HDL Cholesterol Metabolism and the Risk of CHD: New Insights from Human Genetics (Q47657807)

4 February 2018

title

HDL Cholesterol Metabolism and the Risk of CHD: New Insights from Human Genetics (English)

1 reference

4 February 2018

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Cecilia Vitali

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4 February 2018

Sumeet A Khetarpal

series ordinal

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4 February 2018

Daniel J Rader

series ordinal

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4 February 2018

publication date

4 November 2017

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4 February 2018

Current cardiology reports

published in

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4 February 2018

volume

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4 February 2018

issue

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4 February 2018

page(s)

132

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4 February 2018

Simple scoring scheme for calculating the risk of acute coronary events based on the 10-year follow-up of the prospective cardiovascular Münster (PROCAM) study

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Principal-component-based population structure adjustment in the North American Rheumatoid Arthritis Consortium data: impact of single-nucleotide polymorphism set and analysis method

21 January 2018

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Assessing the Power of Exome Chips

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Lecithin cholesterol acyltransferase

21 January 2018

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Lecithin:cholesterol acyltransferase: old friend or foe in atherosclerosis?

21 January 2018

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Lecithin: cholesterol acyltransferase expression has minimal effects on macrophage reverse cholesterol transport in vivo

21 January 2018

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LCAT modulates atherogenic plasma lipoproteins and the extent of atherosclerosis only in the presence of normal LDL receptors in transgenic rabbits

21 January 2018

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Lecithin:cholesterol acyltransferase overexpression generates hyperalpha-lipoproteinemia and a nonatherogenic lipoprotein pattern in transgenic rabbits

21 January 2018

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Adenoviral expression of human lecithin-cholesterol acyltransferase in nonhuman primates leads to an antiatherogenic lipoprotein phenotype by increasing high-density lipoprotein and lowering low-density lipoprotein

21 January 2018

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Analysis of glomerulosclerosis and atherosclerosis in lecithin cholesterol acyltransferase-deficient mice.

21 January 2018

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Lecithin:cholesterol acyltransferase deficiency increases atherosclerosis in the low density lipoprotein receptor and apolipoprotein E knockout mice

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Dose-Dependent Acceleration of High-Density Lipoprotein Catabolism by Endothelial Lipase

21 January 2018

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A novel endothelial-derived lipase that modulates HDL metabolism

21 January 2018

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Endothelial lipase is a major determinant of HDL level

21 January 2018

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Endothelial lipase promotes the catabolism of ApoB-containing lipoproteins

21 January 2018

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Hepatic SR-BI, not endothelial lipase, expression determines biliary cholesterol secretion in mice

21 January 2018

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Increased Hepatic Expression of Endothelial Lipase Inhibits Cholesterol Diet-Induced Hypercholesterolemia and Atherosclerosis in Transgenic Rabbits.

21 January 2018

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Impact of combined deficiency of hepatic lipase and endothelial lipase on the metabolism of both high-density lipoproteins and apolipoprotein B-containing lipoproteins

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Endothelial lipase modulates HDL but has no effect on atherosclerosis development in apoE-/- and LDLR-/- mice

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Endothelial lipase modulates susceptibility to atherosclerosis in apolipoprotein-E-deficient mice

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Lower plasma levels and accelerated clearance of high density lipoprotein (HDL) and non-HDL cholesterol in scavenger receptor class B type I transgenic mice

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Gene transfer and hepatic overexpression of the HDL receptor SR-BI reduces atherosclerosis in the cholesterol-fed LDL receptor-deficient mouse

21 January 2018

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Targeted mutation reveals a central role for SR-BI in hepatic selective uptake of high density lipoprotein cholesterol

21 January 2018

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A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism

21 January 2018

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Scavenger receptor class B type I mediates the selective uptake of high-density lipoprotein-associated cholesteryl ester by the liver in mice

21 January 2018

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Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein E-deficient mice

21 January 2018

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Increased atherosclerosis in ApoE and LDL receptor gene knock-out mice as a result of human cholesteryl ester transfer protein transgene expression.

21 January 2018

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Decreased early atherosclerotic lesions in hypertriglyceridemic mice expressing cholesteryl ester transfer protein transgene

21 January 2018

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Cholesteryl ester transfer protein (CETP) expression protects against diet induced atherosclerosis in SR-BI deficient mice

21 January 2018

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A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits

21 January 2018

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Cholesteryl ester transfer protein inhibitor (JTT-705) and the development of atherosclerosis in rabbits with severe hypercholesterolaemia

21 January 2018

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Deficiency of Cholesteryl Ester Transfer Protein Protects Against Atherosclerosis in Rabbits

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Discovery and refinement of loci associated with lipid levels

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Biological, clinical and population relevance of 95 loci for blood lipids

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Circulating cholesteryl ester transfer protein and coronary heart disease: mendelian randomization meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Association of cholesteryl ester transfer protein (CETP) gene polymorphism, high density lipoprotein cholesterol and risk of coronary artery disease: a meta-analysis using a Mendelian randomization approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Functional lecithin: cholesterol acyltransferase is not required for efficient atheroprotection in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

