieved

27 March 2018

stated in

Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22003&geneProductId=UniProtKB:P22003

determination method or standard

IDA

positive regulation of dendrite development

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IDA

BMP signaling pathway

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IBA

multicellular organism development

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P22003

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IEA

cartilage development

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P22003

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IEA

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

determination method or standard

NAS

1 reference

retrieved

8 April 2019

stated in

The role of bone morphogenetic protein-5 (BMP-5) in human nephrosclerosis

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

NAS

negative regulation of insulin-like growth factor receptor signaling pathway

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Bone morphogenetic proteins 2 and 5 are down-regulated in adrenocortical carcinoma and modulate adrenal cell proliferation and steroidogenesis

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IDA

type B pancreatic cell development

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IDA

negative regulation of steroid biosynthetic process

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Bone morphogenetic proteins 2 and 5 are down-regulated in adrenocortical carcinoma and modulate adrenal cell proliferation and steroidogenesis

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IDA

negative regulation of epithelial to mesenchymal transition

determination method or standard

NAS

1 reference

retrieved

8 April 2019

stated in

The role of bone morphogenetic protein-5 (BMP-5) in human nephrosclerosis

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

NAS

positive regulation of transcription by RNA polymerase II

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IDA

negative regulation of cell population proliferation

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Bone morphogenetic proteins 2 and 5 are down-regulated in adrenocortical carcinoma and modulate adrenal cell proliferation and steroidogenesis

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IDA

negative regulation of aldosterone biosynthetic process

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Bone morphogenetic proteins 2 and 5 are down-regulated in adrenocortical carcinoma and modulate adrenal cell proliferation and steroidogenesis

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IDA

endocardial cushion formation

determination method or standard

IEA

ISS

2 references

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

ISS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IEA

pericardium morphogenesis

determination method or standard

IEA

ISS

2 references

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

ISS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IEA

neural fold elevation formation

determination method or standard

IEA

ISS

2 references

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

ISS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IEA

hindbrain development

determination method or standard

IEA

ISS

2 references

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

ISS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IEA

cardiac muscle tissue development

determination method or standard

IEA

ISS

2 references

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

ISS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IEA

pharyngeal system development

determination method or standard

IEA

ISS

2 references

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

ISS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IEA

cardiac septum morphogenesis

determination method or standard

IEA

ISS

2 references

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

ISS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IEA

chorio-allantoic fusion

determination method or standard

IEA

ISS

2 references

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

ISS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IEA

heart trabecula morphogenesis

determination method or standard

IEA

ISS

2 references

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

ISS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IEA

allantois development

determination method or standard

IEA

ISS

2 references

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

ISS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IEA

regulation of signaling receptor activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IEA

ear development

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IEA

anterior head development

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IEA

positive regulation of cell population proliferation

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IDA

positive regulation of pathway-restricted SMAD protein phosphorylation

determination method or standard

IBA

IDA

2 references

retrieved

8 April 2019

stated in

Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IBA

cell development

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22003

determination method or standard

IBA

Gene Atlas image

PBB GE BMP5 205431 s at fs.png
732 × 530; 11 KB

0 references

exact match

http://purl.uniprot.org/uniprot/P22003

1 reference

stated in

Identifiers.org

has part(s)

Transforming growth factor-beta, C-terminal

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P22003

TGF-beta, propeptide

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P22003

Transforming growth factor beta, conserved site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P22003

Identifiers

MeSH descriptor ID

D055417

subject named as

Bone Morphogenetic Protein 5

0 references

MeSH tree code

D12.644.276.954.200.500

0 references

D12.776.467.942.200.500

0 references

D23.529.942.200.500

0 references

RefSeq protein ID

NP_001316683

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

653

NP_001316685

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

653

NP_066551

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

653

XP_011513119

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

653

XP_024302292

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

653

UniProt protein ID

P22003

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P22003

Ensembl protein ID

ENSP00000359866

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000359866

UMLS CUI

C0537464

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

stated in

UMLS 2023

retrieved

25 May 2023

 

Sitelinks

Wikipedia(0 entries)

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Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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