Optimizing hyaluronidase dose and plasmid DNA delivery greatly improves gene electrotransfer efficiency in rat skeletal muscle (Q46651262)

24 December 2017

title

Optimizing hyaluronidase dose and plasmid DNA delivery greatly improves gene electrotransfer efficiency in rat skeletal muscle (English)

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24 December 2017

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24 December 2017

Thorbjörn Åkerström

object named as

Thorbjorn Akerstrom

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Jørgen Wojtaszewski

object named as

Jørgen F P Wojtaszewski

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24 December 2017

author name string

Thorbjorn Akerstrom

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24 December 2017

Kenneth Vedel

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24 December 2017

Josefine Needham

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24 December 2017

Pernille Hojman

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24 December 2017

Eftychia Kontou

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24 December 2017

publication date

22 October 2015

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24 December 2017

Biochemistry and Biophysics Reports

published in

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24 December 2017

volume

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24 December 2017

page(s)

342-350

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24 December 2017

describes a project that uses

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5669402/fullTextXML

inferred from PubMed Central ID database lookup

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Gene electrotransfer of plasmid antiangiogenic metargidin peptide (AMEP) in disseminated melanoma: safety and efficacy results of a phase I first-in-man study

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Efficiency of high- and low-voltage pulse combinations for gene electrotransfer in muscle, liver, tumor, and skin.

24 May 2018

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24 May 2018

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Gene expression profiles in skeletal muscle after gene electrotransfer

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Electrically induced DNA uptake by cells is a fast process involving DNA electrophoresis

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Optimizing plasmid-based gene transfer for investigating skeletal muscle structure and function

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Electrophoretic component of electric pulses determines the efficacy of in vivo DNA electrotransfer.

15 August 2018

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A comprehensive study of optimal conditions for naked plasmid DNA transfer into skeletal muscle by electroporation

15 August 2018

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Gene expression and immune response kinetics using electroporation-mediated DNA delivery to muscle

15 August 2018

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15 August 2018

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15 August 2018

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15 August 2018

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15 August 2018

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Optimal salt concentration of vehicle for plasmid DNA enhances gene transfer mediated by electroporation

15 August 2018

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Hyaluronidase increases electrogene transfer efficiency in skeletal muscle

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5669402

Optimisation of electrotransfer of plasmid into skeletal muscle by pretreatment with hyaluronidase -- increased expression with reduced muscle damage

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5669402

Dynamics of nuclei of muscle fibers and connective tissue cells in normal and denervated rat muscles.

15 August 2018

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Inflammatory responses following direct injection of plasmid DNA into skeletal muscle

15 August 2018

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Long-term, high level in vivo gene expression after electric pulse-mediated gene transfer into skeletal muscle.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5669402

Composition and size of type I, IIA, IID/X, and IIB fibers and citrate synthase activity of rat muscle

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5669402

Intramuscular plasmid DNA electrotransfer: biodistribution and degradation

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5669402

Overexpression of carnitine palmitoyltransferase I in skeletal muscle in vivo increases fatty acid oxidation and reduces triacylglycerol esterification

1 December 2018

1 reference

12 December 2020

Brief Report: Muscle Transfection by Electroporation with High-Voltage and Short-Pulse Currents Provides High-Level and Long-Lasting Gene Expression

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12 December 2020

In vivo plasmid DNA electroporation resulted in transfection of satellite cells and lasting transgene expression in regenerated muscle fibers

1 reference

12 December 2020

Insulin-like growth factor-I gene transfer by electroporation prevents skeletal muscle atrophy in glucocorticoid-treated rats

1 reference

12 December 2020

Interleukin-10 expression after intramuscular DNA electrotransfer: kinetic studies

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12 December 2020

Enhanced in vivo delivery of antisense oligonucleotides to restore dystrophin expression in adult mdx mouse muscle

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12 December 2020

Erythropoietin secretion and physiological effect in mouse after intramuscular plasmid DNA electrotransfer

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12 December 2020

High-level protein secretion into blood circulation after electric pulse-mediated gene transfer into skeletal muscle

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12 December 2020

Oxygen uptake of rats at different work intensities

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12 December 2020

Importance of association between permeabilization and electrophoretic forces for intramuscular DNA electrotransfer

1 reference

12 December 2020

Fatty acid binding protein facilitates sarcolemmal fatty acid transport but not mitochondrial oxidation in rat and human skeletal muscle

1 reference

12 December 2020

Hyaluronidase contributes to early inflammatory events induced by electrotransfer in mouse skeletal muscle

1 reference

12 December 2020

Mechanisms of in Vivo DNA Electrotransfer: Respective Contributions of Cell Electropermeabilization and DNA Electrophoresis

1 reference

12 December 2020

Factors influencing the efficacy, longevity, and safety of electroporation-assisted plasmid-based gene transfer into mouse muscles

1 reference

12 December 2020

Muscle fiber type composition of the rat hindlimb

1 reference

12 December 2020

10.1016/J.BBREP.2015.10.007

Identifiers

DOI

1 reference

24 December 2017

PMC publication ID

5669402

1 reference

24 December 2017

PubMed publication ID

29124223

1 reference

24 December 2017