Engineering antibody Fv fragments for cancer detection and therapy: disulfide-stabilized Fv fragments (Q47960256)

7 February 2018

review article

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title

Engineering antibody Fv fragments for cancer detection and therapy: disulfide-stabilized Fv fragments (English)

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7 February 2018

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Reiter Y

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7 February 2018

Brinkmann U

series ordinal

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7 February 2018

Lee B

series ordinal

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7 February 2018

Pastan I

series ordinal

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7 February 2018

publication date

1 October 1996

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7 February 2018

published in

Nature Biotechnology

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7 February 2018

volume

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7 February 2018

issue

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7 February 2018

page(s)

1239-1245

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7 February 2018

Immunotoxins: magic bullets or misguided missiles?

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Immunotoxins against cancer

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A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin

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Thermal stabilization of a single-chain Fv antibody fragment by introduction of a disulphide bond

21 January 2018

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Preparation and characterization of a disulfide-stabilized Fv fragment of the anti-Tac antibody: comparison with its single-chain analog

21 January 2018

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Phage display of disulfide-stabilized Fv fragments

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Recombinant immunotoxin containing a disulfide-stabilized Fv directed at erbB2 that does not require proteolytic activation

21 January 2018

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Improved antitumor activity of a recombinant anti-Lewis(y) immunotoxin not requiring proteolytic activation

21 January 2018

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The multichain interleukin-2 receptor: a target for immunotherapy

21 January 2018

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Single-chain immunotoxins directed at the human transferrin receptor containing Pseudomonas exotoxin A or diphtheria toxin: anti-TFR(Fv)-PE40 and DT388-anti-TFR(Fv).

21 January 2018

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Correctly Folded T-cell Receptor Fragments in the Periplasm of Escherichia coli

21 January 2018

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Continuous cultures of fused cells secreting antibody of predefined specificity

21 January 2018

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7 January 2021

Recombinant Toxins for Cancer Treatment

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7 January 2021

Recombinant toxins as novel therapeutic agents

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7 January 2021

Single-chain antigen-binding proteins

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7 January 2021

Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli

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7 January 2021

Assembly of a functional immunoglobulin Fv fragment in Escherichia coli

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7 January 2021

Synthetic human antibodies

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7 January 2021

Human antibodies from combinatorial libraries.

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7 January 2021

https://api.crossref.org/works/10.1038%2FNBT1096-1239

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7 January 2021

A recombinant immunotoxin containing a disulfide-stabilized Fv fragment

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7 January 2021

Engineering interchain disulfide bonds into conserved framework regions of Fv fragments: improved biochemical characteristics of recombinant immunotoxins containing disulfide-stabilized Fv.

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7 January 2021

Structure of exotoxin A of Pseudomonas aeruginosa at 3.0-Angstrom resolution

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7 January 2021

Analysis of Pseudomonas exotoxin activation and conformational changes by using monoclonal antibodies as probes

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7 January 2021

3 Protein engineering of single-chain Fv analogs and fusion proteins

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7 January 2021

Innovative developments in isotachophoresis (displacement electrophoresis).

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7 January 2021

B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice

1 reference

https://api.crossref.org/works/10.1038%2FNBT1096-1239

7 January 2021

Recombinant anti-erbB2 immunotoxins containing Pseudomonas exotoxin

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7 January 2021

Design of interchain disulfide bonds in the framework region of the Fv fragment of the monoclonal antibody B3

1 reference

https://api.crossref.org/works/10.1038%2FNBT1096-1239

7 January 2021

A comparison of strategies to stabilize immunoglobulin Fv-fragments

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https://api.crossref.org/works/10.1038%2FNBT1096-1239

7 January 2021

Humanization of an anti-p185HER2 antibody for human cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FNBT1096-1239

7 January 2021

Stabilization of the Fv fragments in recombinant immunotoxins by disulfide bonds engineered into conserved framework regions

1 reference

https://api.crossref.org/works/10.1038%2FNBT1096-1239

7 January 2021

Rapid and efficient site-specific mutagenesis without phenotypic selection

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7 January 2021

Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

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7 January 2021

A method for increasing the yield of properly folded recombinant fusion proteins: single-chain immunotoxins from renaturation of bacterial inclusion bodies

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7 January 2021

Administration of disulfide-stabilized Fv-immunotoxins B1(dsFv)-PE38 and B3(dsFv)-PE38 by continuous infusion increases their efficacy in curing large tumor xenografts in nude mice

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7 January 2021

Construction of a functional disulfide-stabilized TCR Fv indicates that antibody and tcr fv frameworks are very similar in structure

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7 January 2021

Crystal structure of the beta chain of a T cell antigen receptor

1 reference

https://api.crossref.org/works/10.1038%2FNBT1096-1239

7 January 2021

Recombinant single-chain and disulfide-stabilized Fv-immunotoxins that cause complete regression of a human colon cancer xenograft in nude mice.

1 reference

https://api.crossref.org/works/10.1038%2FNBT1096-1239

7 January 2021

Cloning, expression and characterization of the Fv fragments of the anti-carbohydrate mAbs B1 and B5 as single-chain immunotoxins

1 reference

https://api.crossref.org/works/10.1038%2FNBT1096-1239

7 January 2021

The recombinant immunotoxin anti-Tac(Fv)-Pseudomonas exotoxin 40 is cytotoxic toward peripheral blood malignant cells from patients with adult T-cell leukemia

1 reference

https://api.crossref.org/works/10.1038%2FNBT1096-1239

7 January 2021

A bacterially expressed single-chain Fv construct from the 2B4 T-cell receptor.

1 reference

https://api.crossref.org/works/10.1038%2FNBT1096-1239

7 January 2021

Characterization of a single-chain T-cell receptor expressed in Escherichia coli

1 reference

https://api.crossref.org/works/10.1038%2FNBT1096-1239

7 January 2021

A soluble, single-chain T-cell receptor fragment endowed with antigen-combining properties

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https://api.crossref.org/works/10.1038%2FNBT1096-1239

7 January 2021

Secretion of T cell receptor fragments from recombinant Escherichia coli cells

1 reference

https://api.crossref.org/works/10.1038%2FNBT1096-1239

7 January 2021

A recombinant single-chain immunotoxin composed of anti-Tac variable regions and a truncated diphtheria toxin

1 reference

https://api.crossref.org/works/10.1038%2FNBT1096-1239

7 January 2021

Antitumor activity in mice of an immunotoxin made with anti-transferrin receptor and a recombinant form of Pseudomonas exotoxin

1 reference

https://api.crossref.org/works/10.1038%2FNBT1096-1239

7 January 2021

A recombinant immunotoxin that is active on prostate cancer cells and that is composed of the Fv region of monoclonal antibody PR1 and a truncated form of Pseudomonas exotoxin

1 reference

https://api.crossref.org/works/10.1038%2FNBT1096-1239

7 January 2021

Pseudomonas exotoxin contains a specific sequence at the carboxyl terminus that is required for cytotoxicity

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https://api.crossref.org/works/10.1038%2FNBT1096-1239

7 January 2021

Identifiers

DOI

10.1038/NBT1096-1239

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7 February 2018

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7 February 2018