Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients. (Q47410087)

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8 April 2020

title

Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients (English)

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8 April 2020

main subject

arterial hypertension

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based on heuristic

inferred from title

author

Evangelos D Michelakis

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Aristeidis E Boukouris

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John Cupitt

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Vikram Gurtu

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Linda Webster

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Gareth Barnes

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Ian Paterson

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Kelvin Chow

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Adam Kinnaird

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Stephen J Wort

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8 April 2020

J Simon R Gibbs

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language of work or name

English

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publication date

1 October 2017

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Science Translational Medicine

8 April 2020

published in

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volume

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8 April 2020

issue

413

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Pulmonary arterial hypertension: challenges in translational research and a vision for change

8 April 2020

cites work

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A proposed mitochondrial-metabolic mechanism for initiation and maintenance of pulmonary arterial hypertension in fawn-hooded rats: the Warburg model of pulmonary arterial hypertension

21 January 2018

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An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension

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Tyr-301 phosphorylation inhibits pyruvate dehydrogenase by blocking substrate binding and promotes the Warburg effect.

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Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans

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Uncoupling protein 2 deficiency mimics the effects of hypoxia and endoplasmic reticulum stress on mitochondria and triggers pseudohypoxic pulmonary vascular remodeling and pulmonary hypertension.

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Genetic Variance in Uncoupling Protein 2 in Relation to Obesity, Type 2 Diabetes, and Related Metabolic Traits: Focus on the Functional -866G>A Promoter Variant (rs659366)

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A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans

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21 January 2018

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21 January 2018

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21 January 2018

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10.1126/SCITRANSLMED.AAO4583

21 January 2018

Identifiers

DOI

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8 April 2020

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