Dysregulation of the Mitochondrial Unfolded Protein Response Induces Non-Apoptotic Dopaminergic Neurodegeneration in C. elegans Models of Parkinson's Disease. (Q47655102)

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scientific article published on 13 October 2017

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English	Dysregulation of the Mitochondrial Unfolded Protein Response Induces Non-Apoptotic Dopaminergic Neurodegeneration in C. elegans Models of Parkinson's Disease.	scientific article published on 13 October 2017

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7 April 2020

Dysregulation of the Mitochondrial Unfolded Protein Response Induces Non-Apoptotic Dopaminergic Neurodegeneration in C. elegans Models of Parkinson's Disease (English)

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7 April 2020

Caenorhabditis elegans

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Parkinson's disease

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based on heuristic

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based on heuristic

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apoptotic process

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based on heuristic

inferred from title

neurodegeneration

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based on heuristic

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Samuel P Stanley

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7 April 2020

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7 April 2020

Kim A. Caldwell

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Kim A Caldwell

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Bryan A Martinez

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Daniel A Petersen

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Anthony L Gaeta

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13 October 2017

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7 April 2020

Journal of Neuroscience

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7 April 2020

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7 April 2020

11085-11100

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7 April 2020

The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

1 reference

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16 June 2018

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease

1 reference

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16 June 2018

Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response

1 reference

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A bacterial metabolite induces glutathione-tractable proteostatic damage, proteasomal disturbances, and PINK1-dependent autophagy in C. elegans

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The unpredictability of prolonged activation of stress response pathways

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Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

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Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt).

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Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection

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Caenorhabditis elegans pathways that surveil and defend mitochondria

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Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans

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16 June 2018

Mitochondrial dysfunction, oxidative stress, and neurodegeneration elicited by a bacterial metabolite in a C. elegans Parkinson's model

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Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.

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Oxidative stress and mitochondrial protein quality control in aging

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16 June 2018

The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway

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16 June 2018

Surveillance-Activated Defenses Block the ROS–Induced Mitochondrial Unfolded Protein Response

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16 June 2018

Mitochondrial fission, fusion, and stress

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16 June 2018

Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways

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16 June 2018

Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation.

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16 June 2018

Functional analysis of VPS41-mediated neuroprotection in Caenorhabditis elegans and mammalian models of Parkinson's disease.

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16 June 2018

SnapShot: Mitochondrial quality control

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16 June 2018

Dysregulated LRRK2 Signaling in Response to Endoplasmic Reticulum Stress Leads to Dopaminergic Neuron Degeneration in C. elegans

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16 June 2018

Quality Control of Mitochondrial Proteostasis

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16 June 2018

Estrogen receptor mediates a distinct mitochondrial unfolded protein response

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16 June 2018

Mitochondrial protein quality control during biogenesis and aging

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16 June 2018

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

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16 June 2018

Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo

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16 June 2018

Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro

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16 June 2018

A pivotal role for PINK1 and autophagy in mitochondrial quality control: implications for Parkinson disease

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16 June 2018

The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans

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16 June 2018

Caenorhabditits elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth

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16 June 2018

Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain

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16 June 2018

Quality control of mitochondria: protection against neurodegeneration and ageing

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16 June 2018

Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model

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The economic impact of Parkinson's disease

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16 June 2018

Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response

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16 June 2018

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

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16 June 2018

Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans

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16 June 2018

The E46K mutation in alpha-synuclein increases amyloid fibril formation.

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Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein

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Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein

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alpha-synuclein promotes mitochondrial deficit and oxidative stress

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16 June 2018

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Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.

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12 December 2020

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10.1523/JNEUROSCI.1294-17.2017

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