BCL2 predicts survival in germinal center B-cell-like diffuse large B-cell lymphoma treated with CHOP-like therapy and rituximab (Q46068969)

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English	BCL2 predicts survival in germinal center B-cell-like diffuse large B-cell lymphoma treated with CHOP-like therapy and rituximab	scientific article

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Europe PubMed Central

PubMed publication ID

21933893

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19 December 2017

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http://europepmc.org/abstract/MED/21933893

title

BCL2 predicts survival in germinal center B-cell-like diffuse large B-cell lymphoma treated with CHOP-like therapy and rituximab (English)

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PubMed publication ID

21933893

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19 December 2017

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http://europepmc.org/abstract/MED/21933893

main subject

B-cell lymphoma

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inferred from title

diffuse large B-cell lymphoma

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author

Elaine Jaffe

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10

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PubMed publication ID

21933893

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19 December 2017

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http://europepmc.org/abstract/MED/21933893

Jan Delabie

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13

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21933893

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Elías Campo

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Elias Campo

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14

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Joseph M Connors

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7

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Joseph M Connors

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PubMed publication ID

21933893

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Randy D Gascoyne

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Randy D Gascoyne

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21933893

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Wing C Chan

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Wing C Chan

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21933893

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James O Armitage

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James O Armitage

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21933893

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Julie M Vose

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Julie M Vose

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Dennis D Weisenburger

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Dennis D Weisenburger

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21933893

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Andreas Rosenwald

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Andreas Rosenwald

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Lisa M Rimsza

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Lisa Rimsza

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Rita M. Braziel

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Rita M Braziel

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Javeed Iqbal

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Javeed Iqbal

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21933893

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Timothy Greiner

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Timothy C Greiner

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21933893

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19 December 2017

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Paul N Meyer

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2

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21933893

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19 December 2017

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Lynette M Smith

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21933893

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19 December 2017

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http://europepmc.org/abstract/MED/21933893

Nathalie A Johnson

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4

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21933893

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19 December 2017

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Louis M Staudt

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8

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PubMed publication ID

21933893

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19 December 2017

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http://europepmc.org/abstract/MED/21933893

German Ott

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12

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21933893

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19 December 2017

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http://europepmc.org/abstract/MED/21933893

James R Cook

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16

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21933893

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19 December 2017

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Raymond R Tubbs

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17

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21933893

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http://europepmc.org/abstract/MED/21933893

language of work or name

English

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publication date

20 September 2011

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21933893

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19 December 2017

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http://europepmc.org/abstract/MED/21933893

published in

Clinical Cancer Research

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Europe PubMed Central

PubMed publication ID

21933893

retrieved

19 December 2017

reference URL

http://europepmc.org/abstract/MED/21933893

volume

17

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PubMed publication ID

21933893

retrieved

19 December 2017

reference URL

http://europepmc.org/abstract/MED/21933893

issue

24

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21933893

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19 December 2017

reference URL

http://europepmc.org/abstract/MED/21933893

page(s)

7785-7795

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21933893

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cites work

Clinical significance of bcl2 and p53 protein expression in diffuse large B-cell lymphoma: a population-based study.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

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12 December 2020

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Gene expression predicts overall survival in paraffin-embedded tissues of diffuse large B-cell lymphoma treated with R-CHOP.

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PubMed

reference URL

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12 December 2020

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Aberrant expression of the neuronal transcription factor FOXP2 in neoplastic plasma cells.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

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12 December 2020

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The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

retrieved

12 December 2020

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inferred from PubMed ID database lookup

Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

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12 December 2020

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Prognostic significance of bcl-2 protein expression in aggressive non-Hodgkin's lymphoma. Groupe d'Etude des Lymphomes de l'Adulte (GELA)

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12 December 2020

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CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

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12 December 2020

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Prognostic significance of Bcl-2 protein expression and Bcl-2 gene rearrangement in diffuse aggressive non-Hodgkin's lymphoma

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21933893

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12 December 2020

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Phase II study of rituximab in combination with chop chemotherapy in patients with previously untreated, aggressive non-Hodgkin's lymphoma

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21933893

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12 December 2020

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Paraffin-based 6-gene model predicts outcome in diffuse large B-cell lymphoma patients treated with R-CHOP.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21933893

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12 December 2020

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Expression of p21 protein predicts clinical outcome in DLBCL patients older than 60 years treated with R-CHOP but not CHOP: a prospective ECOG and Southwest Oncology Group correlative study on E4494.

