Neurotoxicity and memory deficits induced by soluble low-molecular-weight amyloid-β1-42 oligomers are revealed in vivo by using a novel animal model. (Q47305370)

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scientific article published in June 2012

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English	Neurotoxicity and memory deficits induced by soluble low-molecular-weight amyloid-β1-42 oligomers are revealed in vivo by using a novel animal model.	scientific article published in June 2012

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scholarly article

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3 February 2020

Neurotoxicity and memory deficits induced by soluble low-molecular-weight amyloid-β1-42 oligomers are revealed in vivo by using a novel animal model (English)

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3 February 2020

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toxic encephalopathy

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6

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3 February 2020

8

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3 February 2020

author name string

Jonathan Brouillette

1

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3 February 2020

Raphaëlle Caillierez

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3 February 2020

Nadège Zommer

3

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3 February 2020

Claire Alves-Pires

4

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3 February 2020

Iryna Benilova

5

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3 February 2020

Bart De Strooper

7

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3 February 2020

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publication date

1 June 2012

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3 February 2020

number of pages

10

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Journal of Neuroscience

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3 February 2020

32

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3 February 2020

23

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3 February 2020

7852-7861

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3 February 2020

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

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Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

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Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum insulin-like growth factor I regulates brain amyloid-beta levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid regulation of presynaptic nicotinic receptors in rat hippocampus and neocortex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhaled anesthetic enhancement of amyloid-beta oligomerization and cytotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of NMDA receptor trafficking by amyloid-beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A specific amyloid-beta protein assembly in the brain impairs memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or beta-amyloid deposits.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Solution state characterization of amyloid beta-derived diffusible ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain and behavior changes in 12-month-old Tg2576 and nontransgenic mice exposed to anesthetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transthyretin: a key gene involved in the maintenance of memory capacities during aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin).

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Abeta toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transthyretin accelerates vascular Abeta deposition in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-beta peptide (Abeta) neurotoxicity is modulated by the rate of peptide aggregation: Abeta dimers and trimers correlate with neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Angiotensin II AT2 receptor oligomers mediate G-protein dysfunction in an animal model of Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The deficit in long-term potentiation induced by chronic administration of amyloid-β is attenuated by treatment of rats with a novel phospholipid-based drug formulation, VP025

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic degeneration in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-neurotoxicity relationships of amyloid beta-protein oligomers

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transthyretin as a potential CSF biomarker for Alzheimer's disease and dementia with Lewy bodies: effects of treatment with cholinesterase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible involvement of transthyretin in hippocampal beta-amyloid burden and learning behaviors in a mouse model of Alzheimer's disease (TgCRND8).

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanisms of neurodegeneration in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the Interaction of β-Amyloid with Transthyretin Monomers and Tetramers

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Mechanism of Memory Impairment Induced by A&#946; Chronic Administration Involves Imbalance between Cytokines and Neurotrophins in the Rat Hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Propofol Directly Increases Tau Phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A standardized and biocompatible preparation of aggregate-free amyloid beta peptide for biophysical and biological studies of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Visualization of co-localization in Aβ42-administered neuroblastoma cells reveals lysosome damage and autophagosome accumulation related to cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau phosphorylation and sevoflurane anesthesia: an association to postoperative cognitive impairment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transthyretin sequesters amyloid beta protein and prevents amyloid formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aβ Deposition Is Associated with Neuropil Changes, but not with Overt Neuronal Loss in the Human Amyloid Precursor Protein V717F (PDAPP) Transgenic Mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/22674261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.5901-11.2012

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3 February 2020

PMC publication ID

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Europe PubMed Central

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3 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

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3 February 2020

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