Blocking the hedgehog pathway inhibits hepatoblastoma growth. (Q46141818)

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20 January 2020

title

Blocking the hedgehog pathway inhibits hepatoblastoma growth (English)

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20 January 2020

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20 January 2020

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20 January 2020

Melanie Eichenmüller

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20 January 2020

Ivonne Gruner

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20 January 2020

Beate Häberle

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20 January 2020

Josef Müller-Höcker

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20 January 2020

Dietrich von Schweinitz

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20 January 2020

language of work or name

English

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publication date

1 February 2009

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20 January 2020

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20 January 2020

volume

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20 January 2020

issue

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20 January 2020

page(s)

482-490

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Primary hepatic tumors of childhood

20 January 2020

cites work

1 reference

Malignant hepatic tumours in children: incidence, clinical features and aetiology

21 January 2018

1 reference

Hepatoblastoma incidence in the United States from 1973 to 1992

21 January 2018

1 reference

SIOPEL trials using preoperative chemotherapy in hepatoblastoma

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Pretreatment prognostic factors and treatment results in children with hepatoblastoma: a report from the German Cooperative Pediatric Liver Tumor Study HB 94.

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Role for hedgehog signaling in hepatic stellate cell activation and viability

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Hedgehog signaling maintains resident hepatic progenitors throughout life

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Tissue repair and stem cell renewal in carcinogenesis

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Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

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Activation of the hedgehog pathway in human hepatocellular carcinomas.

21 January 2018

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Hedgehog signaling in human hepatocellular carcinoma

21 January 2018

1 reference

Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis

21 January 2018

1 reference

p57(KIP2) is not mutated in hepatoblastoma but shows increased transcriptional activity in a comparative analysis of the three imprinted genes p57(KIP2), IGF2, and H19

21 January 2018

1 reference

A new mathematical model for relative quantification in real-time RT-PCR

21 January 2018

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Gene expression analysis of murine cells producing amphotropic mouse leukaemia virus at a cultivation temperature of 32 and 37 degrees C.

21 January 2018

1 reference

Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms

21 January 2018

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Unmasking of epigenetically silenced genes reveals DNA promoter methylation and reduced expression of PTCH in breast cancer

21 January 2018

1 reference

Methylation of PTCH1, the Patched-1 gene, in a panel of primary medulloblastomas

21 January 2018

1 reference

Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2

21 January 2018

1 reference

Transitional liver cell tumors (TLCT) in older children and adolescents: a novel group of aggressive hepatic tumors expressing beta-catenin.

21 January 2018

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Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

21 January 2018

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Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

21 January 2018

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Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis

21 January 2018

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Hedgehog signalling in colorectal tumour cells: induction of apoptosis with cyclopamine treatment

21 January 2018

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Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

21 January 2018

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Inhibition of GLI1 gene activation by Patched1

21 January 2018

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Hepatocellular carcinoma pathogenesis: from genes to environment

21 January 2018

1 reference

Transcriptional silencing of hedgehog-interacting protein by CpG hypermethylation and chromatic structure in human gastrointestinal cancer.

21 January 2018

1 reference

Down-regulation of hedgehog-interacting protein through genetic and epigenetic alterations in human hepatocellular carcinoma.

21 January 2018

1 reference

Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in several human tumors

21 January 2018

1 reference

Characterization of genomic alterations in hepatoblastomas. A role for gains on chromosomes 8q and 20 as predictors of poor outcome

21 January 2018

1 reference

Comparative genomic hybridization reveals population-based genetic alterations in hepatoblastomas

21 January 2018

1 reference

Whole-genome profiling of chromosomal aberrations in hepatoblastoma using high-density single-nucleotide polymorphism genotyping microarrays

21 January 2018

1 reference

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

21 January 2018

1 reference

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

21 January 2018

1 reference

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

21 January 2018

1 reference

Hedgehog signalling in prostate regeneration, neoplasia and metastasis

21 January 2018

1 reference

Hedgehog-mediated mesenchymal–epithelial interactions modulate hepatic response to bile duct ligation

21 January 2018

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Selective down-regulation of glioma-associated oncogene 2 inhibits the proliferation of hepatocellular carcinoma cells

1 reference