Inhibition of C-jun N-terminal kinase improves insulin sensitivity but worsens albuminuria in experimental diabetes (Q46275218)

21 December 2017

title

Inhibition of C-jun N-terminal kinase improves insulin sensitivity but worsens albuminuria in experimental diabetes (English)

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21 December 2017

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21 December 2017

Camillo Ricordi

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21 December 2017

Oliver Lenz

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Ruth D Molano

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Alexandra Jauregui

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21 December 2017

author name string

Adeel Ijaz

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21 December 2017

Thor Tejada

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21 December 2017

Paola Catanuto

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21 December 2017

Xiaomei Xia

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21 December 2017

Sharon J Elliot

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21 December 2017

Maria O Saenz

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21 December 2017

Alessia Fornoni

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21 December 2017

language of work or name

English

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publication date

29 October 2008

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21 December 2017

published in

Kidney International

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21 December 2017

volume

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21 December 2017

issue

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21 December 2017

page(s)

381-388

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21 December 2017

Absolute level and rate of change of albuminuria over 1 year independently predict mortality and cardiovascular events in patients with diabetic nephropathy

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Elevated levels of interleukin-18 and tumor necrosis factor-alpha in serum of patients with type 2 diabetes mellitus: relationship with diabetic nephropathy

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Role of inflammation in diabetic nephropathy

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Insulin resistance and abnormal albumin excretion in non-diabetic first-degree relatives of patients with NIDDM.

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Insulin resistance, hypertension and microalbuminuria in patients with type 2 (non-insulin-dependent) diabetes mellitus

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Insulin Resistance and Microalbuminuria: A Cross-Sectional, Case-Control Study of 158 Patients With Type 2 Diabetes and Different Degrees of Urinary Albumin Excretion

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c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis

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Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide

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The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

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A central role for JNK in obesity and insulin resistance

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Inhibition of c-jun N terminal kinase (JNK) improves functional beta cell mass in human islets and leads to AKT and glycogen synthase kinase-3 (GSK-3) phosphorylation

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Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes

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The human glomerular podocyte is a novel target for insulin action

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Failure to phosphorylate AKT in podocytes from mice with early diabetic nephropathy promotes cell death

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Cross-talk between phosphatidylinositol 3-kinase/AKT and c-jun NH2-terminal kinase mediates survival of isolated human islets

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Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes.

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Diabetes reduces basal retinal insulin receptor signaling: reversal with systemic and local insulin

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Spectrum of renal diseases associated with extreme forms of insulin resistance

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Efficacy and safety of pioglitazone versus metformin in patients with type 2 diabetes mellitus: a double-blind, randomized trial

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Rosiglitazone decreases albuminuria in type 2 diabetic patients

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Thiazolidinediones provide better renoprotection than insulin in an obese, hypertensive type II diabetic rat model

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7 January 2021

Rosiglitazone evaluated for cardiovascular outcomes--an interim analysis

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7 January 2021

Glomerular and tubular induction of the transcription factor c-Jun in human renal disease

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7 January 2021

Severe insulin resistance secondary to insulin antibodies: successful treatment with the immunosuppressant MMF.

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Insulin sensitivity in Type 1 diabetic children and adolescents

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Albumin excretion rate in normal adolescents: relation to insulin resistance and cardiovascular risk factors and comparisons to type 1 diabetes mellitus patients

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JNK-independent activation of c-Jun during neuronal apoptosis induced by multiple DNA-damaging agents

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7 January 2021

Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch

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7 January 2021

Nephrin Is Critical for the Action of Insulin on Human Glomerular Podocytes

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7 January 2021

Identifiers

DOI

10.1038/KI.2008.559

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21 December 2017

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21 December 2017