A mixed modality approach towards Xi reactivation for Rett syndrome and other X-linked disorders. (Q47250939)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29282321%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

title

A mixed modality approach towards Xi reactivation for Rett syndrome and other X-linked disorders (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29282321%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

0 references

Chen-Yu Wang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29282321%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

Chunyao Wei

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29282321%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

William Press

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29282321%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

Weiyuan Ma

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29282321%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

Raymond J Kelleher

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29282321%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

language of work or name

English

0 references

publication date

27 December 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29282321%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

8 April 2020

published in

1 reference

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8 April 2020

volume

115

1 reference

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8 April 2020

issue

1 reference

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8 April 2020

page(s)

E668-E675

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29282321%20AND%20SRC:MED&resulttype=core&format=json

A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation

8 April 2020

cites work

1 reference

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Screen for reactivation of MeCP2 on the inactive X chromosome identifies the BMP/TGF-β superfamily as a regulator of XIST expression.

26 August 2018

1 reference

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TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes

26 August 2018

1 reference

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Female mice lacking Xist RNA show partial dosage compensation and survive to term

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789928

Non-coding RNAs as drug targets

26 August 2018

1 reference

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Unusual maintenance of X chromosome inactivation predisposes female lymphocytes for increased expression from the inactive X

26 August 2018

1 reference

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Rett Syndrome: Crossing the Threshold to Clinical Translation

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789928

Fitting the Puzzle Pieces: the Bigger Picture of XCI.

26 August 2018

1 reference

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A high-throughput screen of inactive X chromosome reactivation identifies the enhancement of DNA demethylation by 5-aza-2'-dC upon inhibition of ribonucleotide reductase

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789928

Chromosomes. A comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789928

Rett syndrome: a complex disorder with simple roots

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789928

Genetic and pharmacological reactivation of the mammalian inactive X chromosome.

26 August 2018

1 reference

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Behavioral phenotyping of Nestin-Cre mice: implications for genetic mouse models of psychiatric disorders

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789928

An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789928

Xist RNA is a potent suppressor of hematologic cancer in mice

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789928

Pharmacokinetic and pharmacodynamic analysis of 5-aza-2'-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapy.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789928

Preclinical research in Rett syndrome: setting the foundation for translational success.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789928

Antisense oligonucleotide therapeutics for inherited neurodegenerative diseases

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789928

Dosage compensation of the sex chromosomes

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789928

Spreading of X chromosome inactivation via a hierarchy of defined Polycomb stations

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789928

Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789928

X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789928

Gracefully ageing at 50, X-chromosome inactivation becomes a paradigm for RNA and chromatin control

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789928

Diverse factors are involved in maintaining X chromosome inactivation

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789928

Antidepressant-like effect induced by systemic and intra-hippocampal administration of DNA methylation inhibitors.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789928

Architectural epigenetics: mitotic retention of mammalian transcriptional regulatory information

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789928

Nestin-Cre mice are affected by hypopituitarism, which is not due to significant activity of the transgene in the pituitary gland.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789928

RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789928

MeCP2 functions largely cell-autonomously, but also non-cell-autonomously, in neuronal maturation and dendritic arborization of cortical pyramidal neurons

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789928

Reversal of neurological defects in a mouse model of Rett syndrome

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789928

Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789928

Synergism of Xist RNA, DNA methylation, and histone hypoacetylation in maintaining X chromosome inactivation

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789928

Potent and nontoxic antisense oligonucleotides containing locked nucleic acids

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789928

Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789928

Pilot phase I-II study on 5-aza-2'-deoxycytidine (Decitabine) in patients with metastatic lung cancer

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5789928

Plasma and cerebrospinal fluid pharmacokinetics of 5-Aza-2'-deoxycytidine in rabbits and dogs

26 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29282321

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Xist-deficient mice are defective in dosage compensation but not spermatogenesis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29282321

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1715124115

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29282321%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29282321%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

PubMed publication ID

29282321

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29282321%20AND%20SRC:MED&resulttype=core&format=json