Neuropsychopharmacological properties of neuroactive steroids in depression and anxiety disorders (Q46772911)

25 December 2017

title

Neuropsychopharmacological properties of neuroactive steroids in depression and anxiety disorders (English)

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25 December 2017

Peter Zwanzger

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25 December 2017

author name string

Daniela Eser

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25 December 2017

Cornelius Schüle

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25 December 2017

Elena Romeo

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25 December 2017

Thomas C Baghai

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25 December 2017

Flavia di Michele

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25 December 2017

Augusto Pasini

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25 December 2017

Frank Padberg

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25 December 2017

Rainer Rupprecht

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25 December 2017

publication date

25 October 2005

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25 December 2017

published in

Psychopharmacology

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25 December 2017

volume

186

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25 December 2017

issue

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25 December 2017

page(s)

373-387

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25 December 2017

Neurosteroid metabolism. 7 alpha-Hydroxylation of dehydroepiandrosterone and pregnenolone by rat brain microsomes

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Endogenous levels of dehydroepiandrosterone sulfate, but not other sex hormones, are associated with depressed mood in older women: the Rancho Bernardo Study

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Gonadal steroids in the treatment of mood disorders

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Effects of antidepressant treatment on neuroactive steroids in major depression

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00213-005-0188-Z

A double-blind randomised placebo controlled trial of postnatal norethisterone enanthate: the effect on postnatal depression and serum hormones

21 January 2018

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Dehydroepiandrosterone augmentation in the management of negative, depressive, and anxiety symptoms in schizophrenia

21 January 2018

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12 December 2020

Pituitary 5 alpha-dihydroprogesterone 3 alpha-hydroxysteroid oxidoreductases. Subcellular location and properties of NADH- and NADPH-linked activities

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12 December 2020

Double-blind treatment of major depression with dehydroepiandrosterone

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12 December 2020

The amygdala mediates the anxiolytic-like effect of the neurosteroid allopregnanolone in rat.

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12 December 2020

Dehydroepiandrosterone monotherapy in midlife-onset major and minor depression

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12 December 2020

Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes

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12 December 2020

Progesterone-induced changes in sleep in male subjects

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12 December 2020

Neurosteroids and GABAA receptor function.

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12 December 2020

No correlation of depression and anxiety to plasma estrogen and progesterone levels in patients with premenstrual dysphoric disorder

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12 December 2020

Neuroactive steroids: mechanisms of action and neuropsychopharmacological properties

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12 December 2020

Changes in cortisol and dehydroepiandrosterone in women victims of physical and psychological intimate partner violence

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12 December 2020

Investigation of the efficacy of progesterone pessaries in the relief of symptoms of premenstrual syndrome. progesterone Study Group

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12 December 2020

Endogenous concentrations of DHEA and DHEA-S decrease with remission of depression in older adults

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12 December 2020

The steroid and thyroid hormone receptor superfamily

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12 December 2020

Progesterone reduces immobility in rats forced to swim

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12 December 2020

Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation

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12 December 2020

An increased capacity for adrenal DHEA release is associated with decreased avoidance and negative mood symptoms in women with PTSD.

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12 December 2020

Plasma concentrations of anxiolytic neurosteroids in men with normal anxiety scores: a correlation analysis

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12 December 2020

Long-term low-dose dehydroepiandrosterone oral supplementation in early and late postmenopausal women modulates endocrine parameters and synthesis of neuroactive steroids

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12 December 2020

The antidepressant-like effect induced by sigma(1)-receptor agonists and neuroactive steroids in mice submitted to the forced swimming test

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12 December 2020

Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor

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12 December 2020

Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it.

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12 December 2020

Allopregnanolone in women with premenstrual syndrome

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12 December 2020

Elevated circulatory level of GABA(A)--antagonistic neurosteroids in patients with combat-related post-traumatic stress disorder.

