Consensus Predictive Model for Human K562 Cell Growth Inhibition through Enalos Cloud Platform (Q47806909)

5 February 2018

title

Consensus Predictive Model for Human K562 Cell Growth Inhibition through Enalos Cloud Platform (English)

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5 February 2018

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5 February 2018

Georgia Melagraki

series ordinal

object named as

Georgia Melagraki

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5 February 2018

Georgios Leonis

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5 February 2018

author name string

Roberto Gambari

series ordinal

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5 February 2018

publication date

1 December 2017

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5 February 2018

published in

ChemMedChem

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5 February 2018

Updates of the HbVar database of human hemoglobin variants and thalassemia mutations

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7 January 2021

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7 January 2021

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7 January 2021

Medicinal chemistry of fetal hemoglobin inducers for treatment of beta-thalassemia

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7 January 2021

Pathophysiology of thalassaemia

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Phenotype-genotype relationships in monogenic disease: lessons from the thalassaemias.

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7 January 2021

Red blood cell transfusions for thalassemia: results of a survey assessing current practice and proposal of evidence-based guidelines

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7 January 2021

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7 January 2021

Recent trends for novel options in experimental biological therapy of β-thalassemia

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7 January 2021

Alternative options for DNA-based experimental therapy of β-thalassemia.

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7 January 2021

The emerging role of fetal hemoglobin induction in non-transfusion-dependent thalassemia

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7 January 2021

Fetal globin induction in beta-thalassemia

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7 January 2021

Targeted fetal hemoglobin induction for treatment of beta hemoglobinopathies

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7 January 2021

Pharmacologic Induction of Fetal Hemoglobin Production

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7 January 2021

Effects of rapamycin on accumulation of alpha-, beta- and gamma-globin mRNAs in erythroid precursor cells from beta-thalassaemia patients.

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7 January 2021

Human fetal globin gene expression is regulated by LYAR.

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7 January 2021

Reactivation of developmentally silenced globin genes by forced chromatin looping.

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7 January 2021

Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.

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7 January 2021

Developmental and species-divergent globin switching are driven by BCL11A

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7 January 2021

KLF1 regulates BCL11A expression and γ- to β-globin gene switching

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7 January 2021

cMYB is involved in the regulation of fetal hemoglobin production in adults.

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7 January 2021

Induction of endogenous gamma-globin gene expression with decoy oligonucleotide targeting Oct-1 transcription factor consensus sequence

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7 January 2021

Development and characterization of K562 cell clones expressing BCL11A-XL: Decreased hemoglobin production with fetal hemoglobin inducers and its rescue with mithramycin

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7 January 2021

Induction of adult levels of β-globin in human erythroid cells that intrinsically express embryonic or fetal globin by transduction with KLF1 and BCL11A-XL

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7 January 2021

Control of fetal hemoglobin: new insights emerging from genomics and clinical implications

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7 January 2021

Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing

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7 January 2021

Transcriptional regulators Myb and BCL11A interplay with DNA methyltransferase 1 in developmental silencing of embryonic and fetal β-like globin genes.

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

Induction of fetal hemoglobin expression by the histone deacetylase inhibitor apicidin

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

Induction of human fetal hemoglobin expression by adenosine-2',3'-dialdehyde.

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7 January 2021

Fetal Hemoglobin Inducers from the Natural World: A Novel Approach for Identification of Drugs for the Treatment of {beta}-Thalassemia and Sickle-Cell Anemia.

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7 January 2021

Identification of fetal hemoglobin-inducing agents using the human leukemia KU812 cell line

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

Design, synthesis and evaluation of (E)-alpha-benzylthio chalcones as novel inhibitors of BCR-ABL kinase

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

Synthesis and Antiproliferative Effect of Ethyl 4-[4-(4-Substituted Piperidin-1-yl)]benzylpyrrolo[1,2-a]quinoxalinecarboxylate Derivatives on Human Leukemia Cells.

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

Effects of Pimozide Derivatives on pSTAT5 in K562 Cells.

