Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms. (Q47557278)

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scientific article published on 23 January 2018

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English	Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms.	scientific article published on 23 January 2018

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scholarly article

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12 March 2020

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Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms (English)

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12 March 2020

biomedical investigative technique

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19 September 2019

human digestive system

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7 October 2019

circulatory system

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10 October 2019

integumentary system

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21 October 2019

6

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12 March 2020

Delilah F G Hendriks

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12 March 2020

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Chris S Pridgeon

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12 March 2020

Constanze Schlott

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12 March 2020

Min Wei Wong

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12 March 2020

Minne B Heringa

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12 March 2020

Tobias Heckel

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12 March 2020

Laurence Launay

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Vitalina Gryshkova

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Stefan Przyborski

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Rachel N Bearon

10

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12 March 2020

Emma L Wilkinson

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12 March 2020

Tahera Ansari

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12 March 2020

John Greenman

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Sue Gibbs

15

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12 March 2020

James Sidaway

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12 March 2020

Rowena L Sison-Young

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12 March 2020

Paul Walker

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12 March 2020

Mike J Cross

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12 March 2020

B Kevin Park

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12 March 2020

Chris E P Goldring

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12 March 2020

publication date

23 January 2018

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12 March 2020

number of pages

13

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based on heuristic

inferred from page(s)

Archives of Toxicology

6 references

29 June 2019

19 September 2019

7 October 2019

10 October 2019

21 October 2019

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92

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12 March 2020

2

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12 March 2020

557-569

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12 March 2020

copyright license

Creative Commons Attribution 4.0 International

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29 June 2019

Europe PubMed Central

19 September 2019

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7 October 2019

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21 October 2019

copyright status

0 references

Comparison of Liver Cell Models Using the Basel Phenotyping Cocktail

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Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates

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State of the art in non-animal approaches for skin sensitization testing: from individual test methods towards testing strategies

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22 May 2018

Editor's Highlight: Modeling Compound-Induced Fibrogenesis In Vitro Using Three-Dimensional Bioprinted Human Liver Tissues

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Bioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity In Vitro

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Cytotoxicity evaluation using cryopreserved primary human hepatocytes in various culture formats

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A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity

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Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

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Cardiac Non-myocyte Cells Show Enhanced Pharmacological Function Suggestive of Contractile Maturity in Stem Cell Derived Cardiomyocyte Microtissues

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Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity

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Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication

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Development of a Full-Thickness Human Skin Equivalent In Vitro Model Derived from TERT-Immortalized Keratinocytes and Fibroblasts

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MUTZ-3 derived Langerhans cells in human skin equivalents show differential migration and phenotypic plasticity after allergen or irritant exposure.

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Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

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Phenotypic profiling of structural cardiotoxins in vitro reveals dependency on multiple mechanisms of toxicity

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Assessment of compound hepatotoxicity using human plateable cryopreserved hepatocytes in a 1536-well-plate format

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How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?

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The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform

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The utility of the minipig as an animal model in regulatory toxicology

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Toxicity testing in the 21st century: a vision and a strategy

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Cardiac fibroblast: the renaissance cell

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Integrated risk assessment and predictive value to humans of non-clinical repolarization assays

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Balancing early market access to new drugs with the need for benefit/risk data: a mounting dilemma

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Microfluidic organs-on-chips

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Trial watch: phase II and phase III attrition rates 2011-2012.

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An epidermal equivalent assay for identification and ranking potency of contact sensitizers

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14 August 2018

A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity

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14 August 2018

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

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14 August 2018

The ECVAM International Validation Study on In Vitro Tests for Skin Corrosivity. 2. Results and Evaluation by the Management Team.

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Primary endothelial damage is the mechanism of cardiotoxicity of tubulin-binding drugs

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14 August 2018

Food for thought...on alternative methods for chemical safety testing

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818581

14 August 2018

In vitro evaluation of the angiostatic potential of drugs using an endothelialized tissue-engineered connective tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818581

14 August 2018

Two-dimensional multiarray formation of hepatocyte spheroids on a microfabricated PEG-brush surface

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818581

14 August 2018

The concept of multispecies testing in industrial toxicology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818581

14 August 2018

Characterization of a new tissue-engineered human skin equivalent with hair.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29362863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Information needed to conduct first-in-human oncology trials in the United States: a view from a former FDA medical reviewer

1 reference

https://pubmed.ncbi.nlm.nih.gov/29362863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analytical pharmacology: the impact of numbers on pharmacology

1 reference

https://pubmed.ncbi.nlm.nih.gov/29362863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The European Medicines Agency: an overview of its mission, responsibilities, and recent initiatives in cancer drug regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29362863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Can in vitro mammalian cell genotoxicity test results be used to complement positive results in the Ames test and help predict carcinogenic or in vivo genotoxic activity? II. Construction and analysis of a consolidated database

1 reference

https://pubmed.ncbi.nlm.nih.gov/29362863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterisation of porcine dermis scaffolds decellularised using a novel non-enzymatic method for biomedical applications

1 reference

https://pubmed.ncbi.nlm.nih.gov/29362863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lessons from the fatal French study BIA-10-2474

1 reference

https://pubmed.ncbi.nlm.nih.gov/29362863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00204-018-2152-9

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29362863%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29362863%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29362863%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

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