Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans. (Q46321806)

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English	Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans.	scientific article

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23 December 2019

Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans (English)

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23 December 2019

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Caenorhabditis elegans

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William L. Klein

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William L Klein

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23 December 2019

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Yanjue Wu

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23 December 2019

Zhixin Wu

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23 December 2019

Peter Butko

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23 December 2019

Yves Christen

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23 December 2019

Mary P Lambert

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23 December 2019

Christopher D Link

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23 December 2019

Yuan Luo

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1 December 2006

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23 December 2019

Journal of Neuroscience

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23 December 2019

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23 December 2019

50

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23 December 2019

13102-13113

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23 December 2019

A 26-week analysis of a double-blind, placebo-controlled trial of the ginkgo biloba extract EGb 761 in dementia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by beta-amyloid.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Ginkgo biloba extract EGb 761 rescues the PC12 neuronal cells from beta-amyloid-induced cell death by inhibiting the formation of beta-amyloid-derived diffusible neurotoxic ligands.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The in vivo neuromodulatory effects of the herbal medicine ginkgo biloba

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in the Caenorhabditis elegans serotonin reuptake transporter MOD-5 reveal serotonin-dependent and -independent activities of fluoxetine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vaccination with soluble Abeta oligomers generates toxicity-neutralizing antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular amyloid-beta 1-42, but not extracellular soluble amyloid-beta peptides, induces neuronal apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

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Serotonin mediates food-odor associative learning in the nematode Caenorhabditiselegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of amyloid-beta aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ginkgo biloba neuroprotection: Therapeutic implications in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

What is Ginkgo biloba extract EGb 761? An overview--from molecular biology to clinical medicine

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A double-blind, placebo-controlled, randomized trial of Ginkgo biloba extract EGb 761 in a sample of cognitively intact older adults: neuropsychological findings

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral plasticity in C. elegans: paradigms, circuits, genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ginkgo biloba for cognitive impairment and dementia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer's disease model

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress precedes fibrillar deposition of Alzheimer's disease amyloid beta-peptide (1-42) in a transgenic Caenorhabditis elegans model

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of Alzheimer's disease onset with ginkgo biloba and other symptomatic cognitive treatments in a population of women aged 75 years and older from the EPIDOS study

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Magnitude of effect and special approach to Ginkgo biloba extract EGb 761 in cognitive disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Terpene trilactones from Ginkgo biloba are antagonists of cortical glycine and GABA(A) receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the small heat-shock protein Hsp16-2 in Caenorhabditis elegans is suppressed by Ginkgo biloba extract EGb 761.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of hippocampal LTP by ginkgolide B is mediated by its blocking action on PAF rather than glycine receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Self-assembly of Abeta(1-42) into globular neurotoxins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevation of oxidative free radicals in Alzheimer's disease models can be attenuated by Ginkgo biloba extract EGb 761

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of age-related spatial memory deficits in a transgenic mouse model of Alzheimer's disease by chronic Ginkgo biloba treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oligomers on the brain: the emerging role of soluble protein aggregates in neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Testing the amyloid toxicity hypothesis of Alzheimer's disease in transgenic Caenorhabditis elegans model

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation of ginkgolides A, B, C, J and bilobalide from G. biloba extracts

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In silico study of amyloid beta-protein folding and oligomerization

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of Alzheimer Abeta peptides in ion transport across cell membranes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Invertebrate models of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transgenic C. elegans as a model in Alzheimer's research

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Terpene trilactones from Gingko biloba: from ancient times to the 21st century

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conversion of green fluorescent protein into a toxic, aggregation-prone protein by C-terminal addition of a short peptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathogenic bacteria induce aversive olfactory learning in Caenorhabditis elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions between Caenorhabditis elegans individuals during chemotactic response.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble beta-amyloid1-40 induces NMDA-dependent degradation of postsynaptic density-95 at glutamatergic synapses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antioxidant compounds have potent anti-fibrillogenic and fibril-destabilizing effects for alpha-synuclein fibrils in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A specific amyloid-beta protein assembly in the brain impairs memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Ginkgo Evaluation of Memory (GEM) study: design and baseline data of a randomized trial of Ginkgo biloba extract in prevention of dementia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel tricyclic pyrone compound ameliorates cell death associated with intracellular amyloid-beta oligomeric complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polyglutamine proteins at the pathogenic threshold display neuron-specific aggregation in a pan-neuronal Caenorhabditis elegans model

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opposing activities protect against age-onset proteotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ginkgo biloba and donepezil: a comparison in the treatment of Alzheimer's dementia in a randomized placebo-controlled double-blind study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monoclonal antibodies that target pathological assemblies of Abeta

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ginkgolides

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serotonin and octopamine in the nematode Caenorhabditis elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A calcium-channel homologue required for adaptation to dopamine and serotonin in Caenorhabditis elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-activity analyses of beta-amyloid peptides: contributions of the beta 25-35 region to aggregation and neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Odorant-selective genes and neurons mediate olfaction in C. elegans.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neuroprotective properties of the Ginkgo biloba leaf: a review of the possible relationship to platelet-activating factor (PAF).

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genes affecting sensitivity to serotonin in Caenorhabditis elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/17167099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.3448-06.2006

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23 December 2019

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23 December 2019

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23 December 2019

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