Improving Assessment of Drug Safety Through Proteomics: Early Detection and Mechanistic Characterization of the Unforeseen Harmful Effects of Torcetrapib (Q46562930)

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scientific article published on 3 October 2017

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English	Improving Assessment of Drug Safety Through Proteomics: Early Detection and Mechanistic Characterization of the Unforeseen Harmful Effects of Torcetrapib	scientific article published on 3 October 2017

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5839936

Improving Assessment of Drug Safety Through Proteomics: Early Detection and Mechanistic Characterization of the Unforeseen Harmful Effects of Torcetrapib (English)

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5839936

Anders Mälarstig

5

object named as

Anders Malarstig

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5839936

author name string

Stephen A Williams

1

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5839936

Ashwin C Murthy

2

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5839936

Robert K DeLisle

3

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5839936

Craig Hyde

4

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5839936

Rachel Ostroff

6

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5839936

Sophie J Weiss

7

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5839936

Mark R Segal

8

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5839936

Peter Ganz

9

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5839936

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publication date

3 October 2017

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5839936

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5839936

137

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5839936

10

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5839936

999-1010

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5839936

Troponin release following brief myocardial ischemia: apoptosis versus necrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839936

14 June 2018

Aptamer-Based Proteomic Profiling Reveals Novel Candidate Biomarkers and Pathways in Cardiovascular Disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839936

14 June 2018

Transformative Impact of Proteomics on Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839936

14 June 2018

Inflammation and immunity in diseases of the arterial tree: players and layers

1 reference

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14 June 2018

HDL and cholesterol: life after the divorce?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839936

14 June 2018

Effects of dalcetrapib in patients with a recent acute coronary syndrome

1 reference

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14 June 2018

Estimating glomerular filtration rate from serum creatinine and cystatin C.

1 reference

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14 June 2018

Life's simple measures: unlocking the proteome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839936

14 June 2018

Risk prediction measures for case-cohort and nested case-control designs: an application to cardiovascular disease

1 reference

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14 June 2018

Ten years of pathway analysis: current approaches and outstanding challenges

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839936

14 June 2018

Effect of torcetrapib on glucose, insulin, and hemoglobin A1c in subjects in the Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events (ILLUMINATE) trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839936

14 June 2018

Aptamer-based multiplexed proteomic technology for biomarker discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839936

14 June 2018

Cardiac troponin may be released by ischemia alone, without necrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839936

14 June 2018

Cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer protein inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839936

14 June 2018

Dysfunctional HDL as a diagnostic and therapeutic target

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839936

14 June 2018

Mendelian randomization: nature's randomized trial in the post-genome era.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839936

14 June 2018

Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839936

14 June 2018

Limit of blank, limit of detection and limit of quantitation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839936

14 June 2018

Discovery of a cytokine and its receptor by functional screening of the extracellular proteome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839936

14 June 2018

Effects of torcetrapib in patients at high risk for coronary events

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839936

14 June 2018

Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839936

14 June 2018

Risk of cardiovascular events associated with selective COX-2 inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839936

14 June 2018

Development and Validation of a Protein-Based Risk Score for Cardiovascular Outcomes Among Patients With Stable Coronary Heart Disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839936

16 June 2018

Achievement of dual low-density lipoprotein cholesterol and high-sensitivity C-reactive protein targets more frequent with the addition of ezetimibe to simvastatin and associated with better outcomes in IMPROVE-IT.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839936

16 June 2018

Using Aptamer-Based Technology to Probe the Plasma Proteome for Cardiovascular Disease Prediction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839936

15 August 2018

Biomarkers and Surrogate Endpoints: Developing Common Terminology and Definitions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839936

15 August 2018

ILLUMINATE sheds more light.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839936

15 August 2018

The lessons of Vioxx--drug safety and sales

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839936

15 August 2018

Intensive lipid lowering with atorvastatin in patients with stable coronary disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839936

15 August 2018

Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839936

15 August 2018

C-reactive protein levels and outcomes after statin therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839936

15 August 2018

Primary and subsequent coronary risk appraisal: new results from the Framingham study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839936

15 August 2018

Reducing LDL with PCSK9 Inhibitors--The Clinical Benefit of Lipid Drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/28974520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The failure of torcetrapib: was it the molecule or the mechanism?

1 reference

https://pubmed.ncbi.nlm.nih.gov/28974520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical relevance of C-reactive protein during follow-up of patients with acute coronary syndromes in the Aggrastat-to-Zocor Trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/28974520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifying Low-Abundance Biomarkers: Aptamer-Based Proteomics Potentially Enables More Sensitive Detection in Cardiovascular Diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/28974520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1161/CIRCULATIONAHA.117.028213

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5839936

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5839936

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5839936

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