Blocking the Interaction between EphB2 and ADDLs by a Small Peptide Rescues Impaired Synaptic Plasticity and Memory Deficits in a Mouse Model of Alzheimer's Disease (Q47361357)

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scientific article published in November 2016

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English	Blocking the Interaction between EphB2 and ADDLs by a Small Peptide Rescues Impaired Synaptic Plasticity and Memory Deficits in a Mouse Model of Alzheimer's Disease	scientific article published in November 2016

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scholarly article

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Europe PubMed Central

PubMed publication ID

14 January 2018

http://europepmc.org/abstract/MED/27881781

Blocking the Interaction between EphB2 and ADDLs by a Small Peptide Rescues Impaired Synaptic Plasticity and Memory Deficits in a Mouse Model of Alzheimer's Disease (English)

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Europe PubMed Central

PubMed publication ID

14 January 2018

http://europepmc.org/abstract/MED/27881781

Alzheimer's disease

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synaptic plasticity

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based on heuristic

inferred from title

2

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15 May 2020

12

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15 May 2020

author name string

Xiao-Dong Shi

1

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15 May 2020

Rui Hu

3

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15 May 2020

Xiao-Ya Liu

4

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15 May 2020

Qiu-Mei Hu

5

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15 May 2020

Xiao-Yu Sun

6

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15 May 2020

Bin Yao

7

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15 May 2020

Nan Sun

8

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15 May 2020

Jing-Ru Hao

9

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15 May 2020

Pan Wei

10

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15 May 2020

Yuan Han

11

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15 May 2020

language of work or name

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publication date

1 November 2016

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14 January 2018

http://europepmc.org/abstract/MED/27881781

Journal of Neuroscience

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15 May 2020

36

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15 May 2020

47

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15 May 2020

11959-11973

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15 May 2020

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6604917/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Distribution of glutamate receptor subunit NMDAR1 in the hippocampus of normal elderly and patients with Alzheimer's disease.

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https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

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inferred from PubMed ID database lookup

EphB receptors interact with NMDA receptors and regulate excitatory synapse formation

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https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

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N-Methyl-D-aspartate receptor subunit proteins and their phosphorylation status are altered selectively in Alzheimer's disease

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https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-expression of multiple transgenes in mouse CNS: a comparison of strategies

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https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinase-independent requirement of EphB2 receptors in hippocampal synaptic plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The receptor tyrosine kinase EphB2 regulates NMDA-dependent synaptic function

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

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Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Src kinases: a hub for NMDA receptor regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

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Progressive cognitive impairment and anxiety induction in the absence of plaque deposition in C57BL/6 inbred mice expressing transgenic amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Receptor trafficking and synaptic plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

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Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of NMDA receptor trafficking by amyloid-beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vulnerability of dentate granule cells to disruption of arc expression in human amyloid precursor protein transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Common mechanisms of amyloid oligomer pathogenesis in degenerative disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

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A specific amyloid-beta protein assembly in the brain impairs memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of D1 dopamine receptors increases surface expression of AMPA receptors and facilitates their synaptic incorporation in cultured hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction between ephrins/Eph receptors and excitatory amino acid receptors: possible relevance in the regulation of synaptic plasticity and in the pathophysiology of neuronal degeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMDA and AMPA receptors: old channels, new tricks

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deregulation of NMDA-receptor function and down-stream signaling in APP[V717I] transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopamine alters AMPA receptor synaptic expression and subunit composition in dopamine neurons of the ventral tegmental area cultured with prefrontal cortex neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-specific blockade of RAGE-Vd prevents amyloid-beta oligomer neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retinoic acid attenuates beta-amyloid deposition and rescues memory deficits in an Alzheimer's disease transgenic mouse model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early changes in hippocampal Eph receptors precede the onset of memory decline in mouse models of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peptide EphB2/CTF2 generated by the gamma-secretase processing of EphB2 receptor promotes tyrosine phosphorylation and cell surface localization of N-methyl-D-aspartate receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The secretases: enzymes with therapeutic potential in Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: strategies for disease modification

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-Aβ Therapeutics in Alzheimer's Disease: The Need for a Paradigm Shift

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

What the halted phase III γ-secretase inhibitor trial may (or may not) be telling us.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EphB controls NMDA receptor function and synaptic targeting in a subunit-specific manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropsin cleaves EphB2 in the amygdala to control anxiety

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble Aβ Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IQGAP1 regulates NR2A signaling, spine density, and cognitive processes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ablation of cellular prion protein does not ameliorate abnormal neural network activity or cognitive dysfunction in the J20 line of human amyloid precursor protein transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanisms of fear learning and memory.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aβ toxicity in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer mechanisms and therapeutic strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EphBs: an integral link between synaptic function and synaptopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-beta peptide 1-42 causes microtubule deregulation through N-methyl-D-aspartate receptors in mature hippocampal cultures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cognitive and non-cognitive behaviors in the triple transgenic mouse model of Alzheimer's disease expressing mutated APP, PS1, and Mapt (3xTg-AD).

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The contextual brain: implications for fear conditioning, extinction and psychopathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effects of EphB2 on Aβ1-42 oligomer-induced neurotoxicity and synaptic NMDA receptor signaling in hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systems biology of synaptic plasticity: a review on N-methyl-D-aspartate receptor mediated biochemical pathways and related mathematical models.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Eph receptors: new players in Alzheimer's disease pathogenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

L-Stepholidine rescues memory deficit and synaptic plasticity in models of Alzheimer's disease via activating dopamine D1 receptor/PKA signaling pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/27881781

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.1327-16.2016

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6604917&resulttype=core&format=json

15 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6604917&resulttype=core&format=json

15 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6604917&resulttype=core&format=json

15 May 2020

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