Protection against ischemia-induced neuronal damage by the alpha 2-adrenoceptor antagonist idazoxan: influence of time of administration and possible mechanisms of action (Q48874352)

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English	Protection against ischemia-induced neuronal damage by the alpha 2-adrenoceptor antagonist idazoxan: influence of time of administration and possible mechanisms of action	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/1976642

Protection against ischemia-induced neuronal damage by the alpha 2-adrenoceptor antagonist idazoxan: influence of time of administration and possible mechanisms of action (English)

1 reference

Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/1976642

author name string

Gustafson I

1

1 reference

Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/1976642

Westerberg E

2

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Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/1976642

Wieloch T

3

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Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/1976642

publication date

1 November 1990

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Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/1976642

Journal of Cerebral Blood Flow & Metabolism

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Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/1976642

10

1 reference

Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/1976642

6

1 reference

Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/1976642

885-894

1 reference

Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/1976642

Evidence for norepinephrine-mediated collateral inhibition of locus coeruleus neurons

1 reference

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Hypoglycemic brain injury in the rat. Correlation of density of brain damage with the EEG isoelectric time: a quantitative study

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Noradrenaline inhibition of acetylcholine release from guinea-pig brain

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Delayed postischemic hypoperfusion: evidence against involvement of the noradrenergic locus ceruleus system.

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Lesions of the locus coeruleus system aggravate ischemic damage in the rat brain

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Quantitative autoradiography of [3H]-MK-801 binding sites in mammalian brain

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Light microscopic autoradiographic localisation of [3H]glycine and [3H]strychnine binding sites in rat brain.

1 reference

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21 January 2018

Ischemia-induced changes in the electrical activity of the hippocampus.

1 reference

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Heterogeneity of alpha-2 adrenergic receptors

1 reference

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Noradrenergic neurons of the locus coeruleus: inhibition by epinephrine and activation by the α-antagonist piperoxane

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Activation of locus coeruleus neurons by peripheral stimuli: Modulation by a collateral inhibitory mechanism

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Glutamate neurotoxicity and diseases of the nervous system

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High affinity binding of 3H rauwolscine and 3H RX781094 to alpha 2 adrenergic receptors and non-stereoselective sites in human and rabbit brain cortex membranes

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Inhibitory effects of noradrenaline and dopamine on calcium influx and neurotransmitter glutamate release in mammalian brain slices

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Studies on RX 781094: a selective, potent and specific antagonist of α2-adrenoceptors

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Presynaptic Alpha-Adrenoceptors in the Central Nervous System

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Amphetamine, haloperidol, and experience interact to affect rate of recovery after motor cortex injury

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Idazoxan (RX 781094) selectively antagonizes α2-adrenoceptors on rat central neurons

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Direct evidence for acute and massive norepinephrine release in the hippocampus during transient ischemia

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Lesioning of serotoninergic and noradrenergic nerve fibres of the rat brain does not decrease binding of 3H-clonidine and 3H-rauwolscine to cortical membranes

1 reference

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[3H]yohimbine and [3H]idazoxan bind to different sites on rabbit forebrain and kidney membranes

1 reference

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Chemical Anatomy of the Brain

1 reference

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Amphetamine with experience promotes recovery of locomotor function after unilateral frontal cortex injury in the cat.

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Delayed neuronal death in the gerbil hippocampus following ischemia

1 reference

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Circulating catecholamines modulate ischemic brain damage.

1 reference

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Actions of noradrenaline recorded intracellularly in rat hippocampal CA1 pyramidal neurones, in vitro

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Norepinephrine decreases synaptic inhibition in the rat hippocampus.

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Catecholamines and convulsions

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Anatomical distributions of four pharmacologically distinct 3H-L-glutamate binding sites

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Noradrenergic depression of synaptic responses in hippocampus of rat: evidence for mediation by alpha 1-receptors

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Mechanisms of epileptic brain damage: evidence for a protective role of the noradrenergic locus coeruleus system in the rat.

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Rapid reduction in [3H]prazosin binding to gerbil forebrain membranes during bilateral common carotid artery occlusion

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Differential effects of norepinephrine on hippocampal complex-spike and theta-neurons

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Comparison of the effects of recently developed alpha 2-adrenergic antagonists with yohimbine and rauwolscine on monoamine synthesis in rat brain

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3HRX 781094: A new antagonist ligand labels α2-adrenoceptors in the rat brain cortex

1 reference

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GABAergic nerve terminals in rat hippocampus possess alpha 2-adrenoceptors regulating GABA release

1 reference

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Temporal profile of neuronal damage in a model of transient forebrain ischemia

1 reference

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Regional cerebral blood flow and glucose metabolism following transient forebrain ischemia

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Glutamate and the pathophysiology of hypoxic--ischemic brain damage

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Effect of theophylline on ischemically induced hippocampal damage in Mongolian gerbils: a behavioral and histopathological study

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Glucocorticoids potentiate ischemic injury to neurons: therapeutic implications

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The action of norepinephrine in the rat hippocampus. III. Hippocampal cellular responses to locus coeruleus stimulation in the awake rat

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Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

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Models for studying long-term recovery following forebrain ischemia in the rat. 2. A 2-vessel occlusion model

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Inhibition of both noradrenergic and serotonergic neurons in brain by the α-adrenergic agonist clonidine

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Further evidence for a central stimulatory action of catecholamines on adrenocorticotropin release in the rat.

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Effects of idazoxan on catecholamine systems in rat brain

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Role of brain monoamines and histamine in regulation of anterior pituitary secretion

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Neurochemical correlates to selective neuronal vulnerability

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High affinity binding of idazoxan to a non-catecholaminergic binding site in the central nervous system: description of a putative idazoxan-receptor

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Noradrenergic alpha 1 and alpha 2 receptors: light microscopic autoradiographic localization

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Evidence that amphetamine with physical therapy promotes recovery of motor function in stroke patients

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Cerebral blood flow and oxygen consumption in the rat brain after lesions of the noradrenergic locus coeruleus system

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Regulation of the release of neuronally localized corticosterone in rat forebrain areas by catecholamines

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Clonidine binds to imidazole binding sites as well as alpha 2-adrenoceptors in the ventrolateral medulla

1 reference

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Effects of neurotransmitters on the release of corticotropin releasing hormone (CRH) by rat hypothalamic tissue in vitro

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Noradrenaline inhibits depolarization-induced 3H-serotonin release from slices of rat hippocampus

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.1990.145

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Postischemic administration of idazoxan, an alpha-2 adrenergic receptor antagonist, decreases neuronal damage in the rat brain

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.1990.145

7 January 2021

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Preischemic hyperglycemia enhances postischemic depression of cerebral metabolic rate

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Measurement of endogenous noradrenaline release in the rat cerebral cortex in vivo by transcortical dialysis: effects of drugs affecting noradrenergic transmission

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The glutamate antagonist MK-801 reduces focal ischemic brain damage in the rat

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The organization of noradrenergic pathways from the brainstem to the paraventricular and supraoptic nuclei in the rat.

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Alpha-2 receptor blockade increases responsiveness of locus coeruleus neurons to excitatory stimulation

1 reference

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The density and distribution of ischemic brain injury in the rat following 2?10 min of forebrain ischemia

1 reference

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7 January 2021

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10.1038/JCBFM.1990.145

1 reference

Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/1976642

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/1976642

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