Biophysical and biochemical investigations of dsRNA-activated kinase PKR. (Q46905275)

26 December 2017

title

Biophysical and biochemical investigations of dsRNA-activated kinase PKR. (English)

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26 December 2017

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26 December 2017

author name string

Darrin A Lindhout

series ordinal

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26 December 2017

Takashi Shimoike

series ordinal

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26 December 2017

Joseph D Puglisi

series ordinal

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26 December 2017

language of work or name

English

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publication date

1 January 2007

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26 December 2017

published in

Methods in Enzymology

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26 December 2017

volume

430

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26 December 2017

page(s)

373-396

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26 December 2017

Survey of the year 2004: literature on applications of isothermal titration calorimetry

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Human interferon-gamma mRNA autoregulates its translation through a pseudoknot that activates the interferon-inducible protein kinase PKR

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Minor-groove recognition of double-stranded RNA by the double-stranded RNA-binding domain from the RNA-activated protein kinase PKR.

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The mRNA of the translationally controlled tumor protein P23/TCTP is a highly structured RNA, which activates the dsRNA-dependent protein kinase PKR

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NMR analysis of protein interactions

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PKR—A protein kinase regulated by double-stranded RNA

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Higher-Order Substrate Recognition of eIF2α by the RNA-Dependent Protein Kinase PKR

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Mechanistic Link between PKR Dimerization, Autophosphorylation, and eIF2α Substrate Recognition

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NMR spectroscopy of RNA.

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Dynamic Flexibility of Double-stranded RNA Activated PKR in Solution

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Molecular mechanisms of interferon resistance mediated by viral-directed inhibition of PKR, the interferon-induced protein kinase

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Translational control of viral gene expression in eukaryotes

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Mapping of the auto-inhibitory interactions of protein kinase R by nuclear magnetic resonance.

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Phosphorylation of the RNA-dependent protein kinase regulates its RNA-binding activity

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Specific recognition of HIV TAR RNA by the dsRNA binding domains (dsRBD1-dsRBD2) of PKR

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Mechanism of PKR activation: dimerization and kinase activation in the absence of double-stranded RNA.

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Unactivated PKR exists in an open conformation capable of binding nucleotides

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7 January 2021

Molecular basis for PKR activation by PACT or dsRNA

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Large-scale preparation and purification of polyacrylamide-free RNA oligonucleotides

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Mechanism of interferon action: RNA-binding activity of full-length and R-domain forms of the RNA-dependent protein kinase PKR--determination of KD values for VAI and TAR RNAs

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Uncoupling of RNA binding and PKR kinase activation by viral inhibitor RNAs

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Molecular framework for the activation of RNA-dependent protein kinase

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1H, 13C, 15N resonance assignment of the 20 kDa double stranded RNA binding domain of PKR

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7 January 2021

Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA-mediated activation

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A cis-acting element in the 3'-untranslated region of human TNF-alpha mRNA renders splicing dependent on the activation of protein kinase PKR.

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Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2

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Functional characterization of the RNA-binding domain and motif of the double-stranded RNA-dependent protein kinase DAI (PKR).

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Selective binding by the RNA binding domain of PKR revealed by affinity cleavage

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7 January 2021

Autophosphorylation sites participate in the activation of the double-stranded-RNA-activated protein kinase PKR

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7 January 2021

Inhibitory sequences in the N-terminus of the double-stranded-RNA-dependent protein kinase, PKR, are important for regulating phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha).

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The binding site of the RNA-dependent protein kinase (PKR) on EBER1 RNA from Epstein-Barr virus

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A model for the double-stranded RNA (dsRNA)-dependent dimerization and activation of the dsRNA-activated protein kinase PKR.

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7 January 2021

trans-Autophosphorylation by the isolated kinase domain is not sufficient for dimerization or activation of the dsRNA-activated protein kinase PKR.

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7 January 2021

Straightening of bulged RNA by the double-stranded RNA-binding domain from the protein kinase PKR.

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Identifiers

DOI

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26 December 2017

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26 December 2017