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12 December 2020

Brain 5alpha-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation

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12 December 2020

Allopregnanolone concentrations and premenstrual syndrome

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12 December 2020

Effect of progesterone and its 5 alpha and 5 beta metabolites on symptoms of premenstrual syndrome according to route of administration

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12 December 2020

Dehydroepiandrosterone regulation of the hepatic glucocorticoid receptor in the Zucker rat. The obesity research program

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12 December 2020

GABA receptors, progesterone and premenstrual dysphoric disorder

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12 December 2020

Panic induction with cholecystokinin-tetrapeptide (CCK-4) Increases plasma concentrations of the neuroactive steroid 3alpha, 5alpha tetrahydrodeoxycorticosterone (3alpha, 5alpha-THDOC) in healthy volunteers

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12 December 2020

Concentrations of 3 alpha-reduced neuroactive steroids and their precursors in plasma of patients with major depression and after clinical recovery

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12 December 2020

Sensitivity to CCK-4 in women with and without premenstrual dysphoric disorder (PMDD) during their follicular and luteal phases.

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12 December 2020

Progesterone and the premenstrual syndrome: a double blind crossover trial

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12 December 2020

Adrenal steroid secretion and major depression in 8- to 16-year-olds, III. Influence of cortisol/DHEA ratio at presentation on subsequent rates of disappointing life events and persistent major depression

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12 December 2020

The neurosteroid dehydroepiandrosterone sulfate is an allosteric antagonist of the GABAA receptor

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12 December 2020

Differential anxiolytic effects of neurosteroids in the mirrored chamber behavior test in mice.

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12 December 2020

The neurosteroid tetrahydroprogesterone attenuates the endocrine response to stress and exerts glucocorticoid-like effects on vasopressin gene transcription in the rat hypothalamus

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12 December 2020

Dehydroepiandrosterone functions as more than an antiglucocorticoid in preserving immunocompetence after thermal injury

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12 December 2020

The socially-isolated mouse: a model to study the putative role of allopregnanolone and 5α-dihydroprogesterone in psychiatric disorders

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12 December 2020

Sleep and endocrine regulation

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12 December 2020

Ineffectiveness of progesterone suppository treatment for premenstrual syndrome

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12 December 2020

3 alpha-Hydroxy-5 beta-pregnan-20-one sulfate: a negative modulator of the NMDA-induced current in cultured neurons.

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12 December 2020

Behavioral, cardiovascular, and neuroendocrine profiles following CCK-4 challenge in healthy volunteers: a comparison of panickers and nonpanickers

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12 December 2020

Anxiolytic activity of an endogenous adrenal steroid

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12 December 2020

The 5 alpha-reductase in the brain: molecular aspects and relation to brain function

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12 December 2020

New insights into the role of neuroactive steroids in cognitive aging

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12 December 2020

Neonatal treatment of rats with the neuroactive steroid tetrahydrodeoxycorticosterone (THDOC) abolishes the behavioral and neuroendocrine consequences of adverse early life events

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12 December 2020

Neurosteroids: biosynthesis, metabolism and function of pregnenolone and dehydroepiandrosterone in the brain.

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12 December 2020

Dehydroepiandrosterone (DHEA) treatment of depression

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12 December 2020

GABA(A) receptor-modulating neuroactive steroid composition in patients with panic disorder before and during paroxetine treatment

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12 December 2020

Pregnenolone sulfate potentiation of N-methyl-D-aspartate receptor channels in hippocampal neurons

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12 December 2020

Neuroactive steroid levels in patients with generalized anxiety disorder

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12 December 2020

Anxiolytic activity of the progesterone metabolite 5α-pregnan-3α-ol-20-one

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12 December 2020

Pregnenolone sulfate antagonizes GABAA receptor-mediated currents via a reduction of channel opening frequency

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12 December 2020

Low pregnenolone sulphate plasma concentrations in patients with generalized social phobia

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12 December 2020

The pharmacology of neurosteroidogenesis

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12 December 2020

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12 December 2020

Sex-specific modulation of anxiety and locomotion after neonatal exposure to pregnenolone sulfate

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12 December 2020

5 alpha-pregnane-3 alpha, 21-diol-20-one (THDOC) attenuates mild stress-induced increases in plasma corticosterone via a non-glucocorticoid mechanism: comparison with alprazolam

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12 December 2020

Region-specific dysregulation of allopregnanolone brain content in the olfactory bulbectomized rat model of depression

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12 December 2020

Plasma concentrations of neuroactive steroids before and after electroconvulsive therapy in major depression

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12 December 2020

Anxiolytic activity of progesterone in progesterone receptor knockout mice.

