Urokinase-type plasminogen activator receptor induces conformational changes in the integrin alphaMbeta2 headpiece and reorientation of its transmembrane domains (Q46470855)

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scientific article published on 21 July 2008

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English	Urokinase-type plasminogen activator receptor induces conformational changes in the integrin alphaMbeta2 headpiece and reorientation of its transmembrane domains	scientific article published on 21 July 2008

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18644795

Urokinase-type plasminogen activator receptor induces conformational changes in the integrin alphaMbeta2 headpiece and reorientation of its transmembrane domains (English)

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18644795

transmembrane protein

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author name string

Man-Li Tang

1

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18644795

Ardcharaporn Vararattanavech

2

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18644795

Suet-Mien Tan

3

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Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18644795

language of work or name

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publication date

21 July 2008

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Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18644795

number of pages

12

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Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18644795

283

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Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18644795

37

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18644795

25392-25403

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18644795

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Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand

1 reference

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Ligand binding to integrins

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The Mac-1 and p150,95 beta 2 integrins bind denatured proteins to mediate leukocyte cell-substrate adhesion

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Transendothelial migration and trafficking of leukocytes in LFA-1-deficient mice

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LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice

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Complement receptor 3 ligation of dendritic cells suppresses their stimulatory capacity

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The apoptotic-cell receptor CR3, but not alphavbeta5, is a regulator of human dendritic-cell immunostimulatory function

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Urokinase plasminogen activator receptor, beta 2-integrins, and Src-kinases within a single receptor complex of human monocytes

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Convergence of the adhesive and fibrinolytic systems: recognition of urokinase by integrin alpha Mbeta 2 as well as by the urokinase receptor regulates cell adhesion and migration

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Urokinase-type plasminogen activator receptor (CD87) is a ligand for integrins and mediates cell-cell interaction.

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uPAR: a versatile signalling orchestrator

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Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding.

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Urokinase receptors are required for alpha 5 beta 1 integrin-mediated signaling in tumor cells

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Structural basis of integrin regulation and signaling

1 reference

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Structure and mechanics of integrin-based cell adhesion.

1 reference

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Identification of a urokinase receptor-integrin interaction site. Promiscuous regulator of integrin function

1 reference

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21 January 2018

Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide

1 reference

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21 January 2018

Integrin structure, allostery, and bidirectional signaling

1 reference

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Requirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signaling

1 reference

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KIM185, a monoclonal antibody to CD18 which induces a change in the conformation of CD18 and promotes both LFA‐1‐ and CR3‐dependent adhesion

1 reference

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21 January 2018

Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation

1 reference

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21 January 2018

Down-regulation of integrin alpha M beta 2 ligand-binding function by the urokinase-type plasminogen activator receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802311200

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Epitope mapping of monoclonal antibody to integrin alphaL beta2 hybrid domain suggests different requirements of affinity states for intercellular adhesion molecules (ICAM)-1 and ICAM-3 binding

1 reference

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Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins

1 reference

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Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics

1 reference

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Epitope mapping of antibodies to the C-terminal region of the integrin beta 2 subunit reveals regions that become exposed upon receptor activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802311200

21 January 2018

Mutation of a conserved asparagine in the I-like domain promotes constitutively active integrins alphaLbeta2 and alphaIIbbeta3.

1 reference

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21 January 2018

Detection of constitutive heterodimerization of the integrin Mac-1 subunits by fluorescence resonance energy transfer in living cells

1 reference

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Structure of the Integrin IIb Transmembrane Segment

1 reference

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Structure of the integrin beta3 transmembrane segment in phospholipid bicelles and detergent micelles

1 reference

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Concurrent upregulation of urokinase plasminogen activator receptor and CD11b during tuberculosis and experimental endotoxemia

1 reference

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A specific interface between integrin transmembrane helices and affinity for ligand

1 reference

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An essential role for talin during alpha(M)beta(2)-mediated phagocytosis

1 reference

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Integrin alphaMbeta2 orchestrates and accelerates plasminogen activation and fibrinolysis by neutrophils

1 reference

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Regulation of CD11b/CD18 (Mac-1) adhesion to fibrinogen by urokinase receptor (uPAR).

1 reference

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Urokinase-deficient and urokinase receptor-deficient mice have impaired neutrophil antimicrobial activation in vitro

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Urokinase receptor-deficient mice have impaired neutrophil recruitment in response to pulmonary Pseudomonas aeruginosa infection

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Activated conformations of very late activation integrins detected by a group of antibodies (HUTS) specific for a novel regulatory region (355-425) of the common beta 1 chain

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Structure of integrin alpha5beta1 in complex with fibronectin

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Dimerization controls the lipid raft partitioning of uPAR/CD87 and regulates its biological functions

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Three-dimensional EM structure of the ectodomain of integrin {alpha}V{beta}3 in a complex with fibronectin

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Dissociation of I domain and global conformational changes in LFA-1: refinement of small molecule-I domain structure-activity relationships

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Structure of human urokinase plasminogen activator in complex with its receptor

1 reference

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Cation binding to the integrin CD11b I domain and activation model assessment

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Conformational Changes in the Integrin βA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement

1 reference

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KIM127, an antibody that promotes adhesion, maps to a region of CD18 that includes cysteine-rich repeats.

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Identifiers

10.1074/JBC.M802311200

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18644795

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18644795

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