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PubMed

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12 December 2020

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BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphoma

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21933893

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12 December 2020

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Bcl-2 family proteins: regulators of apoptosis and chemoresistance in hematologic malignancies

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21933893

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-inducible factor-1 {alpha} expression predicts superior survival in patients with diffuse large B-cell lymphoma treated with R-CHOP.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21933893

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12 December 2020

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Akt1 and Akt2 promote peripheral B-cell maturation and survival

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21933893

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12 December 2020

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Prognostic impact of immunohistochemical biomarkers in diffuse large B-cell lymphoma in the rituximab era.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21933893

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12 December 2020

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Follicular dendritic cell-dependent drug resistance of non-Hodgkin lymphoma involves cell adhesion-mediated Bim down-regulation through induction of microRNA-181a

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21933893

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene expression profiling in lymphoma diagnosis and management

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rituximab plus CHOP (R-CHOP) overcomes bcl-2--associated resistance to chemotherapy in elderly patients with diffuse large B-cell lymphoma (DLBCL).

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CHOP-R therapy overcomes the adverse prognostic influence of BCL-2 expression in diffuse large B-cell lymphoma

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21933893

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12 December 2020

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Prognostic significance of immunohistochemical biomarkers in diffuse large B-cell lymphoma: a study from the Lunenburg Lymphoma Biomarker Consortium

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21933893

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12 December 2020

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CLLU1 expression analysis adds prognostic information to risk prediction in chronic lymphocytic leukemia.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 but not FOXP1, is an adverse risk factor in immunochemotherapy-treated non-germinal center diffuse large B-cell lymphomas.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The revised International Prognostic Index (R-IPI) is a better predictor of outcome than the standard IPI for patients with diffuse large B-cell lymphoma treated with R-CHOP

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new immunostain algorithm classifies diffuse large B-cell lymphoma into molecular subtypes with high accuracy

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical methods for predicting cell of origin and survival in patients with diffuse large B-cell lymphoma treated with rituximab

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stromal gene signatures in large-B-cell lymphomas

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21933893

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12 December 2020

based on heuristic

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Prognostic significance of BCL-2 expression and bcl-2 major breakpoint region rearrangement in diffuse large cell non-Hodgkin's lymphoma: a British National Lymphoma Investigation Study

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21933893

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12 December 2020

based on heuristic

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Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RETRACTED: Immunohistochemical prognostic markers in diffuse large B-cell lymphoma: validation of tissue microarray as a prerequisite for broad clinical applications (a study from the Lunenburg Lymphoma Biomarker Consortium)

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene-expression profiling and not immunophenotypic algorithms predicts prognosis in patients with diffuse large B-cell lymphoma treated with immunochemotherapy

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Addition of rituximab to standard chemotherapy improves the survival of both the germinal center B-cell-like and non-germinal center B-cell-like subtypes of diffuse large B-cell lymphoma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BCL2 expression is a prognostic marker for the activated B-cell-like type of diffuse large B-cell lymphoma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical significance of bcl-2-MBR gene rearrangement and protein expression in diffuse large-cell non-Hodgkin's lymphoma: an analysis of 83 cases

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pivotal advance: CEACAM1 is a negative coreceptor for the B cell receptor and promotes CD19-mediated adhesion of B cells in a PI3K-dependent manner

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rituximab (anti-CD20) selectively modifies Bcl-xL and apoptosis protease activating factor-1 (Apaf-1) expression and sensitizes human non-Hodgkin's lymphoma B cell lines to paclitaxel-induced apoptosis.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dose-adjusted EPOCH chemotherapy for untreated large B-cell lymphomas: a pharmacodynamic approach with high efficacy

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements are aggressive neoplasms with clinical and pathologic features distinct from Burkitt lymphoma and diffuse large B-cell lymphoma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic significance of the Bcl-2 negative germinal centre in patients with diffuse large B cell lymphoma treated with R-CHOP.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BCL2 gene aberration as an IPI-independent marker for poor outcome in non-germinal-centre diffuse large B cell lymphoma.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rituximab therapy in malignant lymphoma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Germinal center phenotype and bcl-2 expression combined with the International Prognostic Index improves patient risk stratification in diffuse large B-cell lymphoma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical relevance of BCL2, BCL6, and MYC rearrangements in diffuse large B-cell lymphoma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estimating the impact of rituximab on bcl-2-associated resistance to CHOP in elderly patients with diffuse large B-cell lymphoma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic significance of Bcl-6 protein expression in DLBCL treated with CHOP or R-CHOP: a prospective correlative study

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A predictive model for aggressive non-Hodgkin's lymphoma. The International Non-Hodgkin's Lymphoma Prognostic Factors Project

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21933893

retrieved

12 December 2020

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Identifiers

DOI

10.1158/1078-0432.CCR-11-0267

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21933893

retrieved

19 December 2017

reference URL

http://europepmc.org/abstract/MED/21933893

Fatcat ID

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Fatcat

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24 November 2022

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PMC publication ID

7394278

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PubMed publication ID

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1 reference

stated in

Europe PubMed Central

PubMed publication ID

21933893

retrieved

19 December 2017

reference URL

http://europepmc.org/abstract/MED/21933893

 

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