Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics (Q46055776)

19 December 2017

review article

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title

Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics (English)

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19 December 2017

author name string

Wacher VJ

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19 December 2017

Silverman JA

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19 December 2017

Zhang Y

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19 December 2017

Benet LZ

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19 December 2017

language of work or name

English

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publication date

1 November 1998

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19 December 2017

Journal of Pharmaceutical Sciences

published in

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19 December 2017

volume

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19 December 2017

issue

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19 December 2017

page(s)

1322-1330

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19 December 2017

Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man

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Fetus-specific expression of a form of cytochrome P-450 in human livers

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Expression of xenobiotic-metabolizing cytochrome P450 forms in human adult and fetal liver

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Identification of an inducible form of cytochrome P-450 in human liver

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Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver

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Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s

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Significance of cytochrome P-450 (P-450 HFLa) of human fetal livers in the steroid and drug oxidations

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Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily

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Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes

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The fetal specific gene CYP3A7 is inducible by rifampicin in adult human hepatocytes in primary culture.

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CYP3A gene expression in human gut epithelium

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Characterisation of CYP3A gene subfamily expression in human gastrointestinal tissues

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Expression of CYP3A4, CYP3A5 and CYP3A7 in human duodenal tissue

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Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression

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Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine*

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Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1alpha,25-dihydroxyvitamin D3.

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First-pass metabolism of midazolam by the human intestine.

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Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism

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Drug interactions and interindividual variability of ciclosporin metabolism in the small intestine

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Selective expression of CYP3A5 and not CYP3A4 in human blood

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Detection of CYP3A5 allelic variant: a candidate for the polymorphic expression of the protein?

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Expression of cytochrome P450 3A in amphibian, rat, and human kidney

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Detection of human lung cytochromes P450 that are immunochemically related to cytochrome P450IIE1 and cytochrome P450IIIA

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Expression and localization of CYP3A4 and CYP3A5 in human lung

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Cytochrome P450 CYP3A5 in the human anterior pituitary gland

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Classical and novel forms of multidrug resistance and the physiological functions of P-glycoproteins in mammals

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The immunocytochemical localisation and distribution of cytochrome P-450 in normal human hepatic and extrahepatic tissues with a monoclonal antibody to human cytochrome P-450

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Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation

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P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans

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Differentiation of absorption and first-pass gut and hepatic metabolism in humans: Studies with cyclosporine*

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The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine*

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Disposition of intravenous and oral cyclosporine after administration with grapefruit juice

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The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers

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First-pass metabolism of cyclosporin by the gut

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Relevance of p-glycoprotein for the enteral absorption of cyclosporin A: in vitro-in vivo correlation

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Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

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Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir.

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Saquinavir pharmacokinetics alone and in combination with ritonavir in HIV-infected patients

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

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Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

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Epithelial secretion of vinblastine by human intestinal adenocarcinoma cell (HCT-8 and T84) layers expressing P-glycoprotein

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Vinyl Sulfones as Mechanism-Based Cysteine Protease Inhibitors

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Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

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Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833

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7 January 2021

Identifiers

DOI

10.1021/JS980082D

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19 December 2017

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19 December 2017