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12 December 2020

The neurosteroid pregnenolone sulfate blocks deficits induced by a competitive NMDA antagonist in active avoidance and lever-press learning tasks in mice

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12 December 2020

The neuropsychopharmacological potential of neuroactive steroids

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12 December 2020

Neurosteroid secretion in panic disorder

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12 December 2020

Neurosteroids: biosynthesis and function of these novel neuromodulators

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12 December 2020

Neuroactive steroids are not affected by panic induction with 50 microg cholecystokinin-tetrapeptide (CCK-4) in healthy volunteers

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12 December 2020

Anxiolytic effect of progesterone is associated with increases in cortical allopregnanolone and GABAA receptor function

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12 December 2020

Antiglucocorticoid treatment of depression: double-blind ketoconazole

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12 December 2020

Behaviorally Selective Effects of Neuroactive Steroids on Plus-Maze Anxiety in Mice

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12 December 2020

Oestrogens and progestogens for preventing and treating postnatal depression

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12 December 2020

Antidepressant-like effect of the neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one in mice forced swim test

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12 December 2020

Differential change in neuroactive steroid sensitivity during ethanol withdrawal.

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12 December 2020

Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives

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12 December 2020

Comparative behavioral characterization of the neuroactive steroids 3α-OH,5α-pregnan-20-one and 3α-OH,5β-pregnan-20-one in rodents

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12 December 2020

Sigma (sigma1) receptor mediated anti-depressant-like effects of neurosteroids in the Porsolt forced swim test

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12 December 2020

Efficacy of progesterone vaginal suppositories in alleviation of nervous symptoms in patients with premenstrual syndrome

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12 December 2020

Progesterone increase under DHEA-substitution in males

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12 December 2020

Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus

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12 December 2020

Plasma concentrations of neuroactive steroids before and after repetitive transcranial magnetic stimulation (rTMS) in major depression

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12 December 2020

Neurosteroid pregnenolone sulfate antagonizes electrophysiological responses to GABA in neurons

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12 December 2020

Prevention of the stress-induced increase in the concentration of neuroactive steroids in rat brain by long-term administration of mirtazapine but not of fluoxetine

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12 December 2020

Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor

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12 December 2020

Chronic antidepressants reverse cerebrocortical allopregnanolone decline in the olfactory-bulbectomized rat.

1 reference

12 December 2020

CSF neuroactive steroids in affective disorders: pregnenolone, progesterone, and DBI.

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12 December 2020

Progesterone induces changes in sleep comparable to those of agonistic GABAA receptor modulators

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12 December 2020

Impairments in spatial learning and memory: ethanol, allopregnanolone, and the hippocampus

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12 December 2020

Synthesis, metabolism, and pharmacological activity of 3 alpha-hydroxy steroids which potentiate GABA-receptor-mediated chloride ion uptake in rat cerebral cortical synaptoneurosomes

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12 December 2020

Pregnenolone and pregnenolone sulfate, alone and with ethanol, in mice on the plus-maze

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12 December 2020

Pregnenolone sulfate antagonizes barbiturate-induced hypnosis

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12 December 2020

Altered salivary dehydroepiandrosterone levels in major depression in adults

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12 December 2020

Changes in progesterone metabolites in the hippocampus can modulate open field and forced swim test behavior of proestrous rats

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12 December 2020

Anti-anxiety effects of progesterone and some of its reduced metabolites: an evaluation using the burying behavior test

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12 December 2020

Characterization of the purified pituitary cytosolic NADPH:5 alpha-dihydroprogesterone 3 alpha-hydroxysteroid oxidoreductase

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12 December 2020

Neuroactive steroid changes in response to challenge with the panicogenic agent pentagastrin

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12 December 2020

Progesterone enhances motor, anxiolytic, analgesic, and antidepressive behavior of wild-type mice, but not those deficient in type 1 5 alpha-reductase

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12 December 2020

Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography

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12 December 2020

Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significance

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12 December 2020

Anxiolytic Effect of Progesterone is Mediated by the Neurosteroid Allopregnanolone at Brain GABAA Receptors

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12 December 2020

Influence of sleep deprivation on neuroactive steroids in major depression

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12 December 2020

Kinetics of allopregnanolone formation catalyzed by human 3 alpha-hydroxysteroid dehydrogenase type III (AKR1C2).

1 reference

12 December 2020

A double-blind trial of oral progesterone, alprazolam, and placebo in treatment of severe premenstrual syndrome

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12 December 2020

Adrenal androgens and cortisol in major depression

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12 December 2020

Is there a physiological role for the neurosteroid THDOC in stress-sensitive conditions?

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12 December 2020

Permissive role of brain allopregnanolone content in the regulation of pentobarbital-induced righting reflex loss

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12 December 2020

Can the antidysphoric and anxiolytic profiles of selective serotonin reuptake inhibitors be related to their ability to increase brain 3 alpha, 5 alpha-tetrahydroprogesterone (allopregnanolone) availability?

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12 December 2020

Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine

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12 December 2020

Elevated levels of some neuroactive progesterone metabolites, particularly isopregnanolone, in women with chronic fatigue syndrome

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12 December 2020

Elevated blood levels of dehydroepiandrosterone sulphate vary with symptom load in posttraumatic stress disorder: findings from a longitudinal study of refugees in Sweden

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12 December 2020

Serum concentrations of some neuroactive steroids in women suffering from mixed anxiety-depressive disorder

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12 December 2020

Dehydroepiandrosterone is an anxiolytic in mice on the plus maze

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12 December 2020

The neurosteroid tetrahydroprogesterone counteracts corticotropin-releasing hormone-induced anxiety and alters the release and gene expression of corticotropin-releasing hormone in the rat hypothalamus

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12 December 2020

Gonadal, adrenal, and neuroactive steroids' role in ictal activity

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12 December 2020

Neurosteroids: a new function in the brain

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12 December 2020

Dehydroepiandrosterone treatment of midlife dysthymia

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12 December 2020

Induced panic attacks shift gamma-aminobutyric acid type A receptor modulatory neuroactive steroid composition in patients with panic disorder: preliminary results

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12 December 2020

Anxiolytic effects of 3α-hydroxy-5α[β]-pregnan-20-one: endogenous metabolites of progesterone that are active at the GABAA receptor

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12 December 2020

Neuroactive steroids and suicidality in posttraumatic stress disorder

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12 December 2020

Circulating levels of anxiolytic steroids in the luteal phase in women with premenstrual syndrome and in control subjects

1 reference

12 December 2020

Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain

1 reference

12 December 2020

A double-blind randomised placebo controlled trial of postnatal norethisterone enanthate: the effect on postnatal depression and serum hormones

1 reference

12 December 2020

Basal plasma dehydroepiandrosterone sulfate level: a possible predictor for response to electroconvulsive therapy in depressed psychotic inpatients.

1 reference

12 December 2020

Time-dependent changes in rat brain neuroactive steroid concentrations and GABAA receptor function after acute stress

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12 December 2020

Serum dehydroepiandrosterone sulfate levels as an individual marker

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12 December 2020

Pregneolone--from Selye to Alzheimer and a model of the pregnenolone sulfate binding site on the GABAA receptor

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12 December 2020

Increased diurnal plasma concentrations of dehydroepiandrosterone in depressed patients

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12 December 2020

Role of neurosteroids in catamenial epilepsy.

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12 December 2020

Opposite effects of short- versus long-term administration of fluoxetine on the concentrations of neuroactive steroids in rat plasma and brain

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12 December 2020

Influence of ovariectomy, estradiol and progesterone on the behavior of mice in an experimental model of depression

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12 December 2020

Fluoxetine decreases concentrations of 3 alpha, 5 alpha-tetrahydrodeoxycorticosterone (THDOC) in major depression

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12 December 2020

10.1007/S00213-005-0188-Z

Identifiers

DOI

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25 December 2017

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25 December 2017