Distinguishing aggrecan loss from aggrecan proteolysis in ADAMTS-4 and ADAMTS-5 single and double deficient mice. (Q46949433)

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8 January 2020

title

Distinguishing aggrecan loss from aggrecan proteolysis in ADAMTS-4 and ADAMTS-5 single and double deficient mice (English)

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8 January 2020

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8 January 2020

Mirna Z Ilic

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8 January 2020

Charlotte J East

series ordinal

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8 January 2020

Fraser M Rogerson

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8 January 2020

Christopher J Handley

series ordinal

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8 January 2020

language of work or name

English

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publication date

15 October 2007

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Journal of Biological Chemistry

8 January 2020

published in

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8 January 2020

volume

282

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8 January 2020

issue

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8 January 2020

page(s)

37420-37428

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Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family

8 January 2020

cites work

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Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins

21 January 2018

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Mechanism of catabolism of aggrecan by articular cartilage

21 January 2018

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Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

21 January 2018

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Cytokine induced metalloproteinase expression and activity does not correlate with focal susceptibility of articular cartilage to degeneration.

21 January 2018

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Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage

21 January 2018

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Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage

21 January 2018

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ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

21 January 2018

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Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4).

21 January 2018

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ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage

21 January 2018

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ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan

21 January 2018

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Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1

21 January 2018

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Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18

21 January 2018

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Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing

21 January 2018

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Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4)

21 January 2018

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Expression and activity of ADAMTS-5 in synovium

21 January 2018

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Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters.

21 January 2018

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Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.

21 January 2018

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Variations in aggrecan structure modulate its susceptibility to aggrecanases

21 January 2018

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ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan.

21 January 2018

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Catabolism of aggrecan by explant cultures of human articular cartilage in the presence of retinoic acid

21 January 2018

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The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain

21 January 2018

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Autocatalytic cleavage of ADAMTS-4 (Aggrecanase-1) reveals multiple glycosaminoglycan-binding sites

21 January 2018

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ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate

21 January 2018

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Activation of the proteolytic activity of ADAMTS4 (aggrecanase-1) by C-terminal truncation

21 January 2018

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Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network

21 January 2018

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Effects of covalently attached chondroitin sulfate on aggrecan cleavage by ADAMTS-4 and MMP-13.

21 January 2018

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The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage

21 January 2018

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N-linked keratan sulfate in the aggrecan interglobular domain potentiates aggrecanase activity.

21 January 2018

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Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice

21 January 2018

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Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5.

21 January 2018

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Complete coding sequence, deduced primary structure, chromosomal localization, and structural analysis of murine aggrecan

21 January 2018

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Characterization of aggrecan retained and lost from the extracellular matrix of articular cartilage. Involvement of carboxyl-terminal processing in the catabolism of aggrecan

21 January 2018

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Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing i

21 January 2018

1 reference

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N-terminal sequence of proteoglycan fragments isolated from medium of interleukin-1-treated articular-cartilage cultures. Putative site(s) of enzymic cleavage

21 January 2018

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ADAMTS-4 (aggrecanase-1): N-terminal activation mechanisms

21 January 2018

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Hyaluronate degradation as an alternative mechanism for proteoglycan release from cartilage during interleukin-1beta-stimulated catabolism

21 January 2018

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Acquisition of hyaluronate-binding affinity in vivo by newly synthesized cartilage proteoglycans

21 January 2018

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Complexes of matrilin-1 and biglycan or decorin connect collagen VI microfibrils to both collagen II and aggrecan

21 January 2018

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Mapping by monoclonal antibody detection of glycosaminoglycans in connective tissues

21 January 2018

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