Targeting MEK is effective chemoprevention of hepatocellular carcinoma in TGF-alpha-transgenic mice (Q46911481)

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scientific article published on 7 November 2007

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English	Targeting MEK is effective chemoprevention of hepatocellular carcinoma in TGF-alpha-transgenic mice	scientific article published on 7 November 2007

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instance of

scholarly article

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stated in

Europe PubMed Central

PubMed publication ID

17987349

retrieved

26 December 2017

reference URL

http://europepmc.org/abstract/MED/17987349

title

Targeting MEK is effective chemoprevention of hepatocellular carcinoma in TGF-alpha-transgenic mice (English)

1 reference

stated in

Europe PubMed Central

PubMed publication ID

17987349

retrieved

26 December 2017

reference URL

http://europepmc.org/abstract/MED/17987349

main subject

hepatocellular carcinoma

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inferred from title

author

Michele T. Yip-Schneider

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3

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Europe PubMed Central

PubMed publication ID

17987349

retrieved

26 December 2017

reference URL

http://europepmc.org/abstract/MED/17987349

author name string

Sabrina C Wentz

series ordinal

1

1 reference

stated in

Europe PubMed Central

PubMed publication ID

17987349

retrieved

26 December 2017

reference URL

http://europepmc.org/abstract/MED/17987349

Huangbing Wu

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2

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Europe PubMed Central

PubMed publication ID

17987349

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26 December 2017

reference URL

http://europepmc.org/abstract/MED/17987349

Matthew Hennig

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4

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Europe PubMed Central

PubMed publication ID

17987349

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26 December 2017

reference URL

http://europepmc.org/abstract/MED/17987349

Patrick J Klein

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5

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Europe PubMed Central

PubMed publication ID

17987349

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26 December 2017

reference URL

http://europepmc.org/abstract/MED/17987349

Judith Sebolt-Leopold

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6

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Europe PubMed Central

PubMed publication ID

17987349

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26 December 2017

reference URL

http://europepmc.org/abstract/MED/17987349

C Max Schmidt

series ordinal

7

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stated in

Europe PubMed Central

PubMed publication ID

17987349

retrieved

26 December 2017

reference URL

http://europepmc.org/abstract/MED/17987349

publication date

7 November 2007

1 reference

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Europe PubMed Central

PubMed publication ID

17987349

retrieved

26 December 2017

reference URL

http://europepmc.org/abstract/MED/17987349

number of pages

8

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published in

Journal of Gastrointestinal Surgery

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Europe PubMed Central

PubMed publication ID

17987349

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26 December 2017

reference URL

http://europepmc.org/abstract/MED/17987349

volume

12

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Europe PubMed Central

PubMed publication ID

17987349

retrieved

26 December 2017

reference URL

http://europepmc.org/abstract/MED/17987349

issue

1

1 reference

stated in

Europe PubMed Central

PubMed publication ID

17987349

retrieved

26 December 2017

reference URL

http://europepmc.org/abstract/MED/17987349

page(s)

30-37

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Europe PubMed Central

PubMed publication ID

17987349

retrieved

26 December 2017

reference URL

http://europepmc.org/abstract/MED/17987349

cites work

Transforming growth factor alpha dramatically enhances oncogene-induced carcinogenesis in transgenic mouse pancreas and liver

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reference URL

https://api.crossref.org/works/10.1007%2FS11605-007-0396-4

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21 January 2018

Rapid development of hepatic tumors in transforming growth factor alpha transgenic mice associated with increased cell proliferation in precancerous hepatocellular lesions initiated by N-nitrosodiethylamine and promoted by phenobarbital

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17987349

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12 December 2020

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Use of tamoxifen in advanced-stage hepatocellular carcinoma. A systematic review.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17987349

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12 December 2020

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Human hepatic preneoplasia: phenotypes and proliferation kinetics of foci and nodules of altered hepatocytes and their relationship to liver cell dysplasia

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17987349

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12 December 2020

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Down-regulation of c-Myc following MEK/ERK inhibition halts the expression of malignant phenotype in rhabdomyosarcoma and in non muscle-derived human tumors.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17987349