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

Design, Synthesis, and Evaluation of Dasatinib-Amino Acid and Dasatinib-Fatty Acid Conjugates as Protein Tyrosine Kinase Inhibitors.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

Regulation of the Erk2-Elk1 signaling pathway and megakaryocytic differentiation of Bcr-Abl(+) K562 leukemic cells by Gab2

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

C(5) modified uracil derivatives showing antiproliferative and erythroid differentiation inducing activities on human chronic myelogenous leukemia K562 cells.

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

K562 human leukaemic cells synthesise embryonic haemoglobin in response to haemin

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

Embryonic erythroid differentiation in the human leukemic cell line K562.

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

The therapeutic reactivation of fetal haemoglobin

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7 January 2021

Development of a Predictive Pharmacophore Model and a 3D-QSAR Study for an in silico Screening of New Potent Bcr-Abl Kinase Inhibitors

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

Ester of Quinoxaline-7-carboxylate 1,4-di-N-oxide as Apoptosis Inductors in K-562 Cell Line: An in vitro, QSAR and DFT Study.

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7 January 2021

Optimal management of β thalassaemia intermedia.

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7 January 2021

Augmentation by Erythropoietin of the Fetal-Hemoglobin Response to Hydroxyurea in Sickle Cell Disease

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

Desensitization to hydroxycarbamide following long-term treatment of thalassaemia intermedia as observed in vivo and in primary erythroid cultures from treated patients.

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7 January 2021

Thalidomide therapy in a patient with thalassemia major.

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7 January 2021

Butyrate increases the efficiency of translation of gamma-globin mRNA.

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7 January 2021

Administration of high doses of recombinant human erythropoietin to patients with beta-thalassemia intermedia: a preliminary trial

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7 January 2021

Darbepoetin alfa for the treatment of anaemia in alpha- or beta- thalassaemia intermedia syndromes

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7 January 2021

Cheminformatics-aided discovery of small-molecule Protein-Protein Interaction (PPI) dual inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL).

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

A Risk Assessment Tool for the Virtual Screening of Metal Oxide Nanoparticles through Enalos InSilicoNano Platform.

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

Mold(2), molecular descriptors from 2D structures for chemoinformatics and toxicoinformatics

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

Molecular Descriptors for Chemoinformatics

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

Handbook of Molecular Descriptors

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7 January 2021

Best Practices for QSAR Model Development, Validation, and Exploitation

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

A Novel QSAR Model for Evaluating and Predicting the Inhibition Activity of Dipeptidyl Aspartyl Fluoromethylketones

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

JSME: a free molecule editor in JavaScript

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

Editorial: Towards Open Access for Cheminformatics.

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

The perspectives of computational chemistry modeling

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

Enalos KNIME nodes: Exploring corrosion inhibition of steel in acidic medium

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

The application of new HARD-descriptor available from the CORAL software to building up NOAEL models.

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

The WEKA data mining software: an update

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

Identifying Important Risk Factors for Survival in Kidney Graft Failure Patients Using Random Survival Forests

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

Development of a robust and validated 2D-QSPR model for sweetness potency of diverse functional organic molecules

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

Ligand-based virtual screening procedure for the prediction and the identification of novel β-amyloid aggregation inhibitors using Kohonen maps and Counterpropagation Artificial Neural Networks.

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

Molecular modeling on pyrimidine-urea inhibitors of TNF-α production: an integrated approach using a combination of molecular docking, classification techniques, and 3D-QSAR CoMSIA.

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

The applications of machine learning algorithms in the modeling of estrogen-like chemicals

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

Development, Validation and Inspection of the Applicability Domain of QSPR Models for Physicochemical Properties of Polybrominated Diphenyl Ethers

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7 January 2021

A novel automated lazy learning QSAR (ALL-QSAR) approach: method development, applications, and virtual screening of chemical databases using validated ALL-QSAR models

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

Enalos InSilicoNano platform: an online decision support tool for the design and virtual screening of nanoparticles

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https://api.crossref.org/works/10.1002%2FCMDC.201700675

7 January 2021

Identifiers

DOI

10.1002/CMDC.201700675

1 reference

5 February 2018

release_fuucofbyd5b6rarhrbas6h7yc4

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/fuucofbyd5b6rarhrbas6h7yc4

24 November 2022

mapped directly with Wikidata item

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5 February 2018