Increased nicotinamide nucleotide transhydrogenase levels predispose to insulin hypersecretion in a mouse strain susceptible to diabetes. (Q46961703)

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8 January 2020

title

Increased nicotinamide nucleotide transhydrogenase levels predispose to insulin hypersecretion in a mouse strain susceptible to diabetes (English)

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8 January 2020

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8 January 2020

Kathryn Aston-Mourney

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8 January 2020

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8 January 2020

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8 January 2020

N Wong

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8 January 2020

S Zraika

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8 January 2020

B C Fam

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8 January 2020

J Favaloro

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8 January 2020

J Proietto

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8 January 2020

G Morahan

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8 January 2020

S Andrikopoulos

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8 January 2020

publication date

6 October 2007

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8 January 2020

number of pages

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published in

Diabetologia

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8 January 2020

volume

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issue

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8 January 2020

page(s)

2476-2485

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Understanding the pathogenesis of type 2 diabetes: can we get off the metabolic merry-go-rounds?

8 January 2020

cites work

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Isolation of highly purified mitochondria from rat pancreas

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12 December 2020

Molecular biology of nicotinamide nucleotide transhydrogenase — a unique proton pump

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A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2.

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Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance

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Genetic background (C57BL/6J versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice.

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The influence of genetic background on the induction of oxidative stress and impaired insulin secretion in mouse islets.

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12 December 2020

Limits on fine mapping of complex traits

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Adiponectin receptor 1 gene (ADIPOR1) as a candidate for type 2 diabetes and insulin resistance

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A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice

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12 December 2020

A genetic map of the mouse suitable for typing intraspecific crosses

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Prevalence of diabetes and impaired glucose tolerance in the biracial (Melanesian and Indian) population of Fiji: a rural-urban comparison

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12 December 2020

A quantitative trait locus influencing fasting plasma glucose in chromosome region 18q22-23.

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12 December 2020

Glucose homeostasis and tissue transcript content of insulin signaling intermediates in four inbred strains of mice: C57BL/6, C57BLKS/6, DBA/2, and 129X1.

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Identification of candidate disease genes by EST alignments, synteny, and expression and verification of Ensembl genes on rat chromosome 1q43-54.

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Genetic analysis of glucose tolerance in inbred mouse strains. Evidence for polygenic control.

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12 December 2020

Deletion of Nicotinamide Nucleotide Transhydrogenase: A New Quantitive Trait Locus Accounting for Glucose Intolerance in C57BL/6J Mice

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12 December 2020

High glucose-induced impairment in insulin secretion is associated with reduction in islet glucokinase in a mouse model of susceptibility to islet dysfunction

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12 December 2020

Variant in sulfonylurea receptor-1 gene is associated with high insulin concentrations in non-diabetic Mexican Americans: SUR-1 gene variant and hyperinsulinemia.

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Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children.

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Adiponectin gene polymorphism (G276T) is not associated with incipient diabetic nephropathy in Japanese type 2 diabetic patients

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12 December 2020

Coupling of beta-cell desensitization by hyperglycemia to excessive stimulation and circulating insulin in glucose-infused rats

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12 December 2020

Differential effect of inbred mouse strain (C57BL/6, DBA/2, 129T2) on insulin secretory function in response to a high fat diet

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12 December 2020

Familial hyperinsulinism caused by an activating glucokinase mutation

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12 December 2020

Vitamin D binding protein gene and genetic susceptibility to type 2 diabetes mellitus in a Polish population

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12 December 2020

Diabetes in identical twins. A study of 200 pairs

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12 December 2020

Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1.

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12 December 2020

Insulin resistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR).

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12 December 2020

Quantitative trait loci near the insulin-degrading enzyme (IDE) gene contribute to variation in plasma insulin levels

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12 December 2020

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12 December 2020

Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet

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12 December 2020

Evolution of insulin resistance in New Zealand obese mice.

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12 December 2020

A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia.

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12 December 2020

Elevated SNAP-25 is associated with fatty acid-induced impairment of mouse islet function

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12 December 2020

The influence of genetic background on the expression of mutations at the diabetes locus in the mouse. III. Effect of H-2 haplotype and sex.

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Does the aspartic acid to asparagine substitution at position 76 in the pancreas duodenum homeobox gene (PDX1) cause late-onset type 2 diabetes?

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Endothelial nitric oxide synthase gene is associated with diabetic macular edema in type 2 diabetes.

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12 December 2020

Genetic variation in BEACON influences quantitative variation in metabolic syndrome-related phenotypes

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12 December 2020

A QTL genome scan of the metabolic syndrome and its component traits

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12 December 2020

28 Assay of nicotinamide nucleotide transhydrogenases in mammalian, bacterial, and reconstituted systems

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12 December 2020

Large-scale studies of the functional K variant of the butyrylcholinesterase gene in relation to Type 2 diabetes and insulin secretion

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12 December 2020

Genetic background determines the size and structure of the endocrine pancreas

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12 December 2020

The hexosamine biosynthesis pathway regulates insulin secretion via protein glycosylation in mouse islets

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12 December 2020

Comparison of insulin secretory function in two mouse models with different susceptibility to beta-cell failure

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12 December 2020

Leptin-deficient mice backcrossed to the BALB/cJ genetic background have reduced adiposity, enhanced fertility, normal body temperature, and severe diabetes

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12 December 2020