Peroxisome proliferator-activated receptor-beta/delta protects against chemically induced liver toxicity in mice (Q46882247)

26 December 2017

title

Peroxisome proliferator-activated receptor-beta/delta protects against chemically induced liver toxicity in mice (English)

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26 December 2017

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26 December 2017

author name string

Weiwei Shan

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26 December 2017

Christopher J Nicol

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26 December 2017

Shinji Ito

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26 December 2017

Mary J Kennett

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26 December 2017

Jerrold M Ward

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26 December 2017

Frank J Gonzalez

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26 December 2017

Jeffrey M Peters

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26 December 2017

language of work or name

English

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publication date

1 January 2008

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26 December 2017

published in

Hepatology

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26 December 2017

volume

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26 December 2017

issue

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26 December 2017

page(s)

225-235

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26 December 2017

Recent advances in peroxisome proliferator-activated receptor science

cites work

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The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas

21 January 2018

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The PPARs: from orphan receptors to drug discovery

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PPARs: therapeutic targets for metabolic disease

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Peroxisome proliferator-activated receptor alpha is restricted to hepatic parenchymal cells, not Kupffer cells: implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis.

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Peroxisome proliferator-activated receptor-alpha and liver cancer: where do we stand?

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PPAR gamma, 10 years later

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Peroxisome-proliferator-activated receptors and cancers: complex stories

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Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis.

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Peroxisome proliferator-activated receptor beta (delta)-dependent regulation of ubiquitin C expression contributes to attenuation of skin carcinogenesis.

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PPARbeta/delta selectively induces differentiation and inhibits cell proliferation

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Ligand activation of peroxisome proliferator-activated receptor beta inhibits colon carcinogenesis.

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Activation of PPARdelta alters lipid metabolism in db/db mice.

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A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport

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7 January 2021

Regulatory role of peroxisome proliferator-activated receptor delta (PPAR delta) in muscle metabolism. A new target for metabolic syndrome treatment?

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7 January 2021

PPARdelta regulates glucose metabolism and insulin sensitivity

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7 January 2021

Repeated dosing with the peroxisome proliferator clofibrate decreases the toxicity of model hepatotoxic agents in male mice

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7 January 2021

Protection by clofibrate against acetaminophen hepatotoxicity in male CD-1 mice is associated with an early increase in biliary concentration of acetaminophen-glutathione adducts

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7 January 2021

Peroxisome proliferator-activated receptor alpha-null mice lack resistance to acetaminophen hepatotoxicity following clofibrate exposure

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7 January 2021

Peroxisome proliferator-activated receptor-beta signaling contributes to enhanced proliferation of hepatic stellate cells.

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7 January 2021

Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta)

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7 January 2021

Proteomic profile of mouse fibroblasts with a targeted disruption of the peroxisome proliferator activated receptor-beta/delta gene.

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7 January 2021

Deregulation of tumor angiogenesis and blockade of tumor growth in PPARbeta-deficient mice

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7 January 2021

Peroxisome proliferator-activated receptor-beta/delta inhibits epidermal cell proliferation by down-regulation of kinase activity

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7 January 2021

Inhibition of chemically induced skin carcinogenesis by sulindac is independent of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta).

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7 January 2021

Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor

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7 January 2021

Hepatic expression of cytochrome P450s in hepatocyte nuclear factor 1-alpha (HNF1α)-deficient mice

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7 January 2021

Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.

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7 January 2021

Role of CYP2E1 in the hepatotoxicity of acetaminophen

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7 January 2021

Microarray Analysis Using Amplified mRNA from Laser Capture Microdissection of Microscopic Hepatocellular Precancerous Lesions and Frozen Hepatocellular Carcinomas Reveals Unique and Consistent Gene Expression Profiles

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7 January 2021

Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

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7 January 2021

Activators and target genes of Rel/NF-kappaB transcription factors

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7 January 2021

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat

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7 January 2021

Critical roles of PPAR beta/delta in keratinocyte response to inflammation

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7 January 2021

Molecular process in acute liver injury and regeneration induced by carbon tetrachloride.

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7 January 2021

Hepatotoxicity and Mechanism of Action of Haloalkanes: Carbon Tetrachloride as a Toxicological Model

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7 January 2021

Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1

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7 January 2021

A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma

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7 January 2021

Constitutive activation of peroxisome proliferator-activated receptor-gamma suppresses pro-inflammatory adhesion molecules in human vascular endothelial cells

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7 January 2021

Peroxisome proliferator-activated receptor beta/delta activation inhibits hypertrophy in neonatal rat cardiomyocytes

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7 January 2021

Cytokine regulation of liver injury and repair

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7 January 2021

Activation of Kupffer cells during the course of carbon tetrachloride-induced liver injury and fibrosis in rats

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7 January 2021

Pioglitazone prevents early-phase hepatic fibrogenesis caused by carbon tetrachloride.

1 reference

7 January 2021

TWEAK induces liver progenitor cell proliferation

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7 January 2021

The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling system regulates glioma cell survival via NFkappaB pathway activation and BCL-XL/BCL-W expression

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7 January 2021

The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling

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7 January 2021

Regulatory DNA elements of phenobarbital-responsive cytochrome P450 CYP2B genes

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7 January 2021

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

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7 January 2021

Resistance to carbon tetrachloride-induced hepatotoxicity in mice which lack CYP2E1 expression

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7 January 2021

Role of prostacyclin versus peroxisome proliferator-activated receptor beta receptors in prostacyclin sensing by lung fibroblasts

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7 January 2021

Isoform specific changes in PPAR alpha and beta in colon and breast cancer with differentiation

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7 January 2021

Ligand activation of peroxisome proliferator-activated receptor-beta/delta(PPARbeta/delta) inhibits cell growth of human N/TERT-1 keratinocytes

1 reference

7 January 2021

Peroxisome proliferator-activated receptor delta as a molecular target to regulate lung cancer cell growth

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7 January 2021

Effects of di(2-ethylhexyl) phthalate, a widely used peroxisome proliferator and plasticizer, on cell growth in the human keratinocyte cell line NCTC 2544.

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7 January 2021

Peroxisome proliferator-activated receptor expression and activation in normal human colonic epithelial cells and tubular adenomas

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7 January 2021

Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor beta/delta

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7 January 2021

Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT.

1 reference

7 January 2021

Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes

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7 January 2021

PPARβ/δ Regulates Paneth Cell Differentiation Via Controlling the Hedgehog Signaling Pathway

1 reference

7 January 2021

Modulation of keratinocyte gene expression and differentiation by PPAR-selective ligands and tetradecylthioacetic acid

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7 January 2021

PPARdelta status and Apc-mediated tumourigenesis in the mouse intestine

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7 January 2021

Inhibition of adult liver progenitor (oval) cell growth and viability by an agonist of the peroxisome proliferator activated receptor (PPAR) family member gamma, but not alpha or delta

1 reference

7 January 2021

Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPARdelta agonist, on development of steatohepatitis in mice fed a methionine- and choline-deficient diet

1 reference

7 January 2021

Transcriptional repression of atherogenic inflammation: modulation by PPARdelta

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7 January 2021

PPARbeta/delta protects against experimental colitis through a ligand-independent mechanism.

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7 January 2021

Identifiers

DOI

10.1002/HEP.21925

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26 December 2017

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26 December 2017