The molecular basis of lecithin:cholesterol acyltransferase deficiency syndromes: a comprehensive study of molecular and biochemical findings in 13 unrelated Italian families

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Functional LCAT is not required for macrophage cholesterol efflux to human serum

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Compromised LCAT function is associated with increased atherosclerosis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Cholesteryl ester transfer protein (CETP) deficiency and CETP inhibitors

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Plasma levels of lecithin:cholesterol acyltransferase and risk of future coronary artery disease in apparently healthy men and women: a prospective case-control analysis nested in the EPIC-Norfolk population study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

High prevalence of mutations in LCAT in patients with low HDL cholesterol levels in The Netherlands: identification and characterization of eight novel mutations

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Update on the Role of Endothelial Lipase in High-Density Lipoprotein Metabolism, Reverse Cholesterol Transport, and Atherosclerosis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Fatty acids liberated from high-density lipoprotein phospholipids by endothelial-derived lipase are incorporated into lipids in HepG2 cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Identification of genetic variants in endothelial lipase in persons with elevated high-density lipoprotein cholesterol

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Identification of four novel genes contributing to familial elevated plasma HDL cholesterol in humans

21 January 2018

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The Impact of Partial and Complete Loss-of-Function Mutations in Endothelial Lipase on High-Density Lipoprotein Levels and Functionality in Humans

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Segregation of LIPG, CETP, and GALNT2 mutations in Caucasian families with extremely high HDL cholesterol

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Mining the LIPG allelic spectrum reveals the contribution of rare and common regulatory variants to HDL cholesterol

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

The T111I mutation in the EL gene modulates the impact of dietary fat on the HDL profile in women.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

The T111I variant in the endothelial lipase gene and risk of coronary heart disease in three independent populations

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Physical inactivity interacts with an endothelial lipase polymorphism to modulate high density lipoprotein cholesterol in the GOLDN study

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Population-Based Resequencing of LIPG and ZNF202 Genes in Subjects with Extreme HDL Levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Lack of association between common genetic variation in endothelial lipase (LIPG) and the risk for CAD and DVT.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Common variants at 30 loci contribute to polygenic dyslipidemia

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease

21 January 2018

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Large-scale association analysis identifies new risk loci for coronary artery disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Identification of scavenger receptor SR-BI as a high density lipoprotein receptor

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

SR-BI as target in atherosclerosis and cardiovascular disease - A comprehensive appraisal of the cellular functions of SR-BI in physiology and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Hepatic scavenger receptor BI promotes rapid clearance of high density lipoprotein free cholesterol and its transport into bile

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Relationship between expression levels and atherogenesis in scavenger receptor class B, type I transgenics

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Differential effects of scavenger receptor BI deficiency on lipid metabolism in cells of the arterial wall and in the liver

21 January 2018

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Influence of the high density lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiology

21 January 2018

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Genetic variation at the scavenger receptor class B type I gene locus determines plasma lipoprotein concentrations and particle size and interacts with type 2 diabetes: the framingham study

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Population-based study of SR-BI genetic variation and lipid profile.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Impact of genetic variants in human scavenger receptor class B type I (SCARB1) on plasma lipid traits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Association of SCARB1 variants with subclinical atherosclerosis and incident cardiovascular disease: the multi-ethnic study of atherosclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Scavenger receptor class B type I polymorphisms and peripheral arterial disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Association of scavenger receptor class B type I polymorphisms with subclinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Association of the Lipoprotein Receptor SCARB1 Common Missense Variant rs4238001 with Incident Coronary Heart Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Common variants associated with plasma triglycerides and risk for coronary artery disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

The -629C>A polymorphism in the CETP gene does not explain the association of TaqIB polymorphism with risk and age of myocardial infarction in Icelandic men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Common variation in cholesteryl ester transfer protein: relationship of first major adverse cardiovascular events with the apolipoprotein B/apolipoprotein A-I ratio and the total cholesterol/high-density lipoprotein cholesterol ratio

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Delayed catabolism of high density lipoprotein apolipoproteins A-I and A-II in human cholesteryl ester transfer protein deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Increased high-density lipoprotein levels caused by a common cholesteryl-ester transfer protein gene mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Genetic cholesteryl ester transfer protein deficiency caused by two prevalent mutations as a major determinant of increased levels of high density lipoprotein cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Heterozygosity for a loss-of-function mutation in GALNT2 improves plasma triglyceride clearance in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Multiple Hepatic Regulatory Variants at the GALNT2 GWAS Locus Associated with High-Density Lipoprotein Cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Parental origin of sequence variants associated with complex diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Lifestyle determinants of high-density lipoprotein cholesterol: the National Heart, Lung, and Blood Institute Family Heart Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

HDL cholesterol efflux capacity and incident cardiovascular events

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Association of HDL cholesterol efflux capacity with incident coronary heart disease events: a prospective case-control study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

