Model-driven engineering of RNA devices to quantitatively program gene expression (Q46041667)

18 December 2017

title

Model-driven engineering of RNA devices to quantitatively program gene expression (English)

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18 December 2017

Jay D Keasling

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18 December 2017

author name string

James M Carothers

series ordinal

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18 December 2017

Jonathan A Goler

series ordinal

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18 December 2017

Darmawi Juminaga

series ordinal

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18 December 2017

language of work or name

English

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publication date

1 December 2011

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18 December 2017

published in

Science

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18 December 2017

volume

334

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18 December 2017

issue

6063

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18 December 2017

page(s)

1716-1719

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18 December 2017

https://api.crossref.org/works/10.1126%2FSCIENCE.1212209

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Manufacturing molecules through metabolic engineering

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Functional information and the emergence of biocomplexity

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Synthetic biology: applications come of age

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Chemical synthesis using synthetic biology

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Ribozymes and Riboswitches: Modulation of RNA Function by Small Molecules

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1 reference

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Synthetic biology with RNA motifs

21 January 2018

1 reference

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Cell biology. The case for RNA.

21 January 2018

1 reference

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Design principles for ligand-sensing, conformation-switching ribozymes

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.1212209

Engineering static and dynamic control of synthetic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1212209

RNA-based computation in live cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1212209

A switch in time: detailing the life of a riboswitch

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1212209

The bacterial enzyme RppH triggers messenger RNA degradation by 5' pyrophosphate removal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1212209

Measuring the activity of BioBrick promoters using an in vivo reference standard

21 January 2018

1 reference

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A modular and extensible RNA-based gene-regulatory platform for engineering cellular function

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1212209

Tertiary contacts distant from the active site prime a ribozyme for catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1212209

Engineering high-speed allosteric hammerhead ribozymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1212209

Selecting RNA aptamers for synthetic biology: investigating magnesium dependence and predicting binding affinity

21 January 2018

1 reference

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RNA folding during transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1212209

Automated design of synthetic ribosome binding sites to control protein expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1212209

The jerky and knotty dynamics of RNA.

21 January 2018

1 reference

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4-aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV

21 January 2018

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Development of a combined biological and chemical process for production of industrial aromatics from renewable resources

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Combinatorial engineering of intergenic regions in operons tunes expression of multiple genes

21 January 2018

1 reference

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Generation of a bacterium with a 21 amino acid genetic code

21 January 2018

1 reference

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Beyond energy minimization: approaches to the kinetic folding of RNA

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.1212209

Widespread occurrence of self-cleaving ribozymes

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.1212209

Programming cells by multiplex genome engineering and accelerated evolution

21 January 2018

1 reference

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Survey of sampling-based methods for uncertainty and sensitivity analysis

21 January 2018

1 reference

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In vitro evolution suggests multiple origins for the hammerhead ribozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1212209

Effect of gene location, mRNA secondary structures, and RNase sites on expression of two genes in an engineered operon

21 January 2018

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A propionate-inducible expression system for enteric bacteria

21 January 2018

1 reference

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L-tyrosine production by deregulated strains of Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1212209

The effect of transcription and translation initiation frequencies on the stochastic fluctuations in prokaryotic gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1212209

Bacteriophage T7 RNA polymerase travels far ahead of ribosomes in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1212209

Late events of translation initiation in bacteria: a kinetic analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1212209

Translational standby sites: how ribosomes may deal with the rapid folding kinetics of mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1212209

Folding of the natural hammerhead ribozyme is enhanced by interaction of auxiliary elements.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1212209

Sequence elements outside the hammerhead ribozyme catalytic core enable intracellular activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1212209

Global RNA half-life analysis in Escherichia coli reveals positional patterns of transcript degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1212209

Initiation of RNA decay in Escherichia coli by 5' pyrophosphate removal

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1212209

Surviving heat shock: control strategies for robustness and performance

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1212209

Kinetic characterization of intramolecular and intermolecular hammerhead RNAs with stem II deletions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1212209

Leakage and slow allostery limit performance of single drug-sensing aptazyme molecules based on the hammerhead ribozyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1212209

Vienna RNA secondary structure server

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1212209

21 January 2018

Identifiers

DOI

10.1126/SCIENCE.1212209

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18 December 2017

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18 December 2017