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12 December 2020

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Chemoprevention of spontaneous development of hepatocellular carcinomas in fatty liver Shionogi mice by a cyclooxygenase-2 inhibitor.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17987349

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12 December 2020

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Prevention of rat hepatocarcinogenesis by acyclic retinoid is accompanied by reduction in emergence of both TGF-alpha-expressing oval-like cells and activated hepatic stellate cells

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17987349

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12 December 2020

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Prevention of hepatocellular carcinoma

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17987349

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12 December 2020

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Prometheus' challenge: molecular, cellular and systemic aspects of liver regeneration.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17987349

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12 December 2020

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Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17987349

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12 December 2020

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Increased MAPK expression and activity in primary human hepatocellular carcinoma

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17987349

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12 December 2020

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inferred from PubMed ID database lookup

Primary liver cancer: worldwide incidence and trends

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17987349

retrieved

12 December 2020

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BRAF mutation predicts sensitivity to MEK inhibition

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17987349

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12 December 2020

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Pharmacodynamic and toxicokinetic evaluation of the novel MEK inhibitor, PD0325901, in the rat following oral and intravenous administration

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17987349

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12 December 2020

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Synergy between transforming growth factor alpha and hepatitis B virus surface antigen in hepatocellular proliferation and carcinogenesis.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17987349

retrieved

12 December 2020

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Molecular mechanisms of hepatocarcinogenesis in transgenic mouse models of liver cancer

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17987349

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12 December 2020

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inferred from PubMed ID database lookup

Development of liver tumors in transforming growth factor alpha transgenic mice.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17987349

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12 December 2020

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inferred from PubMed ID database lookup

Disruption of beta-catenin pathway or genomic instability define two distinct categories of liver cancer in transgenic mice

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17987349

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12 December 2020

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A morphologic classification of proliferative and neoplastic hepatic lesions in mice

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17987349

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12 December 2020

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Chemoprevention of hepatocellular carcinoma: use of tamoxifen in an animal model of hepatocarcinogenesis

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17987349

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12 December 2020

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Targeting the mitogen-activated protein kinase cascade to treat cancer

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17987349

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12 December 2020

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Hepatocellular carcinoma

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17987349

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12 December 2020

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Interferon therapy as chemoprevention of hepatocarcinogenesis in patients with chronic hepatitis C.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17987349

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12 December 2020

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Hepatitis C virus core protein promotes proliferation of human hepatoma cells through enhancement of transforming growth factor expression via activation of nuclear factor- B

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17987349

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12 December 2020

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Hepatocellular carcinoma

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17987349

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12 December 2020

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Proliferating cell nuclear antigen and Ki-67 labeling in hepatocellular nodules: a comparative study

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17987349

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tamoxifen is not effective in good prognosis patients with hepatocellular carcinoma.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17987349

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Significance of sequential cellular changes inside and outside foci of altered hepatocytes during hepatocarcinogenesis

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17987349

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatocellular carcinoma

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17987349

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12 December 2020

based on heuristic

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Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17987349

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12 December 2020

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Hepatitis B virus infection: epidemiology and vaccination

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17987349

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12 December 2020

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inferred from PubMed ID database lookup

Significance of hepatic preneoplasia for cancer chemoprevention

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17987349

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12 December 2020

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inferred from PubMed ID database lookup

Prevention of hepatocellular carcinoma recurrence with alpha-interferon after liver resection in HCV cirrhosis

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17987349

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12 December 2020

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Significance of hepatic preneoplasia in risk identification and early detection of neoplasia

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17987349

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12 December 2020

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Identifiers

DOI

10.1007/S11605-007-0396-4

1 reference

stated in

Europe PubMed Central

PubMed publication ID

17987349

retrieved

26 December 2017

reference URL

http://europepmc.org/abstract/MED/17987349

PubMed publication ID

17987349

1 reference

stated in

Europe PubMed Central

PubMed publication ID

17987349

retrieved

26 December 2017

reference URL

http://europepmc.org/abstract/MED/17987349

 

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