High-density lipoprotein cholesterol efflux capacity as a relevant predictor of atherosclerotic coronary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Paradoxical association of enhanced cholesterol efflux with increased incident cardiovascular risks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Effects of extended-release niacin with laropiprant in high-risk patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Extended-Release Niacin/Laropiprant Improves Overall Efficacy of Postprandial Reverse Cholesterol Transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Infusion of reconstituted high-density lipoprotein leads to acute changes in human atherosclerotic plaque.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Severe atherosclerosis in transgenic mice expressing simian cholesteryl ester transfer protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11886-017-0940-0

Genetic cholesteryl ester transfer protein deficiency is extremely frequent in the Omagari area of Japan. Marked hyperalphalipoproteinemia caused by CETP gene mutation is not associated with longevity

21 January 2018

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12 December 2020

Expression of cholesteryl ester transfer protein in mice promotes macrophage reverse cholesterol transport

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12 December 2020

The molecular pathology of lecithin:cholesterol acyltransferase (LCAT) deficiency syndromes

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12 December 2020

Characterization of the lipolytic activity of endothelial lipase

1 reference

12 December 2020

Overexpression of human lecithin:cholesterol acyltransferase in mice offers no protection against diet-induced atherosclerosis

1 reference

12 December 2020

Vaccine-induced antibodies inhibit CETP activity in vivo and reduce aortic lesions in a rabbit model of atherosclerosis

1 reference

12 December 2020

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12 December 2020

Lecithin: cholesterol acyltransferase (LCAT) deficiency and risk of vascular disease: 25 year follow-up

1 reference

12 December 2020

Genetic etiology of isolated low HDL syndrome: incidence and heterogeneity of efflux defects

1 reference

12 December 2020

Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans

1 reference

12 December 2020

RISK FACTORS IN CORONARY HEART DISEASE. AN EVALUATION OF SEVERAL SERUM LIPIDS AS PREDICTORS OF CORONARY HEART DISEASE; THE FRAMINGHAM STUDY

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12 December 2020

Genome-wide association studies: past, present and future

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12 December 2020

Liver-specific overexpression of scavenger receptor BI decreases levels of very low density lipoprotein ApoB, low density lipoprotein ApoB, and high density lipoprotein in transgenic mice

1 reference

12 December 2020

Genetics of lipid traits: Genome-wide approaches yield new biology and clues to causality in coronary artery disease

1 reference

12 December 2020

Carriers of lecithin cholesterol acyltransferase gene mutations have accelerated atherogenesis as assessed by carotid 3.0-T magnetic resonance imaging [corrected]

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12 December 2020

Mice overexpressing human lecithin: cholesterol acvltransferase are not protected against diet‐induced atherosclerosis

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12 December 2020

Effect of antisense oligonucleotides against cholesteryl ester transfer protein on the development of atherosclerosis in cholesterol-fed rabbits

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12 December 2020

Oxidative stress is markedly elevated in lecithin:cholesterol acyltransferase-deficient mice and is paradoxically reversed in the apolipoprotein E knockout background in association with a reduction in atherosclerosis

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12 December 2020

High plasma HDL concentrations associated with enhanced atherosclerosis in transgenic mice overexpressing lecithinchoesteryl acyltransferase

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12 December 2020

Increased risk of coronary artery disease in Caucasians with extremely low HDL cholesterol due to mutations in ABCA1, APOA1, and LCAT.

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12 December 2020

Association of polymorphisms at the SR-BI gene locus with plasma lipid levels and body mass index in a white population

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12 December 2020

Genetic variant of the scavenger receptor BI in humans

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12 December 2020

Evidence that endothelial lipase remodels high density lipoproteins without mediating the dissociation of apolipoprotein A-I

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12 December 2020

LCAT, HDL cholesterol and ischemic cardiovascular disease: a Mendelian randomization study of HDL cholesterol in 54,500 individuals

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12 December 2020

Increased LDL cholesterol and atherosclerosis in LDL receptor-deficient mice with attenuated expression of scavenger receptor B1

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12 December 2020

Decreased atherosclerosis in heterozygous low density lipoprotein receptor-deficient mice expressing the scavenger receptor BI transgene

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12 December 2020

Patients with low HDL-cholesterol caused by mutations in LCAT have increased arterial stiffness

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12 December 2020

Raising HDL-C can be achieved by both lifestyle changes and pharmacological means. Introduction

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12 December 2020

The not-so-simple HDL story: Is it time to revise the HDL cholesterol hypothesis?

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12 December 2020

Intravenous apoA-I/lecithin discs increase pre-beta-HDL concentration in tissue fluid and stimulate reverse cholesterol transport in humans

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12 December 2020

Deficiency of serum cholesteryl-ester transfer activity in patients with familial hyperalphalipoproteinaemia

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12 December 2020

10.1007/S11886-017-0940-0

Identifiers

DOI

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4 February 2018

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4 February 2018