Selectively N-methylated soluble IAPP mimics as potent IAPP receptor agonists and nanomolar inhibitors of cytotoxic self-assembly of both IAPP and Aβ40. (Q47752480)

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English	Selectively N-methylated soluble IAPP mimics as potent IAPP receptor agonists and nanomolar inhibitors of cytotoxic self-assembly of both IAPP and Aβ40.	scientific article

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5 February 2018

http://europepmc.org/abstract/MED/23956012

Selectively N-methylated soluble IAPP mimics as potent IAPP receptor agonists and nanomolar inhibitors of cytotoxic self-assembly of both IAPP and Aβ40. (English)

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5 February 2018

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Aphrodite Kapurniotu

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Aphrodite Kapurniotu

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Marianna Tatarek-Nossol

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Marianna Tatarek-Nossol

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Erika Andreetto

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Erika Andreetto

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Aleksandra Velkova

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Aleksandra Velkova

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Maria Bakou

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Michael Kracklauer

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Michael Kracklauer

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Eleni Malideli

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Gerhard Rammes

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Andrei Sibaev

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Burkhard Göke

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Jörg Schirra

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Martin Storr

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Li-Mei Yan

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publication date

19 August 2013

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Angewandte Chemie International Edition

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52

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39

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10378-10383

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Islet amyloid polypeptide, islet amyloid, and diabetes mellitus

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201302840

21 January 2018

Aspects on human amyloid forms and their fibril polypeptides

1 reference

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The role of amylin in the control of energy homeostasis

1 reference

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Implications of amylin receptor agonism: integrated neurohormonal mechanisms and therapeutic applications

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Adjunct therapy for type 1 diabetes mellitus

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https://api.crossref.org/works/10.1002%2FANIE.201302840

21 January 2018

Design of a mimic of nonamyloidogenic and bioactive human islet amyloid polypeptide (IAPP) as nanomolar affinity inhibitor of IAPP cytotoxic fibrillogenesis

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201302840

21 January 2018

Identification of a penta- and hexapeptide of islet amyloid polypeptide (IAPP) with amyloidogenic and cytotoxic properties

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201302840

21 January 2018

Identification of hot regions of the Abeta-IAPP interaction interface as high-affinity binding sites in both cross- and self-association

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201302840

21 January 2018

Diabetes mellitus and Alzheimer's disease: shared pathology and treatment?

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201302840

21 January 2018

Common pathological processes in Alzheimer disease and type 2 diabetes: a review

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https://api.crossref.org/works/10.1002%2FANIE.201302840

21 January 2018

The amyloid formation mechanism in human IAPP: dimers have β-strand monomer-monomer interfaces

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201302840

21 January 2018

Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201302840

21 January 2018

Peptide conformation and supramolecular organization in amylin fibrils: constraints from solid-state NMR.

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https://api.crossref.org/works/10.1002%2FANIE.201302840

21 January 2018

Gastric emptying in diabetes: clinical significance and treatment.

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21 January 2018

Amyloid β: linking synaptic plasticity failure to memory disruption in Alzheimer's disease

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21 January 2018

Alzheimer's disease: synaptic dysfunction and Abeta

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21 January 2018

Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation.

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Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice

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N-methylation of peptides: a new perspective in medicinal chemistry

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201302840

21 January 2018

Two-dimensional infrared spectroscopy reveals the complex behaviour of an amyloid fibril inhibitor

1 reference

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21 January 2018

Dissecting the role of single regions of an IAPP mimic and IAPP in inhibition of Aβ40 amyloid formation and cytotoxicity.

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201302840

21 January 2018

Inhibition of toxicity in the beta-amyloid peptide fragment beta -(25-35) using N-methylated derivatives: a general strategy to prevent amyloid formation

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201302840

21 January 2018

Peptide-based inhibitors of amyloid assembly

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201302840

21 January 2018

Inhibition of beta-amyloid(40) fibrillogenesis and disassembly of beta-amyloid(40) fibrils by short beta-amyloid congeners containing N-methyl amino acids at alternate residues

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201302840

21 January 2018

Identifiers

10.1002/ANIE.201302840

1 reference

Europe PubMed Central

PubMed publication ID

5 February 2018

http://europepmc.org/abstract/MED/23956012

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 February 2018

http://europepmc.org/abstract/MED/23956012

ResearchGate publication ID

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