Rho/ROCK and MEK/ERK activation by transforming growth factor-alpha induces articular cartilage degradation (Q46355550)

21 December 2017

title

Rho/ROCK and MEK/ERK activation by transforming growth factor-alpha induces articular cartilage degradation (English)

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21 December 2017

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21 December 2017

Frank Beier

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21 December 2017

author name string

Shirine E Usmani

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21 December 2017

John S Mort

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21 December 2017

publication date

12 October 2009

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21 December 2017

published in

Laboratory Investigation

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21 December 2017

volume

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21 December 2017

issue

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21 December 2017

page(s)

20-30

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21 December 2017

Understanding NSAIDs: from aspirin to COX-2

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RhoA/ROCK signaling regulates Sox9 expression and actin organization during chondrogenesis.

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RhoA/ROCK signaling regulates chondrogenesis in a context-dependent manner.

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RhoA/ROCK signaling suppresses hypertrophic chondrocyte differentiation.

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The MEK-ERK Signaling Pathway Is a Negative Regulator of Cartilage-specific Gene Expression in Embryonic Limb Mesenchyme

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Activation of interleukin-1 signaling cascades in normal and osteoarthritic articular cartilage

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Aggrecan degradation in human intervertebral disc and articular cartilage

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Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage

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Requirement for RAR-mediated gene repression in skeletal progenitor differentiation

21 January 2018

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The transcription factor ATF3 is upregulated during chondrocyte differentiation and represses cyclin D1 and A gene transcription

21 January 2018

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Citron kinase, a Rho-dependent kinase, induces di-phosphorylation of regulatory light chain of myosin II

21 January 2018

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Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase

21 January 2018

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L-Sox5, Sox6 and Sox9 control essential steps of the chondrocyte differentiation pathway

21 January 2018

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SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene

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Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C delta-dependent pathway

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Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability.

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TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage

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p38 MAP kinase signalling is required for hypertrophic chondrocyte differentiation

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Bcl-2 positively regulates Sox9-dependent chondrocyte gene expression by suppressing the MEK-ERK1/2 signaling pathway

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IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPK.

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Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytes

21 January 2018

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Increased expression of matrilin-3 not only in osteoarthritic articular cartilage but also in cartilage-forming tumors, and down-regulation of SOX9 via epidermal growth factor domain 1-dependent signaling.

21 January 2018

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21 January 2018

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7 January 2021

https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

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7 January 2021

Global analyses of gene expression in early experimental osteoarthritis

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https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

7 January 2021

Transforming growth factor alpha suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis

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https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

7 January 2021

Sustained and distinctive patterns of gene activation in synovial fibroblasts and whole synovial tissue obtained from inflammatory synovitis

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https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

7 January 2021

IL-1beta induction of IL-6 and LIF in normal articular human chondrocytes involves the ERK, p38 and NFkappaB signaling pathways

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https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

7 January 2021

TNFα suppresses link protein and type II collagen expression in chondrocytes: Role of MEK1/2 and NF‐κB signaling pathways

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https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

7 January 2021

Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels

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7 January 2021

Epidermal growth factor negatively regulates chondrogenesis of mesenchymal cells by modulating the protein kinase C-alpha, Erk-1, and p38 MAPK signaling pathways

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https://api.crossref.org/works/10.1038%2FLABINVEST.2009.111

7 January 2021

10.1038/LABINVEST.2009.111

Identifiers

DOI

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21 December 2017

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21 December 2017