Combined VEGF and PDGF inhibition for neovascular AMD: anti-angiogenic properties of axitinib on human endothelial cells and pericytes in vitro. (Q48276388)

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scientific article published on 4 February 2017

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English	Combined VEGF and PDGF inhibition for neovascular AMD: anti-angiogenic properties of axitinib on human endothelial cells and pericytes in vitro.	scientific article published on 4 February 2017

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scholarly article

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1 April 2020

Combined VEGF and PDGF inhibition for neovascular AMD: anti-angiogenic properties of axitinib on human endothelial cells and pericytes in vitro (English)

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1 April 2020

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angiogenesis inhibitor

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Jakob Siedlecki

1

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1 April 2020

Christian Wertheimer

2

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1 April 2020

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Armin Wolf

3

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1 April 2020

Raffael Liegl

4

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1 April 2020

Claudia Priglinger

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1 April 2020

Siegfried Priglinger

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1 April 2020

Kirsten Eibl-Lindner

7

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1 April 2020

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4 February 2017

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1 April 2020

Graefe's Archive for Clinical and Experimental Ophthalmology

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1 April 2020

255

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1 April 2020

5

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1 April 2020

963-972

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1 April 2020

Prevalence of age-related macular degeneration in the United States

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21 January 2018

Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis.

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21 January 2018

Subfoveal choroidal neovascular membranes in age-related macular degeneration. Visual prognosis in eyes with relatively good initial visual acuity

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21 January 2018

Increased expression of angiogenic growth factors in age-related maculopathy

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21 January 2018

Ranibizumab for neovascular age-related macular degeneration

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21 January 2018

Ranibizumab versus verteporfin for neovascular age-related macular degeneration.

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21 January 2018

Ranibizumab and bevacizumab for neovascular age-related macular degeneration

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21 January 2018

Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration.

1 reference

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21 January 2018

Non-responders to treatment with antagonists of vascular endothelial growth factor in age-related macular degeneration

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21 January 2018

Seven-year outcomes in ranibizumab-treated patients in ANCHOR, MARINA, and HORIZON: a multicenter cohort study (SEVEN-UP).

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21 January 2018

Intraocular growth factors and cytokines in patients with dry and neovascular age-related macular degeneration

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21 January 2018

A Phase 1 Study of Intravitreous E10030 in Combination with Ranibizumab in Neovascular Age-Related Macular Degeneration.

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21 January 2018

Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus

1 reference

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21 January 2018

cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines

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21 January 2018

PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor

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21 January 2018

PDGF-D, a new protease-activated growth factor

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21 January 2018

Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity

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21 January 2018

Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors

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21 January 2018

Endothelial/pericyte interactions

1 reference

https://api.crossref.org/works/10.1007%2FS00417-017-3595-Z

21 January 2018

Endothelial-mural cell signaling in vascular development and angiogenesis

1 reference

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21 January 2018

Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal

1 reference

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21 January 2018

Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression

1 reference

https://api.crossref.org/works/10.1007%2FS00417-017-3595-Z

21 January 2018

Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation

1 reference

https://api.crossref.org/works/10.1007%2FS00417-017-3595-Z

21 January 2018

Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells

1 reference

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21 January 2018

Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity

1 reference

https://api.crossref.org/works/10.1007%2FS00417-017-3595-Z

21 January 2018

Ranibizumab treatment in age-related macular degeneration: a meta-analysis of one-year results

1 reference

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21 January 2018

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

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21 January 2018

Inhibition of platelet-derived growth factor B signaling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization

1 reference

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21 January 2018

Axitinib inhibits retinal and choroidal neovascularization in in vitro and in vivo models

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21 January 2018

Axitinib (AG-013736).

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21 January 2018

Ranibizumab inhibits multiple forms of biologically active vascular endothelial growth factor in vitro and in vivo

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21 January 2018

Comparative effects of bevacizumab, ranibizumab and pegaptanib at intravitreal dose range on endothelial cells.

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21 January 2018

Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters

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21 January 2018

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

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21 January 2018

The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes

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21 January 2018

Basic and therapeutic aspects of angiogenesis

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21 January 2018

Aflibercept therapy for exudative age-related macular degeneration resistant to bevacizumab and ranibizumab.

1 reference

https://api.crossref.org/works/10.1007%2FS00417-017-3595-Z

21 January 2018

Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3.

1 reference

https://api.crossref.org/works/10.1007%2FS00417-017-3595-Z

21 January 2018

Novel insights into pericyte-myofibroblast transition and therapeutic targets in renal fibrosis

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21 January 2018

Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling

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21 January 2018

What is the evidence for systemic effects of intravitreal anti-VEGF agents, and should we be concerned?

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21 January 2018

Systemic pharmacokinetics following intravitreal injections of ranibizumab, bevacizumab or aflibercept in patients with neovascular AMD

1 reference

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21 January 2018

Multikinase inhibitors as a new approach in neovascular age-related macular degeneration (AMD) treatment: in vitro safety evaluations of axitinib, pazopanib and sorafenib for intraocular use

1 reference

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21 January 2018

Antiangiogenic effects of axitinib, an inhibitor of vascular endothelial growth factor receptor tyrosine kinase, on laser-induced choroidal neovascularization in mice

1 reference

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21 January 2018

Apoptosis in surgically excised choroidal neovascular membranes in age-related macular degeneration.

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21 January 2018

Regulation of PDGF and its receptors in fibrotic diseases

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21 January 2018

Role of growth factors and the wound healing response in age-related macular degeneration

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21 January 2018

Intraocular injection of an aptamer that binds PDGF-B: a potential treatment for proliferative retinopathies

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21 January 2018

Risk of scar in the comparison of age-related macular degeneration treatments trials

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21 January 2018

Molecular mechanisms of subretinal fibrosis in age-related macular degeneration.

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21 January 2018

Subfoveal fibrosis in eyes with neovascular age-related macular degeneration treated with intravitreal ranibizumab.

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21 January 2018

Hypoxic regulation of vascular endothelial growth factor in retinal cells

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28161830

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diastolic Blood Pressure as a Biomarker of Axitinib Efficacy in Solid Tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/28161830

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Axitinib modulates hypoxia-induced blood-retina barrier permeability and expression of growth factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/28161830

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Global data on visual impairment in the year 2002

1 reference

https://pubmed.ncbi.nlm.nih.gov/28161830

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related macular degeneration is the leading cause of blindness...

1 reference

https://pubmed.ncbi.nlm.nih.gov/28161830

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of a flexible visual acuity-driven ranibizumab treatment regimen in age-related macular degeneration: outcomes of a drug and disease model

1 reference

https://pubmed.ncbi.nlm.nih.gov/28161830

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of VEGF in perivascular cells defines a potential paracrine mechanism for endothelial cell survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/28161830

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothelial growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/28161830

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histopathologic and ultrastructural findings of surgically excised choroidal neovascularization. Submacular Surgery Trials Research Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/28161830

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/28161830

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR

1 reference

https://pubmed.ncbi.nlm.nih.gov/28161830

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/28161830

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Basic fibroblast growth factor and vascular endothelial growth factor are present in epiretinal and choroidal neovascular membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/28161830

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular endothelial growth factor family and receptor expression in human choroidal neovascular membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/28161830

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00417-017-3595-Z

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28161830%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28161830%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

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