A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models. (Q47348308)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29217578%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

title

A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models (English)

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6 April 2020

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6 April 2020

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6 April 2020

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6 April 2020

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6 April 2020

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6 April 2020

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6 April 2020

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6 April 2020

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6 April 2020

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6 April 2020

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6 April 2020

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6 April 2020

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6 April 2020

Philip Castonguay

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6 April 2020

Svetlana Andreeva

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6 April 2020

Frank Dubois

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6 April 2020

Sigrid C Hoffmann

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6 April 2020

Mónica S Montesinos

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6 April 2020

Astrid Weins

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6 April 2020

Michael R Garrett

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6 April 2020

language of work or name

English

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publication date

1 December 2017

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6 April 2020

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volume

358

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issue

6368

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6 April 2020

page(s)

1332-1336

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TRPC6 G757D Loss-of-Function Mutation Associates with FSGS.

6 April 2020

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1 reference

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Calcium, TRPC channels, and regulation of the actin cytoskeleton in podocytes: towards a future of targeted therapies

3 July 2018

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Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease

3 July 2018

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Dendrin ablation prolongs life span by delaying kidney failure.

3 July 2018

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Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5.

3 July 2018

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A potential role for mechanical forces in the detachment of podocytes and the progression of CKD.

3 July 2018

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Genetic testing for nephrotic syndrome and FSGS in the era of next-generation sequencing

3 July 2018

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The landscape of clinical trials in nephrology: a systematic review of Clinicaltrials.gov

3 July 2018

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Inhibition of the TRPC5 ion channel protects the kidney filter

3 July 2018

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Riluzole activates TRPC5 channels independently of PLC activity

3 July 2018

1 reference

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ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling

3 July 2018

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Chronic kidney disease: global dimension and perspectives

3 July 2018

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Age-dependent salt hypertension in Dahl rats: fifty years of research.

3 July 2018

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Focal segmental glomerulosclerosis

3 July 2018

1 reference

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Cell biology and pathology of podocytes

3 July 2018

1 reference

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Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis

3 July 2018

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Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels

3 July 2018

1 reference

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TRPC6 enhances angiotensin II-induced albuminuria

3 July 2018

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Antagonistic Regulation of Actin Dynamics and Cell Motility by TRPC5 and TRPC6 Channels

3 July 2018

1 reference

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Essential role for TRPC5 in amygdala function and fear-related behavior.

3 July 2018

1 reference

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Mechanisms of angiotensin II signaling on cytoskeleton of podocytes

3 July 2018

1 reference

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Adiponectin regulates albuminuria and podocyte function in mice

3 July 2018

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Subcellular targeting of oxidants during endothelial cell migration

3 July 2018

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Rapid vesicular translocation and insertion of TRP channels

3 July 2018

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Angiotensin II type 1 receptor overexpression in podocytes induces glomerulosclerosis in transgenic rats

3 July 2018

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Seven-transmembrane receptors

3 July 2018

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Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-/- mice

3 July 2018

1 reference

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Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol

3 July 2018

1 reference

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Dahl salt-susceptible and salt-resistant rats. A review

3 July 2018

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Synaptopodin Is a Coincidence Detector of Tyrosine versus Serine/Threonine Phosphorylation for the Modulation of Rho Protein Crosstalk in Podocytes.

3 July 2018

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A role for genetic susceptibility in sporadic focal segmental glomerulosclerosis

14 August 2018

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Time-Course Genetic Analysis of Albuminuria in Dahl Salt-Sensitive Rats on Low-Salt Diet

14 August 2018

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Data quality aware analysis of differential expression in RNA-seq with NOISeq R/Bioc package

14 August 2018

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Crossref

https://api.crossref.org/works/10.1126%2FSCIENCE.AAL4178

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

21 January 2018

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Crossref

https://api.crossref.org/works/10.1126%2FSCIENCE.AAL4178

Glomerular cell number in normal subjects and in type 1 diabetic patients

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29217578

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mechanism underlying the efficacy of combination therapy with losartan and hydrochlorothiazide in rats with salt-sensitive hypertension

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29217578

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCIENCE.AAL4178

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6 April 2020

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6 April 2020

PubMed publication ID

29217578

1 reference

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