Enhancer Remodeling during Adaptive Bypass to MEK Inhibition Is Attenuated by Pharmacologic Targeting of the P-TEFb Complex (Q48863076)

23 May 2018

title

Enhancer Remodeling during Adaptive Bypass to MEK Inhibition Is Attenuated by Pharmacologic Targeting of the P-TEFb Complex (English)

1 reference

23 May 2018

Charles M Perou

1 reference

23 May 2018

Jon S Zawistowski

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23 May 2018

Samantha M Bevill

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23 May 2018

Daniel R Goulet

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23 May 2018

Timothy J Stuhlmiller

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23 May 2018

Adriana S Beltran

1 reference

23 May 2018

Jose F Olivares-Quintero

1 reference

23 May 2018

Darshan Singh

1 reference

23 May 2018

Noah Sciaky

1 reference

23 May 2018

Joel S Parker

1 reference

23 May 2018

Naim U Rashid

1 reference

23 May 2018

Xin Chen

1 reference

23 May 2018

James S Duncan

1 reference

23 May 2018

Martin C Whittle

1 reference

23 May 2018

Steven P Angus

1 reference

23 May 2018

Sara Hanna Velarde

1 reference

23 May 2018

Brian T Golitz

1 reference

23 May 2018

Xiaping He

1 reference

23 May 2018

Charlene Santos

1 reference

23 May 2018

David B Darr

1 reference

23 May 2018

Kristalyn Gallagher

1 reference

23 May 2018

Lee M Graves

1 reference

23 May 2018

Lisa A Carey

1 reference

23 May 2018

H Shelton Earp

1 reference

23 May 2018

Gary L Johnson

1 reference

23 May 2018

publication date

20 January 2017

1 reference

23 May 2018

published in

Cancer Discovery

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23 May 2018

volume

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23 May 2018

issue

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23 May 2018

page(s)

302-321

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23 May 2018

Mediator Undergoes a Compositional Change during Transcriptional Activation.

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Brd4 activates P-TEFb for RNA polymerase II CTD phosphorylation

25 May 2018

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Enhancer-targeted genome editing selectively blocks innate resistance to oncokinase inhibition

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Concurrent MEK2 mutation and BRAF amplification confer resistance to BRAF and MEK inhibitors in melanoma

25 May 2018

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25 May 2018

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Cross-talk among RNA polymerase II kinases modulates C-terminal domain phosphorylation

25 May 2018

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Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations

25 May 2018

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25 May 2018

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25 May 2018

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Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer

25 May 2018

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25 May 2018

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The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.

25 May 2018

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Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K

25 May 2018

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25 May 2018

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25 May 2018

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25 May 2018

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25 May 2018

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25 May 2018

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25 May 2018

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25 May 2018

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A novel tyrosine kinase switch is a mechanism of imatinib resistance in gastrointestinal stromal tumors

25 May 2018

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25 May 2018

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Association of the Mediator complex with enhancers of active genes

25 May 2018

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25 May 2018

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25 May 2018

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25 May 2018

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25 May 2018

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25 May 2018

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Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.

14 August 2018

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Latent enhancers activated by stimulation in differentiated cells

14 August 2018

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14 August 2018

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10.1158/2159-8290.CD-16-0653

14 August 2018

Identifiers

DOI

1 reference

23 May 2018

PMC publication ID

5340640

1 reference

23 May 2018

PubMed publication ID

28108460

1 reference

23 May 2018