Genetic deletion or pharmacological inhibition of soluble epoxide hydrolase reduces brain damage and attenuates neuroinflammation after intracerebral hemorrhage. (Q47360938)

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scientific article published on 25 November 2017

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English	Genetic deletion or pharmacological inhibition of soluble epoxide hydrolase reduces brain damage and attenuates neuroinflammation after intracerebral hemorrhage.	scientific article published on 25 November 2017

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4 April 2020

Genetic deletion or pharmacological inhibition of soluble epoxide hydrolase reduces brain damage and attenuates neuroinflammation after intracerebral hemorrhage (English)

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Soluble epoxide hydrolase

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Chun-Hu Wu

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Tai-Ho Hung

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Shin Wen

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Chao-Chang Lin

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Szu-Fu Chen

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25 November 2017

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Journal of Neuroinflammation

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Alternative activation-skewed microglia/macrophages promote hematoma resolution in experimental intracerebral hemorrhage.

1 reference

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Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress.

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Soluble Epoxide Hydrolase in Hydrocephalus, Cerebral Edema, and Vascular Inflammation After Subarachnoid Hemorrhage

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Genetic variation in soluble epoxide hydrolase: association with outcome after aneurysmal subarachnoid hemorrhage

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Soluble epoxide hydrolase activity regulates inflammatory responses and seizure generation in two mouse models of temporal lobe epilepsy

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Vascular disruption and blood-brain barrier dysfunction in intracerebral hemorrhage

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Fingolimod for the treatment of intracerebral hemorrhage: a 2-arm proof-of-concept study

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(-)-Epicatechin protects hemorrhagic brain via synergistic Nrf2 pathways

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Inflammation in intracerebral hemorrhage: from mechanisms to clinical translation

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Soluble epoxide hydrolase inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is neuroprotective in rat model of ischemic stroke.

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Inhibition of soluble epoxide hydrolase after cardiac arrest/cardiopulmonary resuscitation induces a neuroprotective phenotype in activated microglia and improves neuronal survival

1 reference

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Soluble epoxide hydrolase: gene structure, expression and deletion

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Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states

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Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage

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PDGFR-α inhibition preserves blood-brain barrier after intracerebral hemorrhage.

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Translational and transcriptional control of Sp1 against ischaemia through a hydrogen peroxide-activated internal ribosomal entry site pathway.

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12 December 2020

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10.1186/S12974-017-1005-4

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