X-ray structure of plasmepsin II complexed with a potent achiral inhibitor (Q46445865)

22 December 2017

title

X-ray structure of plasmepsin II complexed with a potent achiral inhibitor (English)

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22 December 2017

author name string

Lars Prade

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22 December 2017

Andrew F Jones

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22 December 2017

Christoph Boss

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22 December 2017

Sylvia Richard-Bildstein

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22 December 2017

Solange Meyer

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22 December 2017

Christoph Binkert

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22 December 2017

Daniel Bur

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22 December 2017

language of work or name

English

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publication date

19 April 2005

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22 December 2017

Journal of Biological Chemistry

number of pages

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based on heuristic

inferred from page(s)

published in

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22 December 2017

volume

280

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22 December 2017

issue

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22 December 2017

page(s)

23837-23843

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22 December 2017

Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodium falciparum

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Cellular uptake of chloroquine is dependent on binding to ferriprotoporphyrin IX and is independent of NHE activity in Plasmodium falciparum

21 January 2018

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Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine

21 January 2018

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The role of Plasmodium falciparum food vacuole plasmepsins

21 January 2018

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A distinct member of the aspartic proteinase gene family from the human malaria parasite Plasmodium falciparum

21 January 2018

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Potent inhibitors of the Plasmodium falciparum enzymes plasmepsin I and II devoid of cathepsin D inhibitory activity

21 January 2018

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Inhibitors of the Plasmodium falciparum parasite aspartic protease plasmepsin II as potential antimalarial agents

21 January 2018

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Design and synthesis of potent inhibitors of the malaria aspartyl proteases plasmepsin I and II. Use of solid-phase synthesis to explore novel statine motifs

21 January 2018

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New class of small nonpeptidyl compounds blocks Plasmodium falciparum development in vitro by inhibiting plasmepsins

21 January 2018

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High-affinity inhibition of a family of Plasmodium falciparum proteases by a designed adaptive inhibitor

21 January 2018

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De Novo design, synthesis, and in vitro evaluation of a new class of nonpeptidic inhibitors of the malarial enzyme plasmepsin II.

21 January 2018

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Novel uncomplexed and complexed structures of plasmepsin II, an aspartic protease from Plasmodium falciparum

21 January 2018

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Structure and inhibition of plasmepsin II, a hemoglobin-degrading enzyme from Plasmodium falciparum

21 January 2018

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High level expression and characterisation of Plasmepsin II, an aspartic proteinase from Plasmodium falciparum.

21 January 2018

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The CCP4 suite: programs for protein crystallography

21 January 2018

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The interpretation of protein structures: Estimation of static accessibility

21 January 2018

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Genetic disruption of the Plasmodium falciparum digestive vacuole plasmepsins demonstrates their functional redundancy

21 January 2018

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Extracting hydrophobic free energies from experimental data: relationship to protein folding and theoretical models

21 January 2018

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Crystal structure of the novel aspartic proteinase zymogen proplasmepsin II from plasmodium falciparum

21 January 2018

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Atomic resolution analysis of the catalytic site of an aspartic proteinase and an unexpected mode of binding by short peptides

21 January 2018

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Identification of a small molecule nonpeptide active site beta-secretase inhibitor that displays a nontraditional binding mode for aspartyl proteases

21 January 2018

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Distal substrate interactions enhance plasmepsin activity

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M501519200

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22 December 2017

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22 December 2017