The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism (Q46666883)

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scientific article published on 3 April 2008

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English	The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism	scientific article published on 3 April 2008

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism (English)

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

multiple drug resistance

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based on heuristic

inferred from title

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James A. McCubrey

8

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Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

author name string

F Chiarini

1

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Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

M Del Sole

2

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Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

S Mongiorgi

3

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

G C Gaboardi

4

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Europe PubMed Central

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24 December 2017

http://europepmc.org/abstract/MED/18385752

A Cappellini

5

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Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

I Mantovani

6

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24 December 2017

http://europepmc.org/abstract/MED/18385752

M Y Follo

7

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Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

A M Martelli

9

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PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

publication date

3 April 2008

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Europe PubMed Central

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24 December 2017

http://europepmc.org/abstract/MED/18385752

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Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

22

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24 December 2017

http://europepmc.org/abstract/MED/18385752

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PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

1106-1116

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Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

Regulation of PTEN function as a PIP3 gatekeeper through membrane interaction

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

21 January 2018

A phase II trial of perifosine, an oral alkylphospholipid, in recurrent or metastatic head and neck cancer.

1 reference

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21 January 2018

A primer on the mechanics of P-glycoprotein the multidrug transporter.

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ABC transporters and drug resistance in leukemia: was P-gp nothing but the first head of the Hydra?

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7 January 2021

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Multidrug resistance in cancer: role of ATP-dependent transporters

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The farnesyl transferase inhibitor, tipifarnib, is a potent inhibitor of the MDR1 gene product, P-glycoprotein, and demonstrates significant cytotoxic synergism against human leukemia cell lines

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Onconase induces caspase-independent cell death in chemoresistant neuroblastoma cells

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Identification of a novel synthetic thiazolidin compound capable of inducing c-Jun NH2-terminal kinase-dependent apoptosis in human colon cancer cells

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Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.

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The insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 induces apoptosis in acute myeloid leukemia cells exhibiting autocrine insulin-like growth factor-I secretion

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Autocrine insulin-like growth factor-I signaling promotes growth and survival of human acute myeloid leukemia cells via the phosphoinositide 3-kinase/Akt pathway

1 reference

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7 January 2021

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AKT/PKB signaling: navigating downstream

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7 January 2021

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The Akt/PKB pathway: molecular target for cancer drug discovery

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7 January 2021

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A phase I trial of perifosine (NSC 639966) on a loading dose/maintenance dose schedule in patients with advanced cancer

1 reference

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7 January 2021

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Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts.

1 reference

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7 January 2021

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Phase I and pharmacological study of daily oral administration of perifosine (D-21266) in patients with advanced solid tumours

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https://api.crossref.org/works/10.1038%2FLEU.2008.79

7 January 2021

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The alkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathway

1 reference

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7 January 2021

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Handicapping the race to develop inhibitors of the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway

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7 January 2021

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Synergistic induction of apoptosis in human leukemia T cells by the Akt inhibitor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathways

1 reference

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7 January 2021

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Caspase-dependent cleavage of 170-kDa P-glycoprotein during apoptosis of human T-lymphoblastoid CEM cells

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7 January 2021

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Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells

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7 January 2021

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Rationale and clinical application of alkylphospholipid analogues in combination with radiotherapy

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A role for nuclear phospholipase Cbeta 1 in cell cycle control

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Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts

1 reference

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7 January 2021

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Inhibition of phosphatidylinositol 3'-kinase induces preferentially killing of PTEN-null T leukemias through AKT pathway.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.79

7 January 2021

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Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells

1 reference

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7 January 2021

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Enhancement of stress-induced apoptosis in B-lineage cells by caspase-9 inhibitor.

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Cytochrome c oxidase

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Thermodynamics of intersubunit interactions in cholera toxin upon binding to the oligosaccharide portion of its cell surface receptor, ganglioside GM1.

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The antitumor ether lipid ET-18-OCH(3) induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells

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Structural and functional analyses of the promoter of the murine multidrug resistance gene mdr3/mdr1a reveal a negative element containing the AP-1 binding site

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Reversal of P-glycoprotein-mediated multidrug resistance in cancer cells by the c-Jun NH2-terminal kinase

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P-glycoprotein and 'lipid rafts': some ambiguous mutual relationships (floating on them, building them or meeting them by chance?).

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Modulation of cellular cholesterol alters P-glycoprotein activity in multidrug-resistant cells

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A new class of anticancer alkylphospholipids uses lipid rafts as membrane gateways to induce apoptosis in lymphoma cells

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Rapamycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells

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MDR1 protein expression is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia.

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10.1038/LEU.2008.79

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

release_j5n4w4fb4bgzrermapqkl65dxq

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https://api.fatcat.wiki/v0/release/j5n4w4fb4bgzrermapqkl65dxq

24 November 2022

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18385752

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