Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice (Q48459353)

11 February 2018

title

Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice (English)

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11 February 2018

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Demian Obregon

object named as

Demian Obregon

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11 February 2018

Richard Flavell

object named as

Richard A Flavell

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11 February 2018

author name string

Jun Tan

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11 February 2018

Terrence Town

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Fiona Crawford

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11 February 2018

Takashi Mori

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11 February 2018

Anthony DelleDonne

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11 February 2018

Robert Crescentini

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11 February 2018

language of work or name

English

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publication date

1 December 2002

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11 February 2018

published in

Nature Neuroscience

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11 February 2018

volume

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11 February 2018

issue

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11 February 2018

page(s)

1288-1293

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11 February 2018

Alzheimer's disease: genes, proteins, and therapy

cites work

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Microglia and the immune pathology of Alzheimer disease

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Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E.

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Activation of microglial cells by beta-amyloid protein and interferon-gamma.

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CD40 AND CD154 IN CELL-MEDIATED IMMUNITY

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7 January 2021

Post-transcriptional inhibition of CD40 gene expression in microglia by transforming growth factor-beta

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Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation.

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7 January 2021

Identification of CD40 ligand in Alzheimer's disease and in animal models of Alzheimer's disease and brain injury

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7 January 2021

Expression of CD40 in the brain of Alzheimer's disease and other neurological diseases

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1.

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7 January 2021

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

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Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice

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7 January 2021

A new definition of Alzheimer's disease: a hippocampal dementia

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7 January 2021

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

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7 January 2021

CD40 is expressed and functional on neuronal cells

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7 January 2021

Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

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7 January 2021

Ligation of CD40 activates interleukin 1beta-converting enzyme (caspase-1) activity in vascular smooth muscle and endothelial cells and promotes elaboration of active interleukin 1beta

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7 January 2021

Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for CD40-CD40 ligand signaling in atherosclerosis

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Role of CD40-CVD40L in mouse severe malaria

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Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

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Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease

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7 January 2021

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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7 January 2021

Number of Abeta inoculations in APP+PS1 transgenic mice influences antibody titers, microglial activation, and congophilic plaque levels

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Intrahippocampal LPS injections reduce Abeta load in APP+PS1 transgenic mice

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7 January 2021

Neuroinflammation-induced acceleration of amyloid deposition in the APPV717F transgenic mouse

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7 January 2021

Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.

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7 January 2021

The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse.

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7 January 2021

Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice.

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Mice deficient for the CD40 ligand

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7 January 2021

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

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7 January 2021

Identifiers

DOI

10.1038/NN968

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11 February 2018

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11 February 2018