Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues (Q46836256)

25 December 2017

title

Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues (English)

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25 December 2017

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Anthony S Don

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25 December 2017

Carolina Martinez-Lamenca

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25 December 2017

William R Webb

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25 December 2017

Richard L Proia

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25 December 2017

Ed Roberts

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25 December 2017

Hugh Rosen

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25 December 2017

language of work or name

English

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publication date

30 March 2007

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25 December 2017

Journal of Biological Chemistry

published in

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25 December 2017

volume

282

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25 December 2017

issue

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25 December 2017

page(s)

15833-15842

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25 December 2017

Biologically active sphingolipids in cancer pathogenesis and treatment

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Sphingosine contributes to glucocorticoid-induced apoptosis of thymocytes independently of the mitochondrial pathway

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Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network

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Lysophospholipid receptor-dependent and -independent calcium signaling.

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Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors

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Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis

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Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis

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SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism

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Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling

21 January 2018

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FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors

21 January 2018

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Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists

21 January 2018

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Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720

21 January 2018

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Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

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FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance

21 January 2018

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FTY720, a fungus metabolite, inhibits in vivo growth of androgen-independent prostate cancer.

21 January 2018

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Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma.

21 January 2018

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T cell selective apoptosis by a novel immunosuppressant, FTY720, is closely regulated with Bcl-2.

21 January 2018

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A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells

21 January 2018

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Anticarcinogenic effect of FTY720 in human prostate carcinoma DU145 cells: modulation of mitogenic signaling, FAK, cell-cycle entry and apoptosis

21 January 2018

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Sphingosine-dependent apoptosis: a unified concept based on multiple mechanisms operating in concert

21 January 2018

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Sphingosine-dependent protein kinase-1, directed to 14-3-3, is identified as the kinase domain of protein kinase C delta

21 January 2018

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Endogenous substrates of sphingosine-dependent kinases (SDKs) are chaperone proteins: heat shock proteins, glucose-regulated proteins, protein disulfide isomerase, and calreticulin

21 January 2018

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Study of T-cell signaling by somatic cell mutagenesis and complementation cloning

21 January 2018

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Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720.

21 January 2018

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Essential role for sphingosine kinases in neural and vascular development

21 January 2018

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Fluorescence-based assay of sphingosine kinases

21 January 2018

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Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform

21 January 2018

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NBD-labeled derivatives of the immunomodulatory drug FTY720 as tools for metabolism and mode of action studies

21 January 2018

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The immune modulator FTY720 targets sphingosine 1-phosphate receptors

21 January 2018

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Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonist

21 January 2018

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Genetic, biochemical, and transcriptional responses of Saccharomyces cerevisiae to the novel immunomodulator FTY720 largely mimic those of the natural sphingolipid phytosphingosine

21 January 2018

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Sphingosine mediates FTY720-induced apoptosis in LLC-PK1 cells

21 January 2018

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Cellular response to endoplasmic reticulum stress: a matter of life or death

21 January 2018

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FTY720: dissection of membrane receptor-operated, stereospecific effects on cell migration from receptor-independent antiproliferative and apoptotic effects

21 January 2018

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Elevation of endogenous sphingolipid long-chain base phosphates kills Saccharomyces cerevisiae cells

21 January 2018

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Immunosuppressive activity of FTY720, sphingosine 1-phosphate receptor agonist: I. Prevention of allograft rejection in rats and dogs by FTY720 and FTY720-phosphate

21 January 2018

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The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity

21 January 2018

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Sphingolipid transport: rafts and translocators.

21 January 2018

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BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

21 January 2018

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Participation of endoplasmic reticulum and mitochondrial calcium handling in apoptosis: more than just neighborhood?

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M609124200

1 reference

25 December 2017

release_upi6ltnjqjaxjmdhjdlgxa4kjm

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/upi6ltnjqjaxjmdhjdlgxa4kjm

mapped directly with Wikidata item

24 November 2022

based on heuristic

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25 December 2017