The Aβ40 and Aβ42 peptides self-assemble into separate homomolecular fibrils in binary mixtures but cross-react during primary nucleation. (Q47110086)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29218188%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

title

The Aβ40 and Aβ42 peptides self-assemble into separate homomolecular fibrils in binary mixtures but cross-react during primary nucleation (English)

1 reference

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6 April 2020

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6 April 2020

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6 April 2020

1 reference

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6 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29218188%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

Katja Bernfur

1 reference

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6 April 2020

Birgitta Frohm

1 reference

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6 April 2020

Risto Cukalevski

1 reference

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6 April 2020

Xiaoting Yang

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6 April 2020

publication date

8 May 2015

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6 April 2020

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6 April 2020

volume

1 reference

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6 April 2020

issue

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6 April 2020

page(s)

4215-4233

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Aβ(1-42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

6 April 2020

cites work

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Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides

23 May 2018

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Assessing the causes and consequences of co-polymerization in amyloid formation

23 May 2018

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Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism

23 May 2018

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Alzheimer's Aβ42 and Aβ40 peptides form interlaced amyloid fibrils

23 May 2018

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Molecular structures of amyloid and prion fibrils: consensus versus controversy

23 May 2018

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Role of aromatic side chains in amyloid β-protein aggregation

23 May 2018

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23 May 2018

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Dual effect of amino modified polystyrene nanoparticles on amyloid β protein fibrillation

23 May 2018

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Amyloid β-protein aggregation produces highly reproducible kinetic data and occurs by a two-phase process

23 May 2018

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Cross-seeding effects of amyloid β-protein and α-synuclein

23 May 2018

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The amyloid state of proteins in human diseases

23 May 2018

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From macroscopic measurements to microscopic mechanisms of protein aggregation

23 May 2018

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Structural basis for increased toxicity of pathological aβ42:aβ40 ratios in Alzheimer disease

23 May 2018

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Molecular basis for amyloid- polymorphism

23 May 2018

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Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations

23 May 2018

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Interaction between amyloid beta peptide and an aggregation blocker peptide mimicking islet amyloid polypeptide

23 May 2018

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Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species

23 May 2018

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The role of protein sequence and amino acid composition in amyloid formation: scrambling and backward reading of IAPP amyloid fibrils

23 May 2018

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Molecular mechanism of Thioflavin-T binding to amyloid fibrils

23 May 2018

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Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process

23 May 2018

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Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils

23 May 2018

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Identifying the amylome, proteins capable of forming amyloid-like fibrils

23 May 2018

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The recombinant amyloid-beta peptide Abeta1-42 aggregates faster and is more neurotoxic than synthetic Abeta1-42.

23 May 2018

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The chemistry of Alzheimer's disease

23 May 2018

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A facile method for expression and purification of the Alzheimer's disease-associated amyloid beta-peptide

23 May 2018

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Molecular structural basis for polymorphism in Alzheimer's -amyloid fibrils

23 May 2018

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The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity

23 May 2018

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Atomic structures of amyloid cross-beta spines reveal varied steric zippers

23 May 2018

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A beta oligomers - a decade of discovery

23 May 2018

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A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

23 May 2018

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23 May 2018

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Protein misfolding, functional amyloid, and human disease

23 May 2018

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Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils

23 May 2018

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Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis.

23 May 2018

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Deciphering the molecular basis of memory failure in Alzheimer's disease

23 May 2018

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Observation of sequence specificity in the seeding of protein amyloid fibrils.

23 May 2018

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A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR

23 May 2018

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

23 May 2018

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Translating cell biology into therapeutic advances in Alzheimer's disease

23 May 2018

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NMRPipe: a multidimensional spectral processing system based on UNIX pipes

23 May 2018

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The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

23 May 2018

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Amyloid-beta aggregation: selective inhibition of aggregation in mixtures of amyloid with different chain lengths

23 May 2018

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Kinetics of sickle hemoglobin polymerization. II. A double nucleation mechanism.

23 May 2018

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Fluorometric determination of amyloid fibrils in vitro using the fluorescent dye, thioflavin T1.

23 May 2018

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Surface effects on aggregation kinetics of amyloidogenic peptides.

23 May 2018

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Exogenous amyloidogenic proteins function as seeds in amyloid β-protein aggregation.

15 August 2018

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Quantification of the concentration of Aβ42 propagons during the lag phase by an amyloid chain reaction assay.

15 August 2018

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A new structural model of Aβ40 fibrils.

15 August 2018

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Monte Carlo simulations of protein amyloid formation reveal origin of sigmoidal aggregation kinetics

15 August 2018

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Molecular basis for transmission barrier and interference between closely related prion proteins in yeast

15 August 2018

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Amyloid-beta peptide (Abeta) neurotoxicity is modulated by the rate of peptide aggregation: Abeta dimers and trimers correlate with neurotoxicity

15 August 2018

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Nucleation-dependent polymerization is an essential component of amyloid-mediated neuronal cell death.

15 August 2018

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Structural and dynamic features of Alzheimer's Abeta peptide in amyloid fibrils studied by site-directed spin labeling.

15 August 2018

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The origins of Alzheimer disease: a is for amyloid.

15 August 2018

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Interaction between A beta(1-42) and A beta(1-40) in Alzheimer's beta-amyloid fibril formation in vitro.

15 August 2018

1 reference

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Morphology and toxicity of Abeta-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease

15 August 2018

1 reference

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Global Optimization by Basin-Hopping and the Lowest Energy Structures of Lennard-Jones Clusters Containing up to 110 Atoms

15 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1039%2FC4SC02517B

Thioflavine T interaction with amyloid β-sheet structures

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1039%2FC4SC02517B

Single particle detection and characterization of synuclein co-aggregation

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29218188

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Abeta40 protects non-toxic Abeta42 monomer from aggregation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29218188

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1039/C4SC02517B

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29218188%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29218188%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

PubMed publication ID

29218188

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29218188%20AND%20SRC:MED&resulttype